Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0000737
Disease: Abdominal Pain
Abdominal Pain 		0.100 Biomarker phenotype HPO
CUI: C4021790
Disease: Abnormality of the skeletal system
Abnormality of the skeletal system 		0.020 Biomarker disease BEFREE Autosomal dominant hyper IgE (HIES or Job's) syndrome is a rare primary immune deficiency characterized by eczema, recurrent skin and lung infections, extremely elevated serum IgE, and a variety of connective tissue and skeletal abnormalities. 19036057 2009
CUI: C4021790
Disease: Abnormality of the skeletal system
Abnormality of the skeletal system 		0.020 GeneticVariation disease BEFREE Autosomal dominant HIES, the most common disease in this group, results from STAT3 mutations and has a variety of connective tissue and skeletal abnormalities. 18424333 2008
CUI: C0001175
Disease: Acquired Immunodeficiency Syndrome
Acquired Immunodeficiency Syndrome 		0.010 Biomarker group BEFREE Integration of HIV-1 caused STAT3-associated B cell lymphoma in an AIDS patient. 18024124 2008
CUI: C0022602
Disease: Actinic keratosis
Actinic keratosis 		0.010 Biomarker disease BEFREE Our data suggest that miR-204 may act as a "rheostat" that controls the signalling towards the MAPK pathway or the STAT3 pathway in the progression from AK to cSCC. 27457246 2016
CUI: C1333296
Disease: Activated B-cell type diffuse large B-cell lymphoma
Activated B-cell type diffuse large B-cell lymphoma 		0.020 AlteredExpression disease BEFREE In this study, we have compared by means of RNAscope technology STAT3 RNA expression in human DLBCL in a selected group of activated B-cell-like DLBCL (ABC-DLBCL) patients with another group of germinal center B-cell-like DLBCL (GBC-DLBCL) patients. 30639963 2019
CUI: C1333296
Disease: Activated B-cell type diffuse large B-cell lymphoma
Activated B-cell type diffuse large B-cell lymphoma 		0.020 AlteredExpression disease BEFREE Based on this signature, we constructed a molecular predictor of STAT3 signaling that defined a subset of ABC DLBCL tumors with high expression of STAT3, IL-6, and/or IL-10 and their downstream targets. 18160665 2008
CUI: C0742343
Disease: Acute Chest Syndrome
Acute Chest Syndrome 		0.010 Biomarker disease BEFREE Using the pharmaceutical inhibitor TG101348 or knockdown of STAT3 reduced the number of Th17 cells while promoting the number and function of Treg cells via the Janus kinase2 (JAK2)/STAT3 pathway in ACS patients. 25572535 2015
CUI: C2118460
Disease: Acute colitis
Acute colitis 		0.010 AlteredExpression disease BEFREE Le Carbone, a charcoal supplement, modulates DSS-induced acute colitis in mice through activation of AMPKα and downregulation of STAT3 and caspase 3 dependent apoptotic pathways. 27978459 2017
CUI: C0948089
Disease: Acute Coronary Syndrome
Acute Coronary Syndrome 		0.010 AlteredExpression disease BEFREE Modulation of STAT3 and STAT5 activity rectifies the imbalance of Th17 and Treg cells in patients with acute coronary syndrome. 25572535 2015
CUI: C0023440
Disease: Acute Erythroblastic Leukemia
Acute Erythroblastic Leukemia 		0.060 Biomarker disease BEFREE Thus, Stat1 and Stat3 may support cell growth in part via c-myc gene activation in primary erythroleukemia cells. 11843291 2002
CUI: C0023440
Disease: Acute Erythroblastic Leukemia
Acute Erythroblastic Leukemia 		0.060 Biomarker disease BEFREE Stat3 also plays an essential role in leukemic development induced by viral oncogenes, chromosomal translocations and by the Friend erythroleukemia virus. 19482615 2009
CUI: C0023440
Disease: Acute Erythroblastic Leukemia
