Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Malignant neoplasm of urinary bladder
0.010 AlteredExpression disease BEFREE Analysis of TCGA data indicated that TEF mRNA was decreased in BC samples compared to that in normal bladder epithelial cells and correlated with the poor survival of BC patients. 30515906 2019
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm
0.010 AlteredExpression disease BEFREE Analysis of TCGA data indicated that TEF mRNA was decreased in BC samples compared to that in normal bladder epithelial cells and correlated with the poor survival of BC patients. 30515906 2019
CUI: C0020676
Disease: Hypothyroidism
Hypothyroidism
0.010 AlteredExpression disease BEFREE Hypothyroidism disrupted the circadian expression pattern of Bmal1 and period circadian regulator 2 (Per2) and decreased the mesor of Nr1d1 and Tef. 30747053 2019
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.010 Biomarker phenotype BEFREE Our results suggest that TEF might play an important role in suppressing BC cells proliferation and tumorigenesis. 30515906 2019
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder
0.010 AlteredExpression disease BEFREE Analysis of TCGA data indicated that TEF mRNA was decreased in BC samples compared to that in normal bladder epithelial cells and correlated with the poor survival of BC patients. 30515906 2019
Precursor B-lymphoblastic lymphoma/leukemia
0.010 GeneticVariation disease BEFREE Characterization of TCF3 rearrangements in pediatric B-lymphoblastic leukemia/lymphoma by mate-pair sequencing (MPseq) identifies complex genomic rearrangements and a novel TCF3/TEF gene fusion. 31575852 2019
CUI: C0152021
Disease: Congenital heart disease
Congenital heart disease
0.010 Biomarker group BEFREE A majority of patients undergo EA/TEF repair prior to congenital heart disease surgery.(Surgery 2017;160:XXX-XXX.). 29325785 2018
CUI: C0340213
Disease: Tracheal diverticulosis
Tracheal diverticulosis
0.010 Biomarker phenotype BEFREE Our surgical approach used complete separation of the airway and esophagus, which reliably revealed the TEF (without need for cannulation) and freed the tissues for primary closure of the trachea and frequently resection of the tracheal diverticulum. 27616617 2017
CUI: C3266262
Disease: Multiple Chronic Conditions
Multiple Chronic Conditions
0.010 GeneticVariation disease BEFREE Based on single- and multi-locus (ITS, TEF, TUB2) phylogenies, as well as morphological characters, host associations and geographical distributions, they were classified into at least 19 species in three genera, i.e. 28408743 2017
CUI: C0003466
Disease: Anus, Imperforate
Anus, Imperforate
0.010 GeneticVariation disease BEFREE The frequency of each component was: vertebral defects (V), 77 %; anal atresia (A), 62 %; tracheo-esophageal fistula/esophageal atresia (TEF/EA), 58 %; renal anomalies (R), 58 %; limb abnormalities (L), 50 %, and cardiac malformations (C), 42 %. 25008186 2015
CUI: C0239337
Disease: Deformity of limb
Deformity of limb
0.010 Biomarker group BEFREE The frequency of each component was: vertebral defects (V), 77 %; anal atresia (A), 62 %; tracheo-esophageal fistula/esophageal atresia (TEF/EA), 58 %; renal anomalies (R), 58 %; limb abnormalities (L), 50 %, and cardiac malformations (C), 42 %. 25008186 2015
CUI: C0266292
Disease: Congenital anomaly of the kidney
Congenital anomaly of the kidney
0.010 Biomarker group BEFREE The frequency of each component was: vertebral defects (V), 77 %; anal atresia (A), 62 %; tracheo-esophageal fistula/esophageal atresia (TEF/EA), 58 %; renal anomalies (R), 58 %; limb abnormalities (L), 50 %, and cardiac malformations (C), 42 %. 25008186 2015
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.010 Biomarker disease BEFREE TNF-α modulates the expression of the Per2 gene through the D-box binding proteins DBP, HLF, TEF, and E4BP4, in rheumatoid synovial cells, and thereby may contribute to the pathogenesis of RA. 23496259 2013
