|
Adult Pilocytic Astrocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Frequent gains at chromosome 7q34 involving BRAF in pilocytic astrocytoma.
|
18716556 |
2008 |
|
Adult Pilocytic Astrocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, combined molecular analysis of BRAF and IDH1 is a sensitive and highly specific approach to separate pilocytic astrocytoma from diffuse astrocytoma.
|
19543740 |
2009 |
|
Adult Pilocytic Astrocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Oncogenic RAF1 rearrangement and a novel BRAF mutation as alternatives to KIAA1549:BRAF fusion in activating the MAPK pathway in pilocytic astrocytoma.
|
19363522 |
2009 |
|
Adult Pilocytic Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Alterations of BRAF and HIPK2 loci predominate in sporadic pilocytic astrocytoma.
|
19794125 |
2009 |
|
Adult Pilocytic Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Although oncogenic rearrangements of the BRAF gene have recently been described in PAs, it is not clear whether such alterations have an impact on outcome.
|
20044755 |
2010 |
|
Adult Pilocytic Astrocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The latest discovery involving the tandem duplication and fusion BRAF-KIAA1549 on chromosome 7q34 in pilocytic astrocytoma has drawn attention to the MAPK-ERK pathway and its potential chemotherapeutic manipulation.
|
20919607 |
2010 |
|
Adult Pilocytic Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In addition, our study confirmed previously reported BRAF and RAF1 fusion variants in 72% (90/125) of PA. Mutations in BRAF (8/125), KRAS (2/125) and NF1 (4/125) and the rare RAF1 gene fusions (2/125) were mutually exclusive with BRAF rearrangements, with the exception of two cases in our series that concomitantly harbored more than one hit in the MAPK pathway.
|
21424530 |
2011 |
|
Adult Pilocytic Astrocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Induction of senescence by BRAF may help explain the low-grade pathobiology of pilocytic astrocytoma, whereas worse clinical outcomes associated with tumors lacking p16(INK4a) expression could reflect failure to induce senescence or an escape from oncogene-induced senescence.
|
21636552 |
2011 |
|
Adult Pilocytic Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
For the first time, we report concomitant presence of a somatic BRAF(V600E) mutation in an NF1 patient indicating that more than one Ras/ERK pathway component can be affected in PA.
|
21190184 |
2011 |
|
Adult Pilocytic Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The frequency of BRAF-KIAA1549 fusion transcripts is significantly lower in adult patients with pilocytic astrocytoma, weakening the sensitivity of this specific diagnostic marker in that age group.
|
21696415 |
2011 |
|
Adult Pilocytic Astrocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our in vivo model for PA shows that the activated BRAF kinase domain is sufficient to induce PA and highlights its role as a potential therapeutic target.
|
21403401 |
2011 |
|
Adult Pilocytic Astrocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The emergence of genomic arrays, including comparative genomic hybridization and SNP arrays, have helped in the discovery of novel critically important genes and novel genomic biomarkers involved in PCNST oncogenesis (e.g., BRAF duplication in pilocytic astrocytoma).
|
22468817 |
2012 |
|
Adult Pilocytic Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Activating point mutations of BRAF, such as BRAF (V600E), also lead to pilocytic astrocytoma.
|
23439714 |
2013 |
|
Adult Pilocytic Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Adult with cerebellar anaplastic pilocytic astrocytoma associated with BRAF V600E mutation and p16 loss.
|
23196000 |
2013 |
|
Adult Pilocytic Astrocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our study supports the notion that BRAF duplication is more typical of posterior fossa pilocytic astrocytoma and that molecular alterations other than KIAA1549 fusion may underlie MAPK pathway activation in pilocytic astrocytoma of the optic nerve.
|
23702730 |
2013 |
|
Adult Pilocytic Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Activation of the MAP Kinase (MAPK) pathway caused by the BRAFV600E mutation or the KIAA1549-BRAF fusion has been reported in pediatric GG and PA, respectively.
|
25524464 |
2014 |
|
Adult Pilocytic Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Chromosome band 7q34 deletions, which resulted in a FAM131B-BRAF fusion, were identified in one pilocytic astrocytoma (PA) and one dysembryoplastic neuroepithelial tumor (DNT).
|
24767714 |
2014 |
|
Adult Pilocytic Astrocytoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The unique predilection of these tumors to form within the optic pathway and brainstem (NF1-PA) and cerebellum (sporadic PA) raises the possibility that gliomagenesis requires more than biallelic inactivation of the NF1 tumor suppressor gene or expression of the KIAA1549:BRAF transcript.
|
23624918 |
2014 |
|
Adult Pilocytic Astrocytoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Nevertheless, the most important causative factors seem to be NF1 gene inactivation, in cases related to neurofibromatosis type 1, and BRAF gene overexpression in sporadic PAs, both resulting in MAPK/Erk pathway upregulation.
|
24554201 |
2014 |
|
Adult Pilocytic Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Aneuploid genomes were identified in 45% of adult compared with 17% of pediatric PA. Gains were non-random, favoring chromosomes 5, 7, 6 and 11 in order of frequency, and preferentially affecting non-cerebellar PA and tumors with BRAF V600E mutations and not with KIAA1549-BRAF fusions or FGFR1 mutations.
|
26378811 |
2015 |
|
Adult Pilocytic Astrocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The KIAA1549:BRAF fusion gene is considered a driver genetic event in pilocytic astrocytoma.
|
25382612 |
2015 |
|
Adult Pilocytic Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In case 3, deletions involving BRAF and FAM131B were observed in both a primary and a recurrent PA. RNA-based sequence analysis of cases 2 and 3 confirmed a fusion between FAM131B exon 2 and BRAF exon 9.
|
25040262 |
2015 |
|
Adult Pilocytic Astrocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In summary, we confirmed the high frequency of KIAA1549:BRAF fusion in PAs and its association with a better outcome.
|
26083571 |
2015 |
|
Adult Pilocytic Astrocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The molecular data on PA support a key role for the BRAF oncogene in the pathogenesis of these tumors, with the KIAA1549-BRAF fusion being the most common alteration identified in sporadic cases, particularly those occurring in the posterior fossa.
|
25976257 |
2015 |
|
Adult Pilocytic Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In our study we evaluated 51 PAs for BRAF duplication and BRAF V600E point mutation.
|
25066317 |
2016 |