Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0000768
Disease: Congenital Abnormality
Congenital Abnormality 		0.050 Biomarker group BEFREE Esophageal atresia with or without tracheoesophageal fistula (EA +/- TEF) usually occurs sporadically either as an isolated malformation or in conjunction with other congenital anomalies. 6714984 1984
CUI: C1861028
Disease: Esophageal atresia with or without tracheoesophageal fistula
Esophageal atresia with or without tracheoesophageal fistula 		0.040 Biomarker disease BEFREE Esophageal atresia with or without tracheoesophageal fistula (EA +/- TEF) usually occurs sporadically either as an isolated malformation or in conjunction with other congenital anomalies. 6714984 1984
CUI: C0302142
Disease: Deformity
Deformity 		0.010 Biomarker group BEFREE Esophageal atresia with or without tracheoesophageal fistula (EA +/- TEF) usually occurs sporadically either as an isolated malformation or in conjunction with other congenital anomalies. 6714984 1984
CUI: C1861028
Disease: Esophageal atresia with or without tracheoesophageal fistula
Esophageal atresia with or without tracheoesophageal fistula 		0.040 GeneticVariation disease BEFREE Tracheoesophageal fistula, with or without esophageal atresia (TEF/EA) appears to be a defect of blastogenesis, as is the oculoauriculovertebral (Goldenhar) spectrum (OAVS), with which it has occasionally been associated. 7586653 1995
CUI: C0023418
Disease: leukemia
leukemia 		0.010 AlteredExpression disease BEFREE Thus, TEF and HLF share indistinguishable DNA-binding and transcriptional regulatory properties, whose alteration in leukemia may be pathogenetically important. 8639829 1996
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.010 AlteredExpression disease BEFREE Thus, TEF and HLF share indistinguishable DNA-binding and transcriptional regulatory properties, whose alteration in leukemia may be pathogenetically important. 8639829 1996
CUI: C0000768
Disease: Congenital Abnormality
Congenital Abnormality 		0.050 Biomarker group BEFREE These findings indicate that intestinal malrotation is more common in infants with EA/TEF than is generally perceived, and that intestinal malrotation in an infant with EA/TEF is associated with a higher burden of additional congenital anomalies, suggesting that this group of infants may have more pervasive developmental deficits and poorer prognosis than has previously been recognized. 10471893 1999
CUI: C0221210
Disease: Congenital malrotation of intestine
Congenital malrotation of intestine 		0.010 Biomarker disease BEFREE These findings indicate that intestinal malrotation is more common in infants with EA/TEF than is generally perceived, and that intestinal malrotation in an infant with EA/TEF is associated with a higher burden of additional congenital anomalies, suggesting that this group of infants may have more pervasive developmental deficits and poorer prognosis than has previously been recognized. 10471893 1999
CUI: C1608408
Disease: Malignant transformation
Malignant transformation 		0.010 Biomarker phenotype BEFREE These findings demonstrate that there are markedly abnormal expressions of TIF3 and TEF-1delta genes during malignant transformation of human bronchial epithelial cell lines induced by crystalline NiS. 16673819 2006
CUI: C0014850
Disease: Esophageal Atresia
Esophageal Atresia 		0.070 GeneticVariation disease BEFREE Shared clinical features in this group of patients include microcephaly, prenatal onset growth restriction, heart defects, tracheoesophageal fistula, and esophageal atresia (TEF/EA), skeletal anomalies, and moderate to severe global developmental delay. 21271665 2011
CUI: C0040124
Disease: Thyroglossal Cyst
Thyroglossal Cyst 		0.010 GeneticVariation disease BEFREE This case helps to further delineate the critical region for TEF/EA, which is likely confined to the chromosomal region proximal to 17q23.1, and suggests that genes in 17q23.1q23.2 may be associated with thyroglossal duct cysts. 21271665 2011
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.010 AlteredExpression phenotype BEFREE Using a Luminex-based approach to multiplex in vivo assays, we determined that the domain of YAP that interacts with the TEAD/TEF family of transcription factors but not the WW domains or PDZ-binding motif, is essential for YAP-mediated tumor growth and metastasis. 22891335 2012
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.010 GeneticVariation disease BEFREE All of them completed the PD Sleep Scale (PDSS) and other clinical and demographic assessments. rs738499, a single nucleotide polymorphism of the Tef gene, was genotyped by polymerase chain reaction-restriction fragment length polymorphism. 22257907 2012
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.100 GeneticVariation disease GWASCAT Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. 24076602 2013
CUI: C0014850
Disease: Esophageal Atresia
Esophageal Atresia 		0.070 GeneticVariation disease BEFREE Second study on the recurrence risk of isolated esophageal atresia with or without trachea-esophageal fistula among first-degree relatives: no evidence for increased risk of recurrence of EA/TEF or for malformations of the VATER/VACTERL association spectrum. 24307608 2013
CUI: C0000768
Disease: Congenital Abnormality
Congenital Abnormality 		0.050 Biomarker group BEFREE The presence of EA/TEF and malformations of the VATER/VACTERL association spectrum in relatives was systematically assessed. 24307608 2013
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.010 Biomarker disease BEFREE TNF-α modulates the expression of the Per2 gene through the D-box binding proteins DBP, HLF, TEF, and E4BP4, in rheumatoid synovial cells, and thereby may contribute to the pathogenesis of RA. 23496259 2013
CUI: C0014856
Disease: Esophageal Fistula
Esophageal Fistula 		0.010 Biomarker disease BEFREE Second study on the recurrence risk of isolated esophageal atresia with or without trachea-esophageal fistula among first-degree relatives: no evidence for increased risk of recurrence of EA/TEF or for malformations of the VATER/VACTERL association spectrum. 24307608 2013
CUI: C4225671
Disease: VATER/VACTERL ASSOCIATION
VATER/VACTERL ASSOCIATION 		0.010 Biomarker disease BEFREE The presence of EA/TEF and malformations of the VATER/VACTERL association spectrum in relatives was systematically assessed. 24307608 2013
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.320 Biomarker disease PSYGENET Cry1 and Tef gene polymorphisms are associated with major depressive disorder in the Chinese population. 24581835 2014
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.320 GeneticVariation disease BEFREE Cry1 and Tef gene polymorphisms are associated with major depressive disorder in the Chinese population. 24581835 2014
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.310 Biomarker disease PSYGENET Cry1 and Tef gene polymorphisms are associated with major depressive disorder in the Chinese population. 24581835 2014
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.310 GeneticVariation disease BEFREE Cry1 and Tef gene polymorphisms are associated with major depressive disorder in the Chinese population. 24581835 2014
CUI: C0014850
Disease: Esophageal Atresia
Esophageal Atresia 		0.070 Biomarker disease BEFREE Esophageal atresia (EA) is a congenital defect of the esophagus involving the interruption of the esophagus with or without connection to the trachea (tracheoesophageal fistula [TEF]). 24460849 2015
CUI: C0000768
Disease: Congenital Abnormality
Congenital Abnormality 		0.050 Biomarker group BEFREE The frequency of each component was: vertebral defects (V), 77 %; anal atresia (A), 62 %; tracheo-esophageal fistula/esophageal atresia (TEF/EA), 58 %; renal anomalies (R), 58 %; limb abnormalities (L), 50 %, and cardiac malformations (C), 42 %. 25008186 2015