Carcinoma, Ovarian Epithelial
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We used CRISPR-DS to deeply sequence (mean Duplex depth ~3000×) the TP53 gene in 30 Pap tests from 21 women without cancer and 9 women with serous ovarian carcinoma with known TP53 driver mutations.
|
31839337 |
2020 |
Carcinoma, Ovarian Epithelial
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This study provides evidence that individual TP53 hotspot mutations have different impact on HGSOC patient outcomes and potentially TP53 function.
|
31780779 |
2020 |
Carcinoma, Ovarian Epithelial
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Improvements in mutational profiling have provided valuable insight, such as the ubiquity of TP53 mutations in HGSOC tumors.
|
31187121 |
2019 |
Carcinoma, Ovarian Epithelial
|
0.500 |
Biomarker
|
disease |
BEFREE |
Recently, this category of ovarian carcinoma has gained increasing attention owing to the recognition of morphological varieties of TP53-mutated high-grade ovarian carcinoma.
|
30636633 |
2019 |
Carcinoma, Ovarian Epithelial
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Targeting HDAC4, HIF-1α and CREBZF may be considered in treatment of ovarian cancer with p53 and RAS mutations.
|
30867818 |
2019 |
Carcinoma, Ovarian Epithelial
|
0.500 |
Biomarker
|
disease |
BEFREE |
We performed genome-wide copy number aberration (CNA) profiles and mutation hotspot screening (KRAS, BRAF, NRAS, ERBB2, PIK3CA, TP53) in 38 LGSOC tumor samples.
|
31054497 |
2019 |
Carcinoma, Ovarian Epithelial
|
0.500 |
Biomarker
|
disease |
BEFREE |
Prospective study of the efficacy and utility of TP53 mutations in circulating tumor DNA as a non-invasive biomarker of treatment response monitoring in patients with high-grade serous ovarian carcinoma.
|
30887755 |
2019 |
Carcinoma, Ovarian Epithelial
|
0.500 |
Biomarker
|
disease |
BEFREE |
Using cell lines representative of P53 wild-type ovarian cancer (A2780), and P53 mutant ovarian cancer (SKOV3), cells were implanted in the flank of athymic nude female mice.
|
31827119 |
2019 |
Carcinoma, Ovarian Epithelial
|
0.500 |
Biomarker
|
disease |
BEFREE |
Targeted Genomic Sequencing Reveals Novel <i>TP53</i> In-frame Deletion Mutations Leading to p53 Overexpression in High-grade Serous Tubo-ovarian Carcinoma.
|
31177126 |
2019 |
Carcinoma, Ovarian Epithelial
|
0.500 |
Biomarker
|
disease |
BEFREE |
Collectively, the present study suggested that CALB1 may act as an oncogene in ovarian cancer by inhibiting the p53 pathway.
|
31059057 |
2019 |
Carcinoma, Ovarian Epithelial
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Resistance to chemotherapy and high heterogeneity in mutations contribute to ovarian cancer's lethality, including many mutations in tumor suppressor p53.
|
31039796 |
2019 |
Carcinoma, Ovarian Epithelial
|
0.500 |
Biomarker
|
disease |
BEFREE |
Apparent Diffusion Coefficient Histogram Analysis for Assessing Tumor Staging and Detection of Lymph Node Metastasis in Epithelial Ovarian Cancer: Correlation with p53 and Ki-67 Expression.
|
30456593 |
2019 |
Carcinoma, Ovarian Epithelial
|
0.500 |
Biomarker
|
disease |
BEFREE |
High expression of the three transketolase genes was associated with unfavorable PFS in patients with TP53-mutated ovarian cancer, but not in patients with TP53 wild-type ovarian cancer.
|
31611995 |
2019 |
Carcinoma, Ovarian Epithelial
|
0.500 |
Biomarker
|
disease |
BEFREE |
CA125 and p53 are reliable markers that are useful for differentiating both uterine serous and ovarian serous carcinoma from their most common subtypes (endometrioid type carcinoma of ovary and uterus) but so far there is no histopathologic marker that differentiates USC from OSC.
|
31165997 |
2019 |
Carcinoma, Ovarian Epithelial
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Because chemokine network is involved in OC progression, we evaluated associations between chemokine expression and survival in tumor suppressor protein p53 (<i>TP53</i>) wild-type (<i>TP53</i>WT) and mutant (<i>TP53</i>m) OC datasets.
|
30181917 |
2018 |
Carcinoma, Ovarian Epithelial
|
0.500 |
Biomarker
|
disease |
BEFREE |
With lead times ≤6 months, ovarian cancer detection sensitivity at 0.98 specificity (SE98) varied from 0.19 [95% CI 0.08-0.40] for CTAG1A, CTAG2 and NUDT1 to 0.23 [0.10-0.44] for P53 (0.33 [0.11-0.68] for high-grade serous tumors).
|
29473162 |
2018 |
Carcinoma, Ovarian Epithelial
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Downregulation of AGR2, p21, and cyclin D and alterations in p53 function were associated with tumor progression and chemotherapy resistance in epithelial ovarian carcinoma.
|
29845750 |
2018 |
Carcinoma, Ovarian Epithelial
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Knowing that p53 expression status is used for chemotherapeutic approaches and prognosis in ovarian cancer, the results obtained highlight the importance of locating TP53 mutations.
|
29422776 |
2018 |
Carcinoma, Ovarian Epithelial
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
The icaritin-induced OC cell apoptosis may be associated with the activation of p53 and the suppression of Akt/mTOR pathway.
|
29625193 |
2018 |
Carcinoma, Ovarian Epithelial
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We analyzed mRNA expression of <i>PD-1</i>, <i>PD-L1</i> and <i>IFNG</i> by quantitative real-time PCR in tissue of 170 patients with low grade-serous (LGSOC), high-grade serous (HGSOC), endometrioid and clear cell OC compared to 28 non-diseased tissues (ovaries and fallopian tubes) in relation to tumor protein 53 (<i>TP53</i>) and breast cancer gene 1/2 (<i>BRCA1/2</i>) mutation status.
|
29707124 |
2018 |
Carcinoma, Ovarian Epithelial
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Cell adhesion molecule profiles, proliferation activity and p53 expression in advanced epithelial ovarian cancer induced malignant ascites-Correlation of tissue microarray and cytology microarray.
|
29801775 |
2018 |
Carcinoma, Ovarian Epithelial
|
0.500 |
Biomarker
|
disease |
BEFREE |
TP53 pathway may play pivotal roles in the development of ovarian cancer and TP53 pathway may be a new target for the treatment of ovarian cancer.
|
29565482 |
2018 |
Carcinoma, Ovarian Epithelial
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Role of Survivin and p53 Expression in Response of Primary Culture of Ovarian Cancer Cells to Treatment With Chemotherapeutic Agents.
|
29727353 |
2018 |
Carcinoma, Ovarian Epithelial
|
0.500 |
PosttranslationalModification
|
disease |
BEFREE |
The association between p53 protein phosphorylation at serine 15, serine 20 and sensitivity of cells isolated from patients with ovarian cancer and cell lines to chemotherapy in in vitro study.
|
29684847 |
2018 |
Carcinoma, Ovarian Epithelial
|
0.500 |
Biomarker
|
disease |
BEFREE |
In the present study we extended these studies to identify the molecular pathways regulated by QC to promote apoptosis independent of p53 status in OC.
|
29410485 |
2018 |