|
Inflammatory Bowel Diseases
|
0.400 |
Biomarker
|
group |
MGD |
|
|
|
|
Inflammatory Bowel Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
STAT3 in immune responses and inflammatory bowel diseases.
|
16474436 |
2006 |
|
Inflammatory Bowel Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
A proinflammatory IL6:STAT3 biologic network is upregulated in active pediatric IBD patients at diagnosis and during therapy.
|
18069684 |
2008 |
|
Inflammatory Bowel Diseases
|
0.400 |
Biomarker
|
group |
LHGDN |
We also found association with JAK2 and replicated a recently reported association with STAT3, further implicating the role of this signaling pathway in inflammatory bowel disease.
|
19068216 |
2009 |
|
Inflammatory Bowel Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
We also found association with JAK2 and replicated a recently reported association with STAT3, further implicating the role of this signaling pathway in inflammatory bowel disease.
|
19068216 |
2009 |
|
Inflammatory Bowel Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
IL-24 derived from colonic SEMFs acts on colonic epithelial cells to elicit JAK1/STAT-3 activation and the expression of SOCS3 and mucins, supporting their suppressive effects on mucosal inflammation in IBD.
|
19535621 |
2009 |
|
Inflammatory Bowel Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Germline variation in IL23R, IL12B, JAK2 and STAT3 is associated with inflammatory bowel disease susceptibility, consistent with the newly described role for IL23 signaling and Th17 cells in disease pathogenesis.
|
19817673 |
2009 |
|
Inflammatory Bowel Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The originally described association of IBD with STAT3 polymorphisms is corroborated for the two clinical phenotypes, CD and UC, in an independent population.
|
20200543 |
2010 |
|
Inflammatory Bowel Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
JAK2 and STAT3 polymorphisms have been implicated to be associated with inflammatory bowel disease, which might share common immunogenesis and genetic factors with AS.
|
20627814 |
2010 |
|
Inflammatory Bowel Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The propensity to develop IBD has not been linked to single gene mutations in most instances, but has been linked to SNP in the NOD2 locus (which appear to create hypomorphic alleles for this bacterial response gene), the IL23R locus, the autophagy gene ATG16L1 and a wide range of other loci including the Toll-like receptors, JAK2 and STAT3, and perhaps 70 more.
|
21088407 |
2010 |
|
Inflammatory Bowel Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Consistent with epidemiologic predictions, many IBD-associated loci demonstrate genome-wide significant associations to both CD and UC, notably, genes whose products function in the interleukin-23 pathway, and transcription factors, including NK2 transcription factor related, locus 3 (NKX2-3), SMAD3, STAT3, ZMIZ1, and c-REL.
|
21530736 |
2011 |
|
Inflammatory Bowel Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Other than genetic variants of IL-10 receptors, IL-10 and STAT3 genes are also associated with IBD, emphasizing the involvement of the IL-10 signalling cascade in the pathogenesis of CD and UC.
|
21631466 |
2012 |
|
Inflammatory Bowel Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
STAT3 tyrosine phosphorylation (pSTAT3) was measured in circulating leukocytes by flow cytometry, and mechanisms regulating STAT3 activation were tested in IBD Epstein-Barr virus (EBV)-transformed lymphocytes (EBL).
|
22197944 |
2012 |
|
Inflammatory Bowel Diseases
|
0.400 |
GeneticVariation
|
group |
GWASCAT |
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
|
23128233 |
2012 |
|
Inflammatory Bowel Diseases
|
0.400 |
GeneticVariation
|
group |
GWASDB |
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
|
23128233 |
2012 |
|
Inflammatory Bowel Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
The cis-expression quantitative trait locus analysis showed little evidence for correlation between genetic risk load and mRNA expression of Th17/IL23 genes, because we identified for only 2 of 22 Th17/IL23 genes a cis-expression quantitative trait locus single nucleotide polymorphism that is also associated to IBD (STAT3 and CCR6).
|
24662057 |
2014 |
|
Inflammatory Bowel Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
These data suggest that the STAT3 locus is associated with both IBD and cancer.
|
25132422 |
2014 |
|
Inflammatory Bowel Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Therefore, mTORC1 signaling critically protects against inflammatory bowel disease through modulation of inflammation-induced Stat3 activity.
|
26026060 |
2015 |
|
Inflammatory Bowel Diseases
|
0.400 |
GeneticVariation
|
group |
GWASCAT |
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.
|
26192919 |
2015 |
|
Inflammatory Bowel Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Immune deficiency vs. immune excess in inflammatory bowel diseases-STAT3 as a rheo-STAT of intestinal homeostasis.
|
26232455 |
2016 |
|
Inflammatory Bowel Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Additional suggestive associations (P < 4.2 × 10(-5)) were observed between Crohn's disease and IBD and African-specific SNPs in STAT5A and STAT3; between IBD and SNPs in IL23R, IL12B, and C2orf43; and between ulcerative colitis and SNPs near HDAC11 and near LINC00994.
|
26278503 |
2015 |
|
Inflammatory Bowel Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Germline loss-of-function mutations are known to cause hyper-IgE immunodeficiency (autosomal dominant hyper IgE syndrome), whereas somatic gain-of-function mutations have been described in large granular cell leukemia, and polymorphisms in STAT3 have been associated with inflammatory bowel disease and other solid organ tumors.
|
26574998 |
2016 |
|
Inflammatory Bowel Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Some IBD associated genes are involved in innate immunity, in the autophagy and in the inflammatory response such as NOD2, ATG16L1 and IL23R, while other are implicated in immune mediated disease (STAT3) and in susceptibility to mycobacterium infection (IL12B).
|
26604638 |
2015 |
|
Inflammatory Bowel Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
STAT3 is activated in chronically inflamed intestines in human inflammatory bowel diseases and in colitis-associated colon cancer.
|
27237322 |
2016 |
|
Inflammatory Bowel Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
To establish the prevalence of the single nucleotide polymorphisms (SNPs) of endoplasmic reticulum aminopeptidase 1 (ERAP1), IL-23 receptor (IL-23R), signal transducer and activator of transcription 3 (STAT-3) and Janus kinase 2 (JAK-2) in ankylosing spondylitis (AS) and inflammatory bowel disease (IBD) in a Turkish population.
|
27458846 |
2016 |