GCFC2, GC-rich sequence DNA-binding factor 2, 6936

N. diseases: 21; N. variants: 13
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
Leukemia, Myelocytic, Acute
0.100 GeneticVariation disease GWASCAT Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia. 27903959 2017
CUI: C4315130
Disease: Hippocampal atrophy
Hippocampal atrophy
0.100 GeneticVariation phenotype GWASDB Multiple loci influencing hippocampal degeneration identified by genome scan. 22745009 2012
CUI: C4315130
Disease: Hippocampal atrophy
Hippocampal atrophy
0.100 GeneticVariation phenotype GWASCAT Multiple loci influencing hippocampal degeneration identified by genome scan. 22745009 2012
CUI: C0031090
Disease: Periodontal Diseases
Periodontal Diseases
0.040 Biomarker group BEFREE This systematic review aims to evaluate the literature for association and predictive value of bone turnover biomarkers in GCF during periodontal disease. 29800801 2018
CUI: C0031090
Disease: Periodontal Diseases
Periodontal Diseases
0.040 Biomarker group BEFREE The objective of the present study was to establish the utility of placental proteins presents in oral fluids (gingival crevicular fluid [GCF] and saliva), and periodontal disease status as early pregnancy predictors of GDM. 29790168 2018
CUI: C0031090
Disease: Periodontal Diseases
Periodontal Diseases
0.040 GeneticVariation group BEFREE Data suggest that the total amount and concentration of neopterin and VCAM-1 in GCF seemed to be closely associated with periodontal disease severity in CP patients with AMI. 29641752 2018
CUI: C0031090
Disease: Periodontal Diseases
Periodontal Diseases
0.040 Biomarker group BEFREE Periodontal diseases are also promising targets for proteomics, and several groups, including ours, have applied proteomics in the search for GCF biomarkers of periodontal diseases. 30587811 2018
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.020 Biomarker disease BEFREE Analysis of GCF of RA patients reveals that the relationship between periodontitis and RA is bidirectional, probably caused by a non-specific inflammatory burden. 31206910 2019
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.020 AlteredExpression disease BEFREE At all time-points, levels of inflammatory markers in GCF were higher in RA-CP than in CP patients. 29589156 2019
CUI: C0031099
Disease: Periodontitis
Periodontitis
0.020 Biomarker disease BEFREE Analysis of GCF of RA patients reveals that the relationship between periodontitis and RA is bidirectional, probably caused by a non-specific inflammatory burden. 31206910 2019
CUI: C0031099
Disease: Periodontitis
Periodontitis
0.020 Biomarker disease BEFREE Gingival crevicular fluid (GCF) biomarkers have moderate diagnostic validity in periodontitis. 31817894 2019
CUI: C0266929
Disease: Chronic Periodontitis
Chronic Periodontitis
0.020 AlteredExpression disease BEFREE At all time-points, levels of inflammatory markers in GCF were higher in RA-CP than in CP patients. 29589156 2019
CUI: C0266929
Disease: Chronic Periodontitis
Chronic Periodontitis
0.020 AlteredExpression disease BEFREE This study aimed to evaluate effects of periodontal treatment on GCF levels of neopterin and VCAM-1 in patients with chronic periodontitis (CP) with acute myocardial infarction (AMI) compared with systemically healthy CP patients. 29641752 2018
Aggressive periodontitis, generalized
0.020 Biomarker disease BEFREE Periodontal parameters and GCF biomarker levels were evaluated at baseline and repeated 3 and 6 months after treatment for GAgP subjects. 28918557 2018
CUI: C3495798
Disease: Periodontal inflammation
Periodontal inflammation
0.020 Biomarker disease BEFREE There were significant positive correlations between clinical periodontal inflammation and the presence of neopterin and VCAM-1 in GCF prior to and following periodontal treatment, and between the GCF volume and clinical parameters. 29641752 2018
CUI: C3495798
Disease: Periodontal inflammation
Periodontal inflammation
0.020 Biomarker disease BEFREE Clinical significance of GCF sIL-6R and calprotectin to evaluate the periodontal inflammation. 27810997 2017
CUI: C0920296
Disease: Developmental reading disorder
Developmental reading disorder
0.020 Biomarker disease BEFREE We aimed at discovering single nucleotide variation present in known and new candidate genes for developmental dyslexia: CYP19A1, DCDC2, DIP2A, DYX1C1, GCFC2 (also known as C2orf3), KIAA0319, MRPL19, PCNT, PRMT2, ROBO1 and S100B. 25877001 2015
CUI: C0920296
Disease: Developmental reading disorder
Developmental reading disorder
0.020 Biomarker disease BEFREE Lack of association between genetic polymorphisms in ROBO1, MRPL19/C2ORF3 and THEM2 with developmental dyslexia. 23954868 2013
Aggressive periodontitis, generalized
0.020 Biomarker disease BEFREE Relationships between subgingival microbiota and GCF biomarkers in generalized aggressive periodontitis. 20447254 2010
CUI: C0399451
Disease: Subgingival plaque
Subgingival plaque
0.010 Biomarker disease BEFREE Four and 12 weeks after implant placement and abutment connection, a dental implant and a natural tooth were sampled in 25 patients for subgingival plaque and gingival crevicular fluid (GCF [around teeth] and peri-implant crevicular fluid [PICF] around implants). 29202047 2019
CUI: C0085207
Disease: Gestational Diabetes
Gestational Diabetes
0.010 Biomarker phenotype BEFREE The objective of the present study was to establish the utility of placental proteins presents in oral fluids (gingival crevicular fluid [GCF] and saliva), and periodontal disease status as early pregnancy predictors of GDM. 29790168 2018
CUI: C0155626
Disease: Acute myocardial infarction
Acute myocardial infarction
0.010 GeneticVariation disease BEFREE Data suggest that the total amount and concentration of neopterin and VCAM-1 in GCF seemed to be closely associated with periodontal disease severity in CP patients with AMI. 29641752 2018
CUI: C0278701
Disease: Gastric Adenocarcinoma
Gastric Adenocarcinoma
0.010 Biomarker disease BEFREE The most representative taxa which were abundant in GC corresponded to the commensals or opportunistic pathogens that usually colonize the oral cavity, including genera <i>Neisseria, Alloprevotella</i>, and <i>Aggregatibacter</i>, species <i>Streptococcus_mitis_oralis_pneumoniae</i> and strain <i>Porphyromonas_endodontalis.t_GCF_000174815</i>. 30619779 2018
CUI: C0266893
Disease: Subgingival dental calculus
Subgingival dental calculus
0.010 Biomarker phenotype BEFREE MGP concentrations in GCF of patients with subgingival dental calculus were statistically higher than those without subgingival dental calculus (p=0.032). 27348051 2016
Childhood Acute Lymphoblastic Leukemia
0.010 GeneticVariation disease BEFREE Of these 1 million SNPs, six SNPs in 4 genes (HAO1 rs6140264, EPB41L2 rs9388856, rs9388857, rs1360756, C2orf3 12105972, MAN2A1 rs3776932) were strongly associated with childhood ALL risk (P(dominant)<or=0.0001 and P(trend)<0.006). 20189245 2010