Lupus Vulgaris
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Up-regulated expression of Ro52/tripartite motif-containing protein 21 (TRIM21), Ro60/TROVE domain family, member 2 (TROVE2) and lupus LA protein/Sjögren's syndrome antigen B (La/SSB) autoantigens has been described in the salivary gland epithelial cells (SGEC) of patients with Sjögren's syndrome (SS).
|
25098814 |
2014 |
Lupus Vulgaris
|
0.100 |
Biomarker
|
disease |
BEFREE |
These data demonstrate that anti-Ro(SS-A)/La(SS-B) positive Sjogren's/lupus overlap patients and neonatal lupus syndrome mothers are immunogenetically closely related to each other and appear to be more closely related to both primary Sjogren's syndrome and subacute lupus erythematosus, than to classical systemic lupus erythematosus.
|
2584740 |
1989 |
Lupus Vulgaris
|
0.100 |
Biomarker
|
disease |
BEFREE |
The results of this study indicate that the antigenic determinants on Ro52 are different for autoantibodies produced by lupus patients compared with those of SS patients.
|
7693382 |
1993 |
Lupus Vulgaris
|
0.100 |
Biomarker
|
disease |
BEFREE |
Men with lupus had less anti-SSA (21.1 vs 48.1%) and anti-Ro52 (10.5 vs 44.3%) antibodies when compared to women and none of the male patients had anti-SSB antibodies.
|
29265023 |
2017 |
Lupus Vulgaris
|
0.100 |
Biomarker
|
disease |
BEFREE |
Neonatal lupus erythematosus (NLE) is a distinct subset of lupus characterized by cutaneous findings (50%), cardiac conduction defects (50%), and autoantibodies to Ro (SS-A) antigen.
|
1444503 |
1992 |
Lupus Vulgaris
|
0.100 |
Biomarker
|
disease |
BEFREE |
Loss of the lupus autoantigen Ro52/Trim21 induces tissue inflammation and systemic autoimmunity by disregulating the IL-23-Th17 pathway.
|
19635858 |
2009 |
Lupus Vulgaris
|
0.100 |
Biomarker
|
disease |
BEFREE |
Patients with isolated anti-Ro52 had a wider variety of diseases associated, but among auto-immune diseases they were more prone to inflammatory myositis (OR 10.5 [1.4-81.7], <i>p</i> = 0.02) and inflammatory rheumatism (OR 4.6 [1.6-13.8], <i>p</i> = 0.006) in contrast to systemic lupus (OR 0.2 [0.1-0.3], <i>p</i> < 10<sup>-4</sup>) or primary Sjögren's syndrome (OR 0.1 [0.06-0.2], <i>p</i> < 10<sup>-4</sup>).
|
30915082 |
2019 |
Lupus Vulgaris
|
0.100 |
Biomarker
|
disease |
BEFREE |
Genetic knock out of 60kD Ro (or SSA), a common lupus autoantigen, induces lupus.
|
14698275 |
2004 |
Lupus Vulgaris
|
0.100 |
Biomarker
|
disease |
BEFREE |
Autoantibodies to Ro52 are present in patients with lupus and Sjögren's syndrome, but it is not known if these autoantibodies affect the function of Ro52.
|
21862588 |
2011 |
Lupus Vulgaris
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Of the two autoantibodies studied, anti-Ro/anti-SSA levels in borderline lupus patients appeared as an important parameter for monitoring/diagnosis of lupus patients.
|
23832290 |
2013 |
Lupus Erythematosus, Discoid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although this remains among the most attractive of hypotheses for the explanation of Ro/SS-A antibody-associated forms of LESSD such as SCLE and neonatal LE, it does not address the pathogenesis of other forms of LESSD such as DLE, which are not associated with high-level Ro/SS-A antibody production or other known autoantibody specificities (low-level Ro/SS-A autoantibody production has been noted recently in DLE patients (155)).
|
8628749 |
1996 |
Lupus Erythematosus, Discoid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Autoantibodies to Ro52 are present in patients with lupus and Sjögren's syndrome, but it is not known if these autoantibodies affect the function of Ro52.
|
21862588 |
2011 |
Lupus Erythematosus, Discoid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Men with lupus had less anti-SSA (21.1 vs 48.1%) and anti-Ro52 (10.5 vs 44.3%) antibodies when compared to women and none of the male patients had anti-SSB antibodies.
