|
Congenital heart block
|
0.100 |
Biomarker
|
disease |
BEFREE |
To date, there is a universal association of CCHB with maternal antibodies to SSA/Ro-SSB/La ribonucleoproteins, detectable by high ratio monomer:crosslinker SDS-immunoblot.
|
1285897 |
1993 |
|
Lupus Vulgaris
|
0.100 |
Biomarker
|
disease |
BEFREE |
Neonatal lupus erythematosus (NLE) is a distinct subset of lupus characterized by cutaneous findings (50%), cardiac conduction defects (50%), and autoantibodies to Ro (SS-A) antigen.
|
1444503 |
1992 |
|
Lupus Erythematosus, Discoid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Neonatal lupus erythematosus (NLE) is a distinct subset of lupus characterized by cutaneous findings (50%), cardiac conduction defects (50%), and autoantibodies to Ro (SS-A) antigen.
|
1444503 |
1992 |
|
Lupus Erythematosus, Systemic
|
0.100 |
Biomarker
|
disease |
BEFREE |
Neonatal lupus erythematosus (NLE) is a distinct subset of lupus characterized by cutaneous findings (50%), cardiac conduction defects (50%), and autoantibodies to Ro (SS-A) antigen.
|
1444503 |
1992 |
|
Lupus Erythematosus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Neonatal lupus erythematosus (NLE) is a distinct subset of lupus characterized by cutaneous findings (50%), cardiac conduction defects (50%), and autoantibodies to Ro (SS-A) antigen.
|
1444503 |
1992 |
|
Neonatal Systemic lupus erythematosus
|
0.100 |
Biomarker
|
disease |
BEFREE |
The spectrum of cutaneous disease in U1RNP antibody-positive infants is similar to Ro (SS-A) antibody-positive infants with NLE.
|
1444503 |
1992 |
|
Conduction disorder of the heart
|
0.010 |
Biomarker
|
group |
BEFREE |
Neonatal lupus erythematosus (NLE) is a distinct subset of lupus characterized by cutaneous findings (50%), cardiac conduction defects (50%), and autoantibodies to Ro (SS-A) antigen.
|
1444503 |
1992 |
|
Neonatal Systemic lupus erythematosus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Examination of paternal and maternal C4 genes of additional infants with NLE, in particular those with CCHB, and of normal infants born to anti-Ro(SS-A)-positive mothers--and of the normal infants' parents--is required to determine if abnormal C4B genes are a critical factor rendering susceptibility to the NLE syndrome.
|
1545698 |
1992 |
|
Protein Deficiency
|
0.010 |
Biomarker
|
disease |
BEFREE |
No significant increase in C4A or C4B null allotypes or protein deficiencies was noted in mothers of infants with neonatal lupus when compared with anti-Ro(SS-A)-positive mothers delivered of clinically normal infants.
|
1545698 |
1992 |
|
Neonatal Systemic lupus erythematosus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, a mother with positive anti-SSA and SSB antibodies can give birth to one infant with and one infant without or have two infants with neonatal lupus erythematosus.
|
1607484 |
1992 |
|
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
The three mothers were found to suffer from Sjögren's syndrome; they all tested positive for anti-SSA and SSB antibodies and had lymphocyte infiltration into the small salivary gland.
|
1607484 |
1992 |
|
Congenital heart block
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In the sera of these three women circulating anti-SS-A (Ro) antibodies were detected, which are known to be associated with congenital heart block.
|
1881495 |
1991 |
|
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Anti-Ro/SS-A antibodies are commonly found in the sera of patients with Sjögren's syndrome and SLE.
|
1919005 |
1991 |
|
Lupus Erythematosus, Systemic
|
0.100 |
Biomarker
|
disease |
BEFREE |
Anti-Ro(SSA) autoantibodies are associated with T cell receptor beta genes in systemic lupus erythematosus patients.
|
1967259 |
1990 |
|
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Multiple molecular histocompatibility mechanisms are implicated, therefore, in the production of anti-Ro/SSA autoantibodies in autoimmune disease.