CUI: C0014856
Disease: Esophageal Fistula
Esophageal Fistula
0.010 Biomarker disease BEFREE Second study on the recurrence risk of isolated esophageal atresia with or without trachea-esophageal fistula among first-degree relatives: no evidence for increased risk of recurrence of EA/TEF or for malformations of the VATER/VACTERL association spectrum. 24307608 2013
CUI: C4225671
Disease: VATER/VACTERL ASSOCIATION
VATER/VACTERL ASSOCIATION
0.010 Biomarker disease BEFREE The presence of EA/TEF and malformations of the VATER/VACTERL association spectrum in relatives was systematically assessed. 24307608 2013
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.010 AlteredExpression phenotype BEFREE Using a Luminex-based approach to multiplex in vivo assays, we determined that the domain of YAP that interacts with the TEAD/TEF family of transcription factors but not the WW domains or PDZ-binding motif, is essential for YAP-mediated tumor growth and metastasis. 22891335 2012
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.010 GeneticVariation disease BEFREE All of them completed the PD Sleep Scale (PDSS) and other clinical and demographic assessments. rs738499, a single nucleotide polymorphism of the Tef gene, was genotyped by polymerase chain reaction-restriction fragment length polymorphism. 22257907 2012
CUI: C0040124
Disease: Thyroglossal Cyst
Thyroglossal Cyst
0.010 GeneticVariation disease BEFREE This case helps to further delineate the critical region for TEF/EA, which is likely confined to the chromosomal region proximal to 17q23.1, and suggests that genes in 17q23.1q23.2 may be associated with thyroglossal duct cysts. 21271665 2011
CUI: C1608408
Disease: Malignant transformation
Malignant transformation
0.010 Biomarker phenotype BEFREE These findings demonstrate that there are markedly abnormal expressions of TIF3 and TEF-1delta genes during malignant transformation of human bronchial epithelial cell lines induced by crystalline NiS. 16673819 2006
CUI: C0221210
Disease: Congenital malrotation of intestine
Congenital malrotation of intestine
0.010 Biomarker disease BEFREE These findings indicate that intestinal malrotation is more common in infants with EA/TEF than is generally perceived, and that intestinal malrotation in an infant with EA/TEF is associated with a higher burden of additional congenital anomalies, suggesting that this group of infants may have more pervasive developmental deficits and poorer prognosis than has previously been recognized. 10471893 1999
CUI: C0023418
Disease: leukemia
leukemia
0.010 AlteredExpression disease BEFREE Thus, TEF and HLF share indistinguishable DNA-binding and transcriptional regulatory properties, whose alteration in leukemia may be pathogenetically important. 8639829 1996
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia
0.010 AlteredExpression disease BEFREE Thus, TEF and HLF share indistinguishable DNA-binding and transcriptional regulatory properties, whose alteration in leukemia may be pathogenetically important. 8639829 1996
CUI: C0302142
Disease: Deformity
Deformity
0.010 Biomarker group BEFREE Esophageal atresia with or without tracheoesophageal fistula (EA +/- TEF) usually occurs sporadically either as an isolated malformation or in conjunction with other congenital anomalies. 6714984 1984
CUI: C0040588
Disease: Tracheoesophageal Fistula
Tracheoesophageal Fistula
0.020 Biomarker disease BEFREE A male infant with oesophageal atresia and distal tracheo-oesophageal fistula (TEF type C) underwent right thoracotomy and transpleural repair of TEF on day 4 of life. 30413439 2018
CUI: C0040580
Disease: Tracheal Diseases
Tracheal Diseases
0.020 Biomarker group BEFREE Our surgical approach used complete separation of the airway and esophagus, which reliably revealed the TEF (without need for cannulation) and freed the tissues for primary closure of the trachea and frequently resection of the tracheal diverticulum. 27616617 2017