TP53, tumor protein p53, 7157

N. diseases: 2494; N. variants: 527
Disease: Skin Neoplasms ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1042522
rs1042522
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0037286
Disease:
Skin Neoplasms 		0.010 GeneticVariation BEFREE Subjects carrying allele C of rs1042522 were associated with an increased risk of occupational skin neoplasms [<i>P</i>=0.027, odds ratio (OR)=1.97, 95% confidence intervals (CI) 1.08-3.63]. 29167767 2017
dbSNP: rs28934576
rs28934576
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0037286
Disease:
Skin Neoplasms 		0.010 GeneticVariation BEFREE Here, we show, using conditional mouse technology, that epithelium-specific heterozygous expression of mutant p53 (i.e., the p53.R270H mutation that is equivalent to the human hotspot R273H) results in an increased incidence of spontaneous and UVB-induced skin tumors. 17510390 2007