|
29265023 |
2017 |
Lupus Erythematosus, Discoid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Patients with isolated anti-Ro52 had a wider variety of diseases associated, but among auto-immune diseases they were more prone to inflammatory myositis (OR 10.5 [1.4-81.7], <i>p</i> = 0.02) and inflammatory rheumatism (OR 4.6 [1.6-13.8], <i>p</i> = 0.006) in contrast to systemic lupus (OR 0.2 [0.1-0.3], <i>p</i> < 10<sup>-4</sup>) or primary Sjögren's syndrome (OR 0.1 [0.06-0.2], <i>p</i> < 10<sup>-4</sup>).
|
30915082 |
2019 |
Lupus Erythematosus, Discoid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Neonatal lupus erythematosus (NLE) is a distinct subset of lupus characterized by cutaneous findings (50%), cardiac conduction defects (50%), and autoantibodies to Ro (SS-A) antigen.
|
1444503 |
1992 |
Lupus Erythematosus, Discoid
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Up-regulated expression of Ro52/tripartite motif-containing protein 21 (TRIM21), Ro60/TROVE domain family, member 2 (TROVE2) and lupus LA protein/Sjögren's syndrome antigen B (La/SSB) autoantigens has been described in the salivary gland epithelial cells (SGEC) of patients with Sjögren's syndrome (SS).
|
25098814 |
2014 |
Lupus Erythematosus, Discoid
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Of the two autoantibodies studied, anti-Ro/anti-SSA levels in borderline lupus patients appeared as an important parameter for monitoring/diagnosis of lupus patients.
|
23832290 |
2013 |
Lupus Erythematosus, Discoid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Loss of the lupus autoantigen Ro52/Trim21 induces tissue inflammation and systemic autoimmunity by disregulating the IL-23-Th17 pathway.
|
19635858 |
2009 |
Lupus Erythematosus, Discoid
|
0.100 |
Biomarker
|
disease |
BEFREE |
The results of this study indicate that the antigenic determinants on Ro52 are different for autoantibodies produced by lupus patients compared with those of SS patients.
|
7693382 |
1993 |
Lupus Erythematosus, Discoid
|
0.100 |
Biomarker
|
disease |
BEFREE |
These data demonstrate that anti-Ro(SS-A)/La(SS-B) positive Sjogren's/lupus overlap patients and neonatal lupus syndrome mothers are immunogenetically closely related to each other and appear to be more closely related to both primary Sjogren's syndrome and subacute lupus erythematosus, than to classical systemic lupus erythematosus.
|
2584740 |
1989 |
Lupus Erythematosus, Discoid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Genetic knock out of 60kD Ro (or SSA), a common lupus autoantigen, induces lupus.
|
14698275 |
2004 |
Lupus Erythematosus, Systemic
|
0.100 |
Biomarker
|
disease |
BEFREE |
Anti-SS-A/Ro antibodies are commonly found in systemic autoimmune diseases such as Sjögren's syndrome and systemic lupus erythematosus, and some of these antibodies appear to be responsible for certain pathological lesions including congenital heart block in neonatal lupus.
|
9125110 |
1997 |
Lupus Erythematosus, Systemic
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These findings suggest that the increased expression of the Ro52 autoantigen in patients may be directly involved in the reduced cellular proliferation and increased apoptotic cell death observed in Sjögren's syndrome and SLE, and may thus contribute to the autoantigenic load and induction of autoimmune B and T cell responses observed in rheumatic patients.
|
16670339 |
2006 |
Lupus Erythematosus, Systemic
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Additionally, rs4963128 and rs2246614 were correlated with a variety of clinical subphenotypes, such as lupus nephritis, arthritis, and the production of anti-SSA/B autoantibodies, despite a lack of significant association between these two SNPs and SLE disease susceptibility in general.
|
21167895 |
2011 |
Lupus Erythematosus, Systemic
|
0.100 |
Biomarker
|
disease |
BEFREE |
Patients with isolated anti-Ro52 had a wider variety of diseases associated, but among auto-immune diseases they were more prone to inflammatory myositis (OR 10.5 [1.4-81.7], <i>p</i> = 0.02) and inflammatory rheumatism (OR 4.6 [1.6-13.8], <i>p</i> = 0.006) in contrast to systemic lupus (OR 0.2 [0.1-0.3], <i>p</i> < 10<sup>-4</sup>) or primary Sjögren's syndrome (OR 0.1 [0.06-0.2], <i>p</i> < 10<sup>-4</sup>).
|
30915082 |
2019 |