|
Cardiac Arrest
|
0.010 |
Biomarker
|
disease |
BEFREE |
Neuroprotection of RIPost was related with the activation of α7nAChR, which could suppress nuclear factor-κB and activate signal transducer and activator of transcription-3 in a rat asphyxial CA model.
|
31541709 |
2020 |
|
Sarcoidosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Constitutive STAT1 and STAT3 activation was observed in both sarcoidosis and GA, albeit in different patterns.
|
31185230 |
2020 |
|
Granuloma Annulare
|
0.010 |
Biomarker
|
disease |
BEFREE |
Constitutive STAT1 and STAT3 activation was observed in both sarcoidosis and GA, albeit in different patterns.
|
31185230 |
2020 |
|
Gestational Diabetes
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
To evaluate changes in the inflammatory response of thioredoxin (TXN), thioredoxin interacting protein (TXNIP), transducer and activator of transcription 3, NFƙB-p50 and STAT3 at the level of maternal serum, placenta, and umbilical cord blood of women with gestational diabetes mellitus type 2 (GDMA2) compared to normal pregnancies (NP).
|
31848914 |
2020 |
|
Lesion of brain
|
0.010 |
Biomarker
|
group |
BEFREE |
STAT3 phosphorylation and IL-10 expression were associated with the presence of multiple brain lesions (P = 0.004 and P = 0.027, respectively), suggesting that STAT3 activation may enhance the intracranial spread of tumors in PCNSL.
|
31778838 |
2020 |
|
Nose symptoms
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
OVA-induced AR mice exhibited increase in nasal symptoms, histological alteration, OVA-specific immunoglobulin (Ig)E/IgG1, ROR-γt, STAT3 and NF-κB signalings.
|
31669322 |
2020 |
|
Ichthyosis linearis circumflexa
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Conversely, overexpression of NS significantly promotes STAT3 phosphorylation.
|
31785228 |
2020 |
|
Skin carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Increased expression of STAT3 in human nonmelanoma skin cancer (NMSC) has been confirmed in a few studies, but to our knowledge, expression of STAT5A, STAT5B and STAT6 in BCC has not been previously evaluated.
|
31323143 |
2020 |
|
Hypospadias
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Moreover, the expression levels of TGF-β1, α-SMactin, and STAT3 were all significantly lower in hypospadias group than that in the sham-operated group (P < 0.05).
|
30380353 |
2020 |
|
Nuclear non-senile cataract
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Conversely, overexpression of NS significantly promotes STAT3 phosphorylation.
|
31785228 |
2020 |
|
Penile hypospadias
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Moreover, the expression levels of TGF-β1, α-SMactin, and STAT3 were all significantly lower in hypospadias group than that in the sham-operated group (P < 0.05).
|
30380353 |
2020 |
|
Congenital Abnormality
|
0.010 |
Biomarker
|
group |
BEFREE |
Four genes (Mtap2, Bmp8b, Stat3, and Heyl) represent candidate target genes for the underlying teratogenic mechanism responsible for VPA-induced malformations.
|
30325584 |
2019 |
|
Ascorbic Acid Deficiency
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Ascorbic acid deficiency increases hepatic expression of acute phase proteins through the intestine-derived IL-6 and hepatic STAT3 pathway in ODS rats.
|
31200316 |
2019 |
|
Aspergillosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
We aimed to assess the prevalence and describe the clinical, mycological, and radiological presentation and related therapy and outcome of Aspergillus infections of the respiratory tract in the STAT3-deficient patients of the National French cohort.
|
30878710 |
2019 |
|
Autistic Disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
The Stat3 inhibitor, S3I-201, downregulates lymphocyte activation markers, chemokine receptors, and inflammatory cytokines in the BTBR T<sup>+</sup> Itpr3<sup>tf</sup>/J mouse model of autism.
|
31299319 |
2019 |
|
Hypertrophic Cardiomyopathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Furthermore, we systematically analysed the global architecture and feature of gene regulation by miRNAs and TFs in HCM, and the FFL composed of hsa-miR-17-5p, FASN and STAT3 was inferred to play critical roles in HCM.
|
30338905 |
2019 |
|
Adenoid Cystic Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
AF1q Expression Associates with CD44 and STAT3 and Impairs Overall Survival in Adenoid Cystic Carcinoma of the Head and Neck.
|
31273546 |
2019 |
|
Dry Eye Syndromes
|
0.010 |
Biomarker
|
disease |
BEFREE |
Elevated STAT3 activation is involved in the pathogenesis of dry eye, while targeting STAT3 effectively alleviates BAC-induced ocular surface damage.
|
31503282 |
2019 |
|
Eosinophilia, Tropical
|
0.010 |
Biomarker
|
disease |
BEFREE |
In conclusion, our data showed that the inhibitory effects of sakuranetin on eosinophilic lung inflammation can be due to the inhibition of Th2 and Th17 cytokines and the inhibition of MAPK and STAT3 pathways, reinforcing the idea that sakuranetin can be considered a relevant candidate for the treatment of inflammatory allergic airway disease.
|
31565031 |
2019 |
|
Gonorrhea
|
0.010 |
Biomarker
|
disease |
BEFREE |
Specific efforts have focused on downstream anti-inflammatory effectors of GC-signaling such as GC-Induced-Leucine-Zipper (GILZ), which suppresses Th17 responses and antagonizes multiple pro-inflammatory signaling pathways involved in psoriasis, including AP-1, NF-κB, STAT3, and ROR-γt.
|
31572404 |
2019 |
|
Hernia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
We observed increased STAT3 activation prior to IVD defects and go on to demonstrate that treatment of Adgrg6 conditional mutant mice with a small molecule inhibitor of STAT3 activation ameliorates endplate-oriented herniations.
|
31652254 |
2019 |
|
Histoplasmosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Genetic defects in the interferon-gamma (IFN-γ)/STAT1 signaling pathway, CD40/CD40 ligand- and IL12/IL12-receptor-mediated crosstalk between phagocytes and T-cells, and STAT3-mediated Th17 differentiation have been reported in HIV-negative children with talaromycosis and other endemic mycoses such as histoplasmosis, coccidioidomycosis, and paracoccidioidomycosis.
|
31572394 |
2019 |
|
Childhood Acute Lymphoblastic Leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
There was a positive correlation between the expression level of STAT3 and the expression level of Treg cells in children with ALL, while that was negatively correlated with the expression levels of Treg cells.
|
31054507 |
2019 |
|
Macular Edema, Cystoid
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Papilledema can occur as a manifestation of STAT3 gain-of-function mutation, sometimes accompanied by prominent vascular sheathing and cystoid macular edema.
|
30942636 |
2019 |
|
Marek Disease
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
Interestingly, we showed that phosphorylation of STAT3 was increased during MDV infection, concomitantly with a decrease of Chk1 phosphorylation.
|
30787154 |
2019 |