Adult Pilocytic Astrocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Detection of the KIAA1549-BRAF fusion gene in cells forming microvascular proliferations in pilocytic astrocytoma.
|
31329636 |
2019 |
Adult Pilocytic Astrocytoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The review of imaging features indicated that cyst formation is associated with the existence of KIAA1549-BRAF fusion in PA and GG and the lack of BRAF mutation in GG.
|
31147232 |
2019 |
Adult Pilocytic Astrocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Correction: A new GTF2I-BRAF fusion mediating MAPK pathway activation in pilocytic astrocytoma.
|
28880959 |
2019 |
Adult Pilocytic Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Pilocytic astrocytoma (PA), the most common childhood brain tumor, is a low-grade glioma with a single driver BRAF rearrangement.
|
31427603 |
2019 |
Adult Pilocytic Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our results further emphasize the importance of BRAF alterations in PA and the need to characterize them in a given tumor as this can affect therapeutic strategies and their potential use as tumor marker in molecular diagnostics.
|
30575814 |
2019 |
Adult Pilocytic Astrocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Genetic mechanisms such as activation of MAPK, BRAF gene deregulation and neurofibromatosis type 1 (NF1) syndrome have been associated with PA development.
|
30570705 |
2019 |
Adult Pilocytic Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
KIAA1549-BRAF is the most frequently identified genetic mutation in sporadic pilocytic astrocytoma (PA), creating a fusion BRAF (f-BRAF) protein with increased BRAF activity.
|
30504064 |
2019 |
Adult Pilocytic Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
More recently, cases of PA with gangliocytic differentiation (PA-GD) have been described, and these cases are thus far restricted to those with the KIAA1549-BRAF fusion.
|
31147230 |
2019 |
Adult Pilocytic Astrocytoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The mean score of BRAF expression in the PA group was significantly higher than that in the GS group (p = 0.019).
|
29168690 |
2018 |
Adult Pilocytic Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
BRAF-V600E mutations are most commonly found in pleomorphic xanthoastrocytoma, ganglioglioma, epithelioid glioblastoma, and gliomas diagnosed at a younger age; BRAF-KIAA1549 fusion is the most common BRAF alteration in pilocytic astrocytoma.
|
30265855 |
2018 |
Adult Pilocytic Astrocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
BRAF fusion involving the KIAA1549 gene is a hallmark of pilocytic astrocytoma, but it has also been recorded in rare cases of gangliogliomas, 1p/19q co-deleted oligodendroglial tumors, and it is also a common feature of disseminated oligodendroglial-like leptomeningeal neoplasm.
|
29802359 |
2018 |
Adult Pilocytic Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
However, KIAA1549-BRAF fusion gene was identified by fluorescence in situ hybridization (FISH), supporting for the diagnosis of PA.
|
29768357 |
2018 |
Adult Pilocytic Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These tumors expressed GFAP (5/6), OLIG2 (2/3), and S100 (1/1), and the pilocytic astrocytoma was negative for BRAF (V600E) mutant protein.
|
30074494 |
2018 |
Adult Pilocytic Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
BRAF mutations are most frequently detected in certain subtypes of low-grade glioma, such as pilocytic astrocytoma (PA), pleomorphic xanthoastrocytoma (PXA), ganglioglioma (GG) and dysembryoplastic neuroepithelial tumor (DNT).
|
27792249 |
2017 |
Adult Pilocytic Astrocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Given that the BRAF sequence deleted is identical to that seen in other fusion events in PA, it most likely acts as tumor driver by activation of the MAPK pathway.
|
29141672 |
2017 |
Adult Pilocytic Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Overall 36% of APAs harbored BRAF and/or FGFR genetic alterations.
|
27608415 |
2017 |
Adult Pilocytic Astrocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
DNA methylation array and KIAA1549:BRAF fusion analysis confirmed pilocytic astrocytoma identity of DKFZ-BT66 cells after establishment.
|
28002790 |
2017 |
Adult Pilocytic Astrocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, 1p19q co-deletion and KIAA1549:BRAF fusion were, respectively, restricted to Oligodendroglioma and Pilocytic Astrocytoma.
|
26957305 |
2017 |
Adult Pilocytic Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Using a combined analysis of RNA sequencing and copy number variation data we identified a new BRAF fusion involving the 5' gene fusion partner GTF2I (7q11.23), not previously described in PA.
|
28448514 |
2017 |
Adult Pilocytic Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In our study we evaluated 51 PAs for BRAF duplication and BRAF V600E point mutation.
|
25066317 |
2016 |
Adult Pilocytic Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Aneuploid genomes were identified in 45% of adult compared with 17% of pediatric PA. Gains were non-random, favoring chromosomes 5, 7, 6 and 11 in order of frequency, and preferentially affecting non-cerebellar PA and tumors with BRAF V600E mutations and not with KIAA1549-BRAF fusions or FGFR1 mutations.
|
26378811 |
2015 |
Adult Pilocytic Astrocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The KIAA1549:BRAF fusion gene is considered a driver genetic event in pilocytic astrocytoma.
|
25382612 |
2015 |
Adult Pilocytic Astrocytoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In case 3, deletions involving BRAF and FAM131B were observed in both a primary and a recurrent PA. RNA-based sequence analysis of cases 2 and 3 confirmed a fusion between FAM131B exon 2 and BRAF exon 9.
|
25040262 |
2015 |
Adult Pilocytic Astrocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In summary, we confirmed the high frequency of KIAA1549:BRAF fusion in PAs and its association with a better outcome.
|
26083571 |
2015 |
Adult Pilocytic Astrocytoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The molecular data on PA support a key role for the BRAF oncogene in the pathogenesis of these tumors, with the KIAA1549-BRAF fusion being the most common alteration identified in sporadic cases, particularly those occurring in the posterior fossa.
|
25976257 |
2015 |