|
1974555 |
1990 |
|
Lupus Erythematosus, Systemic
|
0.100 |
Biomarker
|
disease |
BEFREE |
For anti-Ro/SSA autoantibodies in SLE, and perhaps more generally, these data show that the histocompatibility antigens are among the elements that confer autoimmune response specificity and restrict the production of particular autoantibodies among patients with systemic lupus erythematosus.
|
1974555 |
1990 |
|
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings contrast with the relatively homogeneous immunogenetic background seen in other lupus erythematosus subsets with a high frequency of Ro(SS-A) antibody, i.e., neonatal lupus erythematosus and Sjögren's syndrome/lupus erythematosus overlap (increased frequency of HLA-DR3, DQw2 and DRW52).
|
2031665 |
1991 |
|
Lupus Erythematosus, Subacute Cutaneous
|
0.030 |
Biomarker
|
disease |
BEFREE |
The increased frequency of HLA-DR2 and DR3 appears to be associated with expression of the Ro(SS-A) antibody, since no HLA associations were seen in Ro(SS-A)-negative SCLE patients when compared with normal population controls.
|
2031665 |
1991 |
|
Familial Mediterranean Fever
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Sera samples of 168 patients with familial Mediterranean fever (FMF) and their 184 first degree relatives were analyzed for the presence of autoantibodies to ssDNA, dsDNA, poly (I), poly (G), cardiolipin, histones, RNP and Ro(SSA), using an enzyme linked immunosorbent assay (ELISA).
|
2066952 |
1991 |
|
Lupus Erythematosus, Systemic
|
0.100 |
Biomarker
|
disease |
BEFREE |
Using molecular genetic tools in serologically homogeneous patient populations, and across racial lines, the Ro (SS-A) and la (SS-B) autoantibody responses in systemic lupus erythematosus and Sjögren's syndrome appear to associate most strongly with HLA-DQ alleles, whereas the anti-Jo-1 autoantibody in myositis correlates best with HLA-DRw52.
|
2462349 |
1988 |
|
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Using molecular genetic tools in serologically homogeneous patient populations, and across racial lines, the Ro (SS-A) and la (SS-B) autoantibody responses in systemic lupus erythematosus and Sjögren's syndrome appear to associate most strongly with HLA-DQ alleles, whereas the anti-Jo-1 autoantibody in myositis correlates best with HLA-DRw52.
|
2462349 |
1988 |
|
Myositis
|
0.050 |
Biomarker
|
disease |
BEFREE |
Using molecular genetic tools in serologically homogeneous patient populations, and across racial lines, the Ro (SS-A) and la (SS-B) autoantibody responses in systemic lupus erythematosus and Sjögren's syndrome appear to associate most strongly with HLA-DQ alleles, whereas the anti-Jo-1 autoantibody in myositis correlates best with HLA-DRw52.
|
2462349 |
1988 |
|
Sjogren's Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Because the SS-A/Ro and SS-B/La autoantibody responses in SS and systemic lupus erythematosus (SLE) show even stronger correlations with HLA alleles, HLA-DR and DQ alleles were examined using restriction fragment length polymorphisms (RFLP) in white and black patients with SS and/or SS having anti-Ro and anti-La antibodies.
|
2571337 |
1989 |
|
Trichohepatoenteric Syndrome
|
0.020 |
Biomarker
|
disease |
BEFREE |
The syndrome is believed to be caused by transplacental passage of an IgG antibody, usually the anti-Ro (SS-A) antibody, from the mother to the infant.
|
2579661 |
1985 |
|
Lupus Vulgaris
|
0.100 |
Biomarker
|
disease |
BEFREE |
These data demonstrate that anti-Ro(SS-A)/La(SS-B) positive Sjogren's/lupus overlap patients and neonatal lupus syndrome mothers are immunogenetically closely related to each other and appear to be more closely related to both primary Sjogren's syndrome and subacute lupus erythematosus, than to classical systemic lupus erythematosus.
|
2584740 |
1989 |