MLX, MAX dimerization protein MLX, 6945

N. diseases: 40; N. variants: 5
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis 		0.340 GeneticVariation disease BEFREE Our findings suggest that the Q139R substitution in MLX plays a crucial role in the pathogenesis of TAK. 30354298 2018
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis 		0.340 Biomarker disease BEFREE We investigated the linkage between presumptive TA-related genes (FCGR2A/FCGR3A, EEFSEC, RPS9/LILRB3, RIPPLY2 and MLX) and TA in the Han Chinese population.We performed a large case-control multi-center study of 412 Han Chinese TA patients and 597 ethnically matched healthy controls. 27769046 2017
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis 		0.340 GeneticVariation disease BEFREE Four single nucleotide polymorphisms (SNPs) those locate in the IL12B region (rs56167332), the MLX region (rs665268), the FCGR2A/FCGR3A locus (rs10919543), and the HLA-B/MICA locus (rs12524487), associated with TA in different population, were genotyped in 123 Chinese TA patients and 147 healthy controls from January 2013 to August 2014. 26996483 2016
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis 		0.340 Biomarker disease BEFREE MLX and FCGR2A/3A were shown to be associated with TAK in Japanese and Turkish/American populations, respectively. 24548718 2014
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis 		0.340 SusceptibilityMutation disease ORPHANET Two susceptibility loci to Takayasu arteritis reveal a synergistic role of the IL12B and HLA-B regions in a Japanese population. 23830516 2013
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis 		0.340 SusceptibilityMutation disease ORPHANET The prevalence and characteristics of microalbuminuria in the general population: a cross-sectional study. 23830507 2013
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.100 GeneticVariation disease GWASCAT Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes. 29632382 2018
CUI: C0002871
Disease: Anemia
Anemia 		0.100 Biomarker disease HPO
CUI: C0003123
Disease: Anorexia
Anorexia 		0.100 Biomarker disease HPO
CUI: C0003862
Disease: Arthralgia
Arthralgia 		0.100 Biomarker phenotype HPO
CUI: C0003864
Disease: Arthritis
Arthritis 		0.100 Biomarker disease HPO
CUI: C0007194
Disease: Hypertrophic Cardiomyopathy
Hypertrophic Cardiomyopathy 		0.100 Biomarker disease HPO
CUI: C0008031
Disease: Chest Pain
Chest Pain 		0.100 Biomarker phenotype HPO
CUI: C0015672
Disease: Fatigue
Fatigue 		0.100 Biomarker phenotype HPO
CUI: C0015967
Disease: Fever
Fever 		0.100 Biomarker phenotype HPO
CUI: C0017086
Disease: Gangrene
Gangrene 		0.100 Biomarker disease HPO
CUI: C0019079
Disease: Hemoptysis
Hemoptysis 		0.100 Biomarker phenotype HPO
CUI: C0020458
Disease: Hyperhidrosis disorder
Hyperhidrosis disorder 		0.100 Biomarker phenotype HPO
CUI: C0020546
Disease: Hypertensive crisis
Hypertensive crisis 		0.100 Biomarker phenotype HPO
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.100 Biomarker disease HPO
CUI: C0035309
Disease: Retinal Diseases
Retinal Diseases 		0.100 Biomarker group HPO
CUI: C0036572
Disease: Seizures
Seizures 		0.100 Biomarker phenotype HPO
CUI: C0037299
Disease: Skin Ulcer
Skin Ulcer 		0.100 Biomarker phenotype HPO
CUI: C0037822
Disease: Speech Disorders
Speech Disorders 		0.100 Biomarker group HPO
CUI: C0042384
Disease: Vasculitis
Vasculitis 		0.100 Biomarker disease HPO