|
Multiple Myeloma
|
0.330 |
PosttranslationalModification
|
disease |
BEFREE |
Among primary tumours, methylation of BNIP3 was detected in five of 34 (15%) acute lymphocytic leukaemias, six of 35 (17%) acute myelogenous leukaemias and three of 14 (21%) multiple myelomas.
|
15756280 |
2005 |
|
Multiple Myeloma
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
Interestingly, methylation of SPARC and BNIP3 was statistically significantly associated with a poor overall survival of MM patients (P = 0.003 and P = 0.017, respectively).
|
18172295 |
2008 |
|
Multiple Myeloma
|
0.330 |
AlteredExpression
|
disease |
BEFREE |
Serum deprivation markedly blocked survival at earlier time points in CS1 knockdown compared with control MM cells, associated with earlier activation of caspases, poly(ADP-ribose) polymerase, and proapoptotic proteins BNIP3 and BIK.
|
19196658 |
2009 |
|
Malignant neoplasm of prostate
|
0.320 |
PosttranslationalModification
|
disease |
BEFREE |
Hypomethylation of BNIP3 (31.25 ± 16.19 vs. 45.70 ± 2.42 %, p < 0.0001), hypermethylation of Ec-SOD (71.4 ± 6.75 vs. 10.0 ± 3.78 %, p < 0.0001) and RASSF1 (76.25 ± 12.53 vs. 30.0 ± 8.82 %, p = 0.0077) was observed in prostate cancer.
|
23979608 |
2013 |
|
Malignant neoplasm of prostate
|
0.320 |
Biomarker
|
disease |
BEFREE |
This study investigated the role of BNIP3 in prostate cancer.
|
18163427 |
2008 |
|
Malignant neoplasm of stomach
|
0.310 |
PosttranslationalModification
|
disease |
BEFREE |
Aberrant methylation of BNIP3 was also detected in 66% of primary colorectal and 49% of primary gastric cancers, but not in normal tissue samples collected from areas adjacent to the tumors.
|
15709167 |
2005 |
|
Prostatic Neoplasms
|
0.310 |
AlteredExpression
|
group |
BEFREE |
These findings suggest that BNIP3 is directly regulated by hypoxia but that there may be a hormonal independent mechanism coordinating the expression of BNIP3 in prostate tumors.
|
18163427 |
2008 |
|
Heart failure
|
0.230 |
AlteredExpression
|
disease |
BEFREE |
In the present study, we reviewed the changes in BNIP3 protein expression levels during inflammatory response and postulated its role in inflammation-mediated HF.
|
27112557 |
2016 |
|
Heart failure
|
0.230 |
Biomarker
|
disease |
BEFREE |
The cell death activity of a subclass of BH3-only members (BNIP3 and BNIP3L) is linked to cardiomyocyte loss during heart failure.
|
19641503 |
2008 |
|
Heart failure
|
0.230 |
Biomarker
|
disease |
BEFREE |
The FOXO3a (forkhead box O3a)-BNIP3 (B-cell lymphoma 2/adenovirus E1B 19kDa interacting protein 3) pathway modulates mitochondrial dynamics and function and contributes to myocardial remodeling in rodent models of heart failure.
|
30744415 |
2019 |
|
Congestive heart failure
|
0.230 |
Biomarker
|
disease |
BEFREE |
The FOXO3a (forkhead box O3a)-BNIP3 (B-cell lymphoma 2/adenovirus E1B 19kDa interacting protein 3) pathway modulates mitochondrial dynamics and function and contributes to myocardial remodeling in rodent models of heart failure.
|
30744415 |
2019 |
|
Congestive heart failure
|
0.230 |
Biomarker
|
disease |
BEFREE |
The cell death activity of a subclass of BH3-only members (BNIP3 and BNIP3L) is linked to cardiomyocyte loss during heart failure.
|
19641503 |
2008 |
|
Congestive heart failure
|
0.230 |
AlteredExpression
|
disease |
BEFREE |
In the present study, we reviewed the changes in BNIP3 protein expression levels during inflammatory response and postulated its role in inflammation-mediated HF.
|
27112557 |
2016 |
|
Chronic Obstructive Airway Disease
|
0.210 |
Biomarker
|
disease |
BEFREE |
Treatment of COPD myotubes with ascorbic acid decreased ROS concentration (p < 0.001), ROS-induced protein carbonylation (p = 0.019), the LC3 2/LC3 1 ratio (p = 0.037), the expression of SQSTM1 (p < 0.001) and BNIP3 (p < 0.001), and increased the COPD myotube diameter (p < 0.001).
|
29943813 |
2018 |
|
Myocardial Infarction
|
0.210 |
Biomarker
|
disease |
BEFREE |
Thus, the purpose of this study was to test the hypothesis that miR-105 participates in the regulation of RIP3/p-MLKL- and BNIP3-dependent necroptosis/apoptosis in H9c2 cells and MI rat hearts.
|
30743213 |
2019 |
|
Retinal Detachment
|
0.210 |
Biomarker
|
disease |
BEFREE |
Our previous study demonstrated the protective effect on detached retina by BNIP3-mediated autophagy.
|
31072291 |
2019 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Collectively, our results identified Hippo-Yap as the tumor promoter in hepatocellular carcinoma that mediated via activation of cofilin/F-actin/lamellipodium axis by limiting JNK-Bnip3-SERCA-CaMKII pathways, with potential application to HCC therapy involving cancer metastasis.
|
28869833 |
2018 |
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
SDHB PCC are associated with a high risk of malignancy, and expression of (proapototic) BNIP3 was significantly lower in SDHB than VHL PCC.
|
16954163 |
2006 |
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Hypoxia-inducible factor 1 (HIF-1) plays a key role in the reprogramming of cancer metabolism by activating transcription of genes encoding glucose transporters and glycolytic enzymes, which take up glucose and convert it to lactate; pyruvate dehydrogenase kinase 1, which shunts pyruvate away from the mitochondria; and BNIP3, which triggers selective mitochondrial autophagy.
|
19942427 |
2010 |
|
Malignant Neoplasms
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
Two esophageal squamous cancer cell lines, CAES17 and KYSE140, were selected on the basis of the expression and methylation status of BNIP3 to investigate the features of BNIP3 under hypoxia.
|
28859361 |
2017 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
p53/BNIP3-dependent mitophagy limits glycolytic shift in radioresistant cancer.
|
30664690 |
2019 |
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Therefore, through different cellular process altered expression of BNIP3 may differently contribute to cancer development and progression.
|
25950386 |
2015 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our findings identify the critical role of BNIP3 in blockade of autophagosome-lysosome fusion mediated by BBM, and suggest that BBM could potentially be further developed as a novel autophagy inhibitor, which could enhance the effect of chemotherapy to cancer.
|
29445175 |
2018 |
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In contrast to the cancer cells, epithelial cells in normal gastric mucosa showed no or weak expression of BNIP3.
|
18092960 |
2007 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The mean score of BNIP3 in cancer was 1.8±0.2 and it was 3.7±0.5 in adjacent colorectum (<i>p</i><0.05).
|
28607593 |
2017 |