|
Acquired long QT syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
These findings provide novel insights into hERG regulation and anti-Ro52 antibody-associated LQTS.
|
30544220 |
2019 |
|
Acromegaly
|
0.020 |
Biomarker
|
disease |
BEFREE |
Pegvisomant is a more cost-effective alternative for the treatment of acromegaly in FG SSA-resistant patients in the Spanish NHS.
|
31055976 |
2019 |
|
Acromegaly
|
0.020 |
Biomarker
|
disease |
BEFREE |
Oral glucose tolerance testing (OGTT) was performed on 64 newly diagnosed and treatment-naïve patients with acromegaly both at pretreatment and 3 months after initiation of treatment with long-acting SSA.
|
29853879 |
2018 |
|
Acute Chagas' disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
RNA interference by the Clone 36 transcripts is hypothesized as a mechanism for host immune suppression during acute Chagas' disease and/or for autoimmunity in chronic Chagas' disease through down-regulation of Ro52.
|
20709399 |
2011 |
|
Acute infectious disease
|
0.010 |
Biomarker
|
group |
BEFREE |
While TRIM21 deficient mice exhibited a decreased IFN-β production, an increased cardiac and pancreatic CVB3 replication, and aggravated pancreatic injury as well as myocarditis during acute infection.
|
30410495 |
2018 |
|
Adenoma
|
0.100 |
Biomarker
|
group |
BEFREE |
The gut microbiome, including relative abundance of Fusobacteria, did not differ between TA and SSA/P, suggesting that Fusobacteria may contribute to both the serrated pathway and the adenoma-carcinoma sequence.
|
27125587 |
2016 |
|
Adenoma
|
0.100 |
Biomarker
|
group |
BEFREE |
In addition, observed association between SSA/P with advanced conventional neoplasia (but not low-grade adenomas) suggests 2 distinct groups of patient predisposition, one with both advanced conventional and important serrated precursors (SSA/P) and the other largely restricted to nonadvanced conventional adenomas and HPs only.
|
28723863 |
2018 |
|
Adenoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
A BRAF mutation was present in 82% of serrated carcinomas (SCas), 62% of serrated adenomas (SAs), 83% of serrated polyps with abnormal proliferation (SPAPs-syn. sessile serrated adenoma [SSA]), 76% of microvesicular serrated polyps (MVSPs), and was not found in any of the histologic categories of the traditional adenoma-carcinoma sequence.
|
17122504 |
2006 |
|
Adenoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We consider pedunculated serrated polyp showing features of SSA/P as a previously undescribed form of serrated adenoma/polyp in the spectrum of serrated neoplasia, which might represent a pedunculated variant of SSA/P or a precursor lesion of proximally located traditional serrated adenomas in the earliest stage.
|
23648458 |
2013 |
|
Adenoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Most of the polyps (83%) were serrated polyps: microvesicular hyperplastic polyps (HP) (n=156), goblet cell HP (n=25), sessile serrated adenoma/polyps (SSA/P) (n=110), SSA/P with cytologic dysplasia (n=28), and traditional serrated adenomas (n=18).
|
22510757 |
2012 |
|
Adenoma
|
0.100 |
Biomarker
|
group |
BEFREE |
To determine whether an educational intervention that improved adenoma detection rate (ADR) could improve SSA/P detection rate after reclassification of previously termed "hyperplastic" polyps.
|
28444509 |
2017 |
|
Adenoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Its sensitivity for advanced precancers (AA and SSA) ≥1 cm was 57%, for >2 cm it was 73%, and for >3 cm it was 83%.
|
23639600 |
2013 |
|
Adenoma
|
0.100 |
Biomarker
|
group |
BEFREE |
BRAF mutation was more frequent, whereas KRAS mutation was less frequent in the SSA/P series as compared with the adenoma series.