Acute Erythroblastic Leukemia 		0.060 GeneticVariation disease BEFREE Specifically, five derivative compounds of G6 having structural similarity to the original lead compound were obtained and analyzed for their ability to (i) inhibit Jak2-V617F-mediated cell growth, (ii) inhibit the levels of phospho-Jak2, phospho-STAT3, and phospho-STAT5; (iii) induce apoptosis in human erythroleukemia cells; and (iv) suppress pathologic cell growth of Jak2-V617F-expressing human bone marrow cells ex vivo. 20667821 2010
CUI: C0023440
Disease: Acute Erythroblastic Leukemia
Acute Erythroblastic Leukemia 		0.060 Biomarker disease BEFREE First, we documented STAT3 activation by immunoblotting in AML-M6 and other AML subtypes. 16598306 2006
CUI: C0023440
Disease: Acute Erythroblastic Leukemia
Acute Erythroblastic Leukemia 		0.060 AlteredExpression disease BEFREE We found that Twist and phosphorylated STAT3 levels were promoted by the activated Notch1 receptor in human stomach adenocarcinoma SC-M1, embryonic kidney HEK293 and erythroleukemia K562 cells. 22581828 2012
CUI: C0023440
Disease: Acute Erythroblastic Leukemia
Acute Erythroblastic Leukemia 		0.060 Biomarker disease BEFREE microRNA-23a, -27a and -24 synergistically regulate JAK1/Stat3 cascade and serve as novel therapeutic targets in human acute erythroid leukemia. 27086927 2016
CUI: C0023440
Disease: Acute Erythroblastic Leukemia
Acute Erythroblastic Leukemia 		0.060 Biomarker disease LHGDN Thus, Stat1 and Stat3 may support cell growth in part via c-myc gene activation in primary erythroleukemia cells. 11843291 2002
CUI: C0856825
Disease: Acute GVH disease
Acute GVH disease 		0.050 Biomarker disease BEFREE In contrast, transfer of STAT3-deficient naive CD4(+) T cells increased FoxP3(+) Treg cells post-BMT and prevented lethality, suggesting that the consequence of STAT3 signaling may be greater for iTreg rather than nTreg cells during GvHD. 22921119 2012
CUI: C0856825
Disease: Acute GVH disease
Acute GVH disease 		0.050 Biomarker disease BEFREE Our data demonstrate that STAT3 in host myeloid cells, such as MFs, dampens acute GVHD. 28694183 2017
CUI: C0856825
Disease: Acute GVH disease
Acute GVH disease 		0.050 Biomarker disease BEFREE In the present study, the authors hypothesized that nifuroxazide, as the STAT3 inhibitor, treatment may attenuate the development of acute GvHD (aGvHD). 29152660 2017
CUI: C0856825
Disease: Acute GVH disease
Acute GVH disease 		0.050 AlteredExpression disease BEFREE We also demonstrated that HMGB1 could regulate the expression of STAT3 by modulation of its DNA methylation in CD4(+) T cells, moreover downregulated HMGB1 in aGVHD CD4(+) T cells could change the ratio of Treg/Th17. 26327693 2015
CUI: C0856825
Disease: Acute GVH disease
Acute GVH disease 		0.050 AlteredExpression disease BEFREE STAT3, a pivotal transcription factor for Th17 differentiation, is critical for T cell alloactivation in acute graft-versus-host disease (aGvHD). 30240636 2018
CUI: C0264714
Disease: Acute heart failure
Acute heart failure 		0.010 Biomarker disease BEFREE In the present study, we aimed to examine the role of the cardioprotective signal transducer and activator of transcription 3 (STAT3) in S1P mediated improved functional recovery in AHF. 29373815 2018
CUI: C0085669
Disease: Acute leukemia
Acute leukemia 		0.020 GeneticVariation disease BEFREE Our findings imply that the clonal landscape of large granular lymphocytic leukemia is more complex than considered before, and a substantial number of patients have multiple lymphocyte subclones harboring different STAT3 mutations, thus mimicking the situation in acute leukemia. 25281507 2015
CUI: C0085669
Disease: Acute leukemia
Acute leukemia 		0.020 AlteredExpression disease BEFREE Members of the Stat protein family (Stat1, Stat3 and Stat5) are constitutively activated in cells collected from some acute leukemias suggesting dysregulation of the Jak-Stat pathway. 9498707 1997