|
Skin Neoplasms
|
0.700 |
Biomarker
|
group |
CTD_mouse |
Whole-Exome Sequencing Validates a Preclinical Mouse Model for the Prevention and Treatment of Cutaneous Squamous Cell Carcinoma.
|
27923803 |
2017 |
|
Skin Neoplasms
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Based on these findings, immunohistochemical results do not necessarily mean the presence or absence of p53 gene mutations in skin tumors, and sequence analysis is essential for determining whether the gene is mutated.
|
8151121 |
1994 |
|
Skin Neoplasms
|
0.700 |
GeneticVariation
|
group |
BEFREE |
In skin tumours from normal individuals, 14% of the p53 mutations are double mutations and as in XP skin tumours all these are CC-->TT transitions.
|
7513818 |
1994 |
|
Skin Neoplasms
|
0.700 |
GeneticVariation
|
group |
BEFREE |
PhIP-induced skin tumors were subjected to mutation screening, which identified genetic changes in Hras (7/40, 17.5%) and Tp53 (2/40, 5%), but not in Ctnnb1, a commonly mutated gene in PhIP-induced colon tumors.
|
28218467 |
2017 |
|
Skin Neoplasms
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Our studies have demonstrated that UV-induced mouse skin cancers contain p53 mutations at a high frequency and that these mutations can be detected in UV-irradiated mouse skin well before the appearance of skin tumors.
|
18173701 |
2008 |
|
Skin Neoplasms
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Ultraviolet-specific mutations in p53 gene in skin tumors in xeroderma pigmentosum patients.
|
8319200 |
1993 |
|
Skin Neoplasms
|
0.700 |
Biomarker
|
group |
LHGDN |
A darker side to p53.
|
17516921 |
2007 |
|
Skin Neoplasms
|
0.700 |
GeneticVariation
|
group |
BEFREE |
The data indicate that dipyrimidines that contain 5-methylcytosine are preferential targets for sunlight-induced mutagenesis in cultured mammalian cells, thus explaining the large proportion of p53 mutations at such sites in skin tumors in vivo.
|
10543945 |
1999 |
|
Skin Neoplasms
|
0.700 |
GeneticVariation
|
group |
BEFREE |
In recent years, TP53 gene mutations have been frequently observed in human skin tumors.
|
7963669 |
1994 |
|
Skin Neoplasms
|
0.700 |
GeneticVariation
|
group |
BEFREE |
In one patient, molecular analyses demonstrated that skin tumor cells had the donor genotype and harbored a TP53 mutation in codon 175.
|
23979160 |
2013 |
|
Skin Neoplasms
|
0.700 |
Biomarker
|
group |
CTD_human |
Genetic polymorphism in p53 codon 72 and skin cancer in southwestern Taiwan.
|
12635827 |
2003 |
|
Skin Neoplasms
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Specific UV-induced mutation spectrum in the p53 gene of skin tumors from DNA-repair-deficient xeroderma pigmentosum patients.
|
8248141 |
1993 |
|
Skin Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors.
|
8374952 |
1993 |
|
Skin Neoplasms
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Moreover, mutations are targeted at py-py sequences in over 90% of skin tumors whereas in internal cancers the distribution is proportional to the frequency of bipyrimidine sequences in the p53 gene.
|
7636632 |
1995 |
|
Skin Neoplasms
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Amyloid aggregates of mutant p53 have been detected in breast cancer and malignant skin tumors.
|
24509441 |
2015 |
|
Skin Neoplasms
|
0.700 |
GeneticVariation
|
group |
BEFREE |
While hot spots for p53 mutations in human nonmelanoma skin tumors correspond quite well to slow spots for CPD repair in cultured cells irradiated with the model mutagen 254 nm UVC (which is not present in terrestrial sunlight), they do not all coincide with sequences that are initially frequently damaged by 254 nm UVC.
|
9383997 |
1997 |
|
Skin Neoplasms
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Here, we show, using conditional mouse technology, that epithelium-specific heterozygous expression of mutant p53 (i.e., the p53.R270H mutation that is equivalent to the human hotspot R273H) results in an increased incidence of spontaneous and UVB-induced skin tumors.
|
17510390 |
2007 |
|
Skin Neoplasms
|
0.700 |
GeneticVariation
|
group |
LHGDN |
Relationship between p53 codon 72 polymorphism and susceptibility to sunburn and skin cancer.
|
12164929 |
2002 |
|
Skin Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
Comparable p53 immunoreactivity was seen in skin tumors from both transplant and nontransplant patients.
|
8176007 |
1994 |
|
Skin Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
All p53 protein positive biopsies were from advanced lesions (cutaneous tumors or extracutaneous sites); none of 12 patch/plaque stage CTCL biopsies demonstrated p53 staining.
|
9579543 |
1998 |
|
Skin Neoplasms
|
0.700 |
GeneticVariation
|
group |
BEFREE |
In conclusion, molecular analysis using a combination of p53 and INK4a-ARF mutation analysis can identify the corresponding primary skin tumor in case of CSCC metastases in the majority of cases.
|
15613867 |
2005 |
|
Skin Neoplasms
|
0.700 |
GeneticVariation
|
group |
BEFREE |
This hypothesis was supported by the strict correlation observed between TP53 mutation and CK19 expression in a set of human skin tumors.
|
7515894 |
1994 |
|
Skin Neoplasms
|
0.700 |
GeneticVariation
|
group |
BEFREE |
This is in contrast to the UVB-induced skin tumors of normal mice, in which 92% of p53 mutations occurred as a result of DNA damage on the nontranscribed strand, and clear hot spots were observed.
|
9485015 |
1998 |
|
Skin Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
A comparison of sunlight-induced mutational spectra of the cII and lacI transgenes, as well as the p53 gene in skin tumors, shows that 5-methylcytosine is involved in 25 to 40 % of all mutations in all three systems.
|
11152598 |
2001 |
|
Skin Neoplasms
|
0.700 |
GeneticVariation
|
group |
BEFREE |
UV-A and UV-B caused similar numbers of p53 gene mutations in both benign and malignant human skin tumors, with UV-B-induced mutations being restricted to the upper areas of the tumors and UV-A-induced mutations predominating at the basal layer.
|
15335275 |
2005 |