|
24925057 |
2015 |
|
Adenoma
|
0.100 |
Biomarker
|
group |
BEFREE |
These findings support the possibility of annual colonoscopic surveillance, consideration for colectomy when SSA/P or adenomas are encountered and frequent postoperative endoscopic surveillance of the retained colorectum.
|
22490521 |
2013 |
|
Adenoma
|
0.100 |
Biomarker
|
group |
BEFREE |
The 30 seconds additional observation with LCI improved the detection of adenoma and SSA/P in the right-sided colon.
|
30116263 |
2018 |
|
Adenoma of large intestine
|
0.020 |
Biomarker
|
disease |
BEFREE |
Traditional serrated adenoma (TSA) remains the least understood of all the colorectal adenomas, although these lesions have been associated with a significant cancer risk, twice that of the conventional adenoma (CAD) and of the sessile serrated adenoma (SSA/P).
|
31729028 |
2020 |
|
Adenoma of large intestine
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
In this report, we focused on colorectal adenoma (tubular or tubulovillous adenoma), or tubular early carcinoma or type 2 adenocarcinoma, familial adenomatous polyposis (FAP), ulcerative colitis-associated tumor (UCAT), and sessile serrated adenoma/polyp (SSA/P).
|
29564561 |
2018 |
|
Adenomatous Polyposis Coli
|
0.020 |
Biomarker
|
disease |
BEFREE |
The pattern of TTR-derived amyloid deposition in the gastrointestinal tract in SSA and in FAP are quite different.
|
19626481 |
2009 |
|
Adenomatous Polyposis Coli
|
0.020 |
Biomarker
|
disease |
BEFREE |
The expression levels of miR-7 and -21 were up-regulated in non-granular type of laterally spreading tumor, UCAT, and SSA/P compared with those in polypoid and FAP tumors.
|
29564561 |
2018 |
|
Adenomatous Polyps
|
0.010 |
Biomarker
|
disease |
BEFREE |
Although large SSA/Ps are generally recognized phenotypically, small (<1 cm) or dysplastic SSA/Ps are difficult to differentiate from hyperplastic or small adenomatous polyps by endoscopy and histopathology.
|
24533081 |
2014 |
|
Adult Liver Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We validated that TRIM21 was downregulated in liver cancer samples by immunohistochemical (IHC) staining.
|
26055142 |
2015 |
|
Adult Lymphoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
<i>HCP5</i> rs3099844 was associated with anti-SSA (<i>P</i> = 0.006, OR = 3.07) and anti-SSB (<i>P</i> = 0.005, OR = 2.66) antibodies, severity of focus score (<i>P</i> = 0.03, OR = 12), and lymphoma development (<i>P</i> = 0.002, OR = 7.23).
|
30882006 |
2019 |
|
Adult type dermatomyositis
|
0.050 |
Biomarker
|
disease |
BEFREE |
In exact logistic regressions adjusted for age, race/ethnicity, sex, amyopathic status, anti-Ro52 status, and dermatomyositis-associated cancer, the presence of anti-SAE-1/2 autoantibodies was significantly associated with a hydroxychloroquine-associated skin eruption (odds ratio [OR], 8.43; 95% CI, 1.98-49.19; P = .003) and presence of anti-MDA-5 autoantibodies was significantly negatively associated with a hydroxychloroquine-associated skin eruption (OR, 0.06; 95% CI, 0.0004-0.52; P = .006).
|
30140893 |
2018 |
|
Adult type dermatomyositis
|
0.050 |
Biomarker
|
disease |
BEFREE |
The overrepresentation of DM in those with preceding vaccination and the possible role of antibodies to Ro52 in susceptibility to vaccine-induced myositis require confirmation.Muscle Nerve 56: 987-989, 2017.
|
28224635 |
2017 |
|
Adult type dermatomyositis
|
0.050 |
Biomarker
|
disease |
BEFREE |
To describe and expand the phenotype of isolated anti-Ro-52-associated rapid progressive interstitial lung disease (RP-ILD) in Dermatomyositis(DM) in Chinese patients.
|
31344662 |
2019 |