|
Skin Neoplasms
|
0.700 |
Biomarker
|
group |
CTD_mouse |
Whole-Exome Sequencing Validates a Preclinical Mouse Model for the Prevention and Treatment of Cutaneous Squamous Cell Carcinoma.
|
27923803 |
2017 |
|
Skin Neoplasms
|
0.700 |
GeneticVariation
|
group |
BEFREE |
PhIP-induced skin tumors were subjected to mutation screening, which identified genetic changes in Hras (7/40, 17.5%) and Tp53 (2/40, 5%), but not in Ctnnb1, a commonly mutated gene in PhIP-induced colon tumors.
|
28218467 |
2017 |
|
Skin Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
The authors identified genes demonstrating higher mutation frequencies in metastatic cSCC compared with primary tumors, including the chromatin remodeling gene lysine methyltransferase 2D (KMT2D) and the classic skin tumor suppressor tumor protein p53 (TP53), which was found to be mutated in 54% of primary tumors compared with 85% of metastatic tumors (P<.0001).
|
27906449 |
2017 |
|
Skin Neoplasms
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Amyloid aggregates of mutant p53 have been detected in breast cancer and malignant skin tumors.
|
24509441 |
2015 |
|
Skin Neoplasms
|
0.700 |
GeneticVariation
|
group |
BEFREE |
In one patient, molecular analyses demonstrated that skin tumor cells had the donor genotype and harbored a TP53 mutation in codon 175.
|
23979160 |
2013 |
|
Skin Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
Overexpression of Aurora-A and dysfunctional p53 may act synergistically to trigger skin tumor formation.
|
23174854 |
2013 |
|
Skin Neoplasms
|
0.700 |
Biomarker
|
group |
CTD_mouse |
Manganese superoxide dismutase is a p53-regulated gene that switches cancers between early and advanced stages.
|
22009531 |
2011 |
|
Skin Neoplasms
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Our studies have demonstrated that UV-induced mouse skin cancers contain p53 mutations at a high frequency and that these mutations can be detected in UV-irradiated mouse skin well before the appearance of skin tumors.
|
18173701 |
2008 |
|
Skin Neoplasms
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Microscopic clusters of cells overexpressing p53 with UVB signature mutations ("p53 patches") can be detected in the interfollicular epidermis long before the skin tumors arise.
|
18221455 |
2008 |
|
Skin Neoplasms
|
0.700 |
Biomarker
|
group |
LHGDN |
A darker side to p53.
|
17516921 |
2007 |
|
Skin Neoplasms
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Here, we show, using conditional mouse technology, that epithelium-specific heterozygous expression of mutant p53 (i.e., the p53.R270H mutation that is equivalent to the human hotspot R273H) results in an increased incidence of spontaneous and UVB-induced skin tumors.
|
17510390 |
2007 |
|
Skin Neoplasms
|
0.700 |
GeneticVariation
|
group |
BEFREE |
In conclusion, molecular analysis using a combination of p53 and INK4a-ARF mutation analysis can identify the corresponding primary skin tumor in case of CSCC metastases in the majority of cases.
|
15613867 |
2005 |
|
Skin Neoplasms
|
0.700 |
GeneticVariation
|
group |
BEFREE |
UV-A and UV-B caused similar numbers of p53 gene mutations in both benign and malignant human skin tumors, with UV-B-induced mutations being restricted to the upper areas of the tumors and UV-A-induced mutations predominating at the basal layer.
|
15335275 |
2005 |
|
Skin Neoplasms
|
0.700 |
GeneticVariation
|
group |
BEFREE |
The p53 tumour suppressor gene, which plays a pivotal role in cell division and apoptosis, is frequently found mutated in sunlight-induced skin tumours.
|
15752287 |
2005 |
|
Skin Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
The high level of ras oncogene activation, Ink4a-Arf and p53 tumor suppressor gene modifications as well as alterations of the different partners of the mitogenic sonic hedgehog signaling pathway (patched, smoothened and sonic hedgehog), characterized in XP skin tumors have clearly demonstrated the major role of the UV component of sunlight in the development of skin tumors.
|
15748637 |
2005 |
|
Skin Neoplasms
|
0.700 |
GeneticVariation
|
group |
BEFREE |
A comparison with previously obtained data on TP53 mutations from the same tumours showed closer concordance amongst mucosal than amongst skin tumours.
|
15457096 |
2004 |
|
Skin Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
Moreover, p53.S389A mice show increased sensitivity to UV-induced skin tumor development, signifying the importance of serine 389 phosphorylation for the tumor-suppressive function of p53.
|
15456863 |
2004 |
|
Skin Neoplasms
|
0.700 |
GeneticVariation
|
group |
LHGDN |
p53 mutations are common in human papillomavirus type 38-positive non-melanoma skin cancers.
|
15145527 |
2004 |
|
Skin Neoplasms
|
0.700 |
Biomarker
|
group |
CTD_human |
Genetic polymorphism in p53 codon 72 and skin cancer in southwestern Taiwan.
|
12635827 |
2003 |
|
Skin Neoplasms
|
0.700 |
GeneticVariation
|
group |
LHGDN |
Relationship between p53 codon 72 polymorphism and susceptibility to sunburn and skin cancer.
|
12164929 |
2002 |
|
Skin Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
A comparison of sunlight-induced mutational spectra of the cII and lacI transgenes, as well as the p53 gene in skin tumors, shows that 5-methylcytosine is involved in 25 to 40 % of all mutations in all three systems.
|
11152598 |
2001 |
|
Skin Neoplasms
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Molecular analysis of p53 and patched (PTCH), two candidate tumor suppressor genes for non-melanocytic skin cancer, was performed in skin tumors from six patients affected by the cancer-prone disease xeroderma pigmentosum (XP).
|
10656695 |
2000 |
|
Skin Neoplasms
|
0.700 |
GeneticVariation
|
group |
BEFREE |
The p53 codon 72Arginine allele does not confer susceptibility to the development of skin tumors after renal transplantation.
|
10755564 |
2000 |
|
Skin Neoplasms
|
0.700 |
GeneticVariation
|
group |
BEFREE |
The data indicate that dipyrimidines that contain 5-methylcytosine are preferential targets for sunlight-induced mutagenesis in cultured mammalian cells, thus explaining the large proportion of p53 mutations at such sites in skin tumors in vivo.
|
10543945 |
1999 |
|
Skin Neoplasms
|
0.700 |
Biomarker
|
group |
BEFREE |
All p53 protein positive biopsies were from advanced lesions (cutaneous tumors or extracutaneous sites); none of 12 patch/plaque stage CTCL biopsies demonstrated p53 staining.
|
9579543 |
1998 |