|
Adult Pilocytic Astrocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Detection of the KIAA1549-BRAF fusion gene in cells forming microvascular proliferations in pilocytic astrocytoma.
|
31329636 |
2019 |
|
Adult Pilocytic Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Activation of the MAP Kinase (MAPK) pathway caused by the BRAFV600E mutation or the KIAA1549-BRAF fusion has been reported in pediatric GG and PA, respectively.
|
25524464 |
2014 |
|
Adult Pilocytic Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In addition, our study confirmed previously reported BRAF and RAF1 fusion variants in 72% (90/125) of PA. Mutations in BRAF (8/125), KRAS (2/125) and NF1 (4/125) and the rare RAF1 gene fusions (2/125) were mutually exclusive with BRAF rearrangements, with the exception of two cases in our series that concomitantly harbored more than one hit in the MAPK pathway.
|
21424530 |
2011 |
|
Adult Pilocytic Astrocytoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The review of imaging features indicated that cyst formation is associated with the existence of KIAA1549-BRAF fusion in PA and GG and the lack of BRAF mutation in GG.
|
31147232 |
2019 |
|
Adult Pilocytic Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
BRAF mutations are most frequently detected in certain subtypes of low-grade glioma, such as pilocytic astrocytoma (PA), pleomorphic xanthoastrocytoma (PXA), ganglioglioma (GG) and dysembryoplastic neuroepithelial tumor (DNT).
|
27792249 |
2017 |
|
Adult Pilocytic Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Aneuploid genomes were identified in 45% of adult compared with 17% of pediatric PA. Gains were non-random, favoring chromosomes 5, 7, 6 and 11 in order of frequency, and preferentially affecting non-cerebellar PA and tumors with BRAF V600E mutations and not with KIAA1549-BRAF fusions or FGFR1 mutations.
|
26378811 |
2015 |
|
Adult Pilocytic Astrocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Given that the BRAF sequence deleted is identical to that seen in other fusion events in PA, it most likely acts as tumor driver by activation of the MAPK pathway.
|
29141672 |
2017 |
|
Adult Pilocytic Astrocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, combined molecular analysis of BRAF and IDH1 is a sensitive and highly specific approach to separate pilocytic astrocytoma from diffuse astrocytoma.
|
19543740 |
2009 |
|
Adult Pilocytic Astrocytoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The mean score of BRAF expression in the PA group was significantly higher than that in the GS group (p = 0.019).
|
29168690 |
2018 |
|
Adult Pilocytic Astrocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Correction: A new GTF2I-BRAF fusion mediating MAPK pathway activation in pilocytic astrocytoma.
|
28880959 |
2019 |
|
Adult Pilocytic Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Pilocytic astrocytoma (PA), the most common childhood brain tumor, is a low-grade glioma with a single driver BRAF rearrangement.
|
31427603 |
2019 |
|
Adult Pilocytic Astrocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Induction of senescence by BRAF may help explain the low-grade pathobiology of pilocytic astrocytoma, whereas worse clinical outcomes associated with tumors lacking p16(INK4a) expression could reflect failure to induce senescence or an escape from oncogene-induced senescence.
|
21636552 |
2011 |
|
Adult Pilocytic Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our results further emphasize the importance of BRAF alterations in PA and the need to characterize them in a given tumor as this can affect therapeutic strategies and their potential use as tumor marker in molecular diagnostics.
|
30575814 |
2019 |
|
Adult Pilocytic Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Activating point mutations of BRAF, such as BRAF (V600E), also lead to pilocytic astrocytoma.
|
23439714 |
2013 |
|
Adult Pilocytic Astrocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Genetic mechanisms such as activation of MAPK, BRAF gene deregulation and neurofibromatosis type 1 (NF1) syndrome have been associated with PA development.
|
30570705 |
2019 |
|
Adult Pilocytic Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
BRAF-V600E mutations are most commonly found in pleomorphic xanthoastrocytoma, ganglioglioma, epithelioid glioblastoma, and gliomas diagnosed at a younger age; BRAF-KIAA1549 fusion is the most common BRAF alteration in pilocytic astrocytoma.
|
30265855 |
2018 |
|
Adult Pilocytic Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Overall 36% of APAs harbored BRAF and/or FGFR genetic alterations.
|
27608415 |
2017 |
|
Adult Pilocytic Astrocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The KIAA1549:BRAF fusion gene is considered a driver genetic event in pilocytic astrocytoma.
|
25382612 |
2015 |
|
Adult Pilocytic Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
For the first time, we report concomitant presence of a somatic BRAF(V600E) mutation in an NF1 patient indicating that more than one Ras/ERK pathway component can be affected in PA.
|
21190184 |
2011 |
|
Adult Pilocytic Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Although oncogenic rearrangements of the BRAF gene have recently been described in PAs, it is not clear whether such alterations have an impact on outcome.
|
20044755 |
2010 |
|
Adult Pilocytic Astrocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Frequent gains at chromosome 7q34 involving BRAF in pilocytic astrocytoma.
|
18716556 |
2008 |
|
Adult Pilocytic Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Chromosome band 7q34 deletions, which resulted in a FAM131B-BRAF fusion, were identified in one pilocytic astrocytoma (PA) and one dysembryoplastic neuroepithelial tumor (DNT).
|
24767714 |
2014 |
|
Adult Pilocytic Astrocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
BRAF fusion involving the KIAA1549 gene is a hallmark of pilocytic astrocytoma, but it has also been recorded in rare cases of gangliogliomas, 1p/19q co-deleted oligodendroglial tumors, and it is also a common feature of disseminated oligodendroglial-like leptomeningeal neoplasm.
|
29802359 |
2018 |
|
Adult Pilocytic Astrocytoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The unique predilection of these tumors to form within the optic pathway and brainstem (NF1-PA) and cerebellum (sporadic PA) raises the possibility that gliomagenesis requires more than biallelic inactivation of the NF1 tumor suppressor gene or expression of the KIAA1549:BRAF transcript.
|
23624918 |
2014 |
|
Adult Pilocytic Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Adult with cerebellar anaplastic pilocytic astrocytoma associated with BRAF V600E mutation and p16 loss.
|
23196000 |
2013 |