|
Inflammatory Bowel Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Germline loss-of-function mutations are known to cause hyper-IgE immunodeficiency (autosomal dominant hyper IgE syndrome), whereas somatic gain-of-function mutations have been described in large granular cell leukemia, and polymorphisms in STAT3 have been associated with inflammatory bowel disease and other solid organ tumors.
|
26574998 |
2016 |
|
Inflammatory Bowel Diseases
|
0.400 |
GeneticVariation
|
group |
GWASCAT |
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.
|
26192919 |
2015 |
|
Inflammatory Bowel Diseases
|
0.400 |
GeneticVariation
|
group |
GWASCAT |
Identification of Loci at 1q21 and 16q23 That Affect Susceptibility to Inflammatory Bowel Disease in Koreans.
|
27569725 |
2016 |
|
Inflammatory Bowel Diseases
|
0.400 |
GeneticVariation
|
group |
GWASCAT |
Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease.
|
28067908 |
2017 |
|
Inflammatory Bowel Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
JAK2 and STAT3 polymorphisms have been implicated to be associated with inflammatory bowel disease, which might share common immunogenesis and genetic factors with AS.
|
20627814 |
2010 |
|
Inflammatory Bowel Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Consistent with epidemiologic predictions, many IBD-associated loci demonstrate genome-wide significant associations to both CD and UC, notably, genes whose products function in the interleukin-23 pathway, and transcription factors, including NK2 transcription factor related, locus 3 (NKX2-3), SMAD3, STAT3, ZMIZ1, and c-REL.
|
21530736 |
2011 |
|
Inflammatory Bowel Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The aim of our study is to investigate the involvement of IL23R, JAK2, and STAT3 polymorphisms in inflammatory bowel diseases in a Turkish population.
|
27852544 |
2016 |
|
Inflammatory Bowel Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Other than genetic variants of IL-10 receptors, IL-10 and STAT3 genes are also associated with IBD, emphasizing the involvement of the IL-10 signalling cascade in the pathogenesis of CD and UC.
|
21631466 |
2012 |
|
Inflammatory Bowel Diseases
|
0.400 |
GeneticVariation
|
group |
GWASCAT |
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
|
23128233 |
2012 |
|
Inflammatory Bowel Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
These data suggest that the STAT3 locus is associated with both IBD and cancer.
|
25132422 |
2014 |
|
Inflammatory Bowel Diseases
|
0.400 |
GeneticVariation
|
group |
GWASDB |
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
|
23128233 |
2012 |
|
Inflammatory Bowel Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The propensity to develop IBD has not been linked to single gene mutations in most instances, but has been linked to SNP in the NOD2 locus (which appear to create hypomorphic alleles for this bacterial response gene), the IL23R locus, the autophagy gene ATG16L1 and a wide range of other loci including the Toll-like receptors, JAK2 and STAT3, and perhaps 70 more.
|
21088407 |
2010 |
|
Inflammatory Bowel Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The originally described association of IBD with STAT3 polymorphisms is corroborated for the two clinical phenotypes, CD and UC, in an independent population.
|
20200543 |
2010 |
|
Inflammatory Bowel Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
STAT3 in immune responses and inflammatory bowel diseases.
|
16474436 |
2006 |
|
Inflammatory Bowel Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Germline variation in IL23R, IL12B, JAK2 and STAT3 is associated with inflammatory bowel disease susceptibility, consistent with the newly described role for IL23 signaling and Th17 cells in disease pathogenesis.
|
19817673 |
2009 |
|
Inflammatory Bowel Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
STAT3 tyrosine phosphorylation (pSTAT3) was measured in circulating leukocytes by flow cytometry, and mechanisms regulating STAT3 activation were tested in IBD Epstein-Barr virus (EBV)-transformed lymphocytes (EBL).
|
22197944 |
2012 |
|
Inflammatory Bowel Diseases
|
0.400 |
Biomarker
|
group |
MGD |
|
|
|
|
Inflammatory Bowel Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
The cis-expression quantitative trait locus analysis showed little evidence for correlation between genetic risk load and mRNA expression of Th17/IL23 genes, because we identified for only 2 of 22 Th17/IL23 genes a cis-expression quantitative trait locus single nucleotide polymorphism that is also associated to IBD (STAT3 and CCR6).
|
24662057 |
2014 |
|
Inflammatory Bowel Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
A20 ameliorates inflammatory bowel disease in mice via inhibiting NF-κB and STAT3 activation.
|
29608924 |
2018 |
|
Inflammatory Bowel Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Immune deficiency vs. immune excess in inflammatory bowel diseases-STAT3 as a rheo-STAT of intestinal homeostasis.
|
26232455 |
2016 |
|
Inflammatory Bowel Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
T helper 17 (Th17)-cell differentiation triggered by interleukin-6 (IL-6) via STAT3 activation promotes inflammation in inflammatory bowel disease (IBD) patients.
|
30770344 |
2019 |
|
Inflammatory Bowel Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Moreover, low level of HMGB1 was correlated with reduced nuclear STAT3 and enhanced p-STAT3 in inflamed intestine of <i>il10<sup>-/-</sup></i> mice and inflammatory bowel disease (IBD) patients.
|
30894054 |
2019 |
|
Inflammatory Bowel Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Job's (hyper IgE) syndrome or inflammatory bowel disease (IBD) have now established a clear-cut role for the IL-10/STAT3 axis in immune tolerance; further understanding of these processes could lead to novel therapeutic approaches for autoimmune diseases.
|
28631311 |
2017 |
|
Inflammatory Bowel Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Blockade of ROCK2 activity using Slx-2119 significantly suppressed proinflammatory cytokines in inflamed mucosa from IBD patients including IFX-unresponsive CD patients, and inhibited IBD CD4<sup>+</sup> T cells to differentiate into Th1 and Th17 cells through downregulating phosphorylated Stat1 and Stat3, but promoted Treg cell differentiation through upregulating phosphorylated Stat5.
|
29269245 |
2018 |
|
Inflammatory Bowel Diseases
|
0.400 |
Biomarker
|
group |
LHGDN |
We also found association with JAK2 and replicated a recently reported association with STAT3, further implicating the role of this signaling pathway in inflammatory bowel disease.
|
19068216 |
2009 |