TP53, tumor protein p53, 7157

N. diseases: 2494; N. variants: 527
Disease: Carcinoma, Ovarian Epithelial ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1042522
rs1042522
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C4721610
Disease:
Carcinoma, Ovarian Epithelial 		0.040 GeneticVariation BEFREE Cumulative risk analysis revealed 3 unfavorable variants that increased significantly the risk of developing ovarian cancer (p.Ile1145 = ABCB1+ p.Asp1853Asn ATM+ p.Ser406Ala ATP7B- OR 7,47; p = 0,002) and significantly modified the progression free survival (PFS) of the patients, and also two favorable genotypes which protected against ovarian cancer (p.Arg952Lys ATP7B+ p.Arg72Pro TP53- OR 0,50; p = 0,008). 25591549 2015
dbSNP: rs1042522
rs1042522
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C4721610
Disease:
Carcinoma, Ovarian Epithelial 		0.040 GeneticVariation BEFREE The rs1042522 polymorphism was not overall associated with o</span>varian cancer risk. 25060098 2014
dbSNP: rs1042522
rs1042522
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C4721610
Disease:
Carcinoma, Ovarian Epithelial 		0.040 GeneticVariation BEFREE In conclusion SNPs in WRAP53 (rs2287497 and rs2287498) have stronger association with an ovarian cancer risk than rs1042522 in TP53. 23192612 2013
dbSNP: rs1042522
rs1042522
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C4721610
Disease:
Carcinoma, Ovarian Epithelial 		0.040 GeneticVariation BEFREE Meta-analysis shows significant association of the TP53 Arg72Pro with ovarian cancer risk. 21952824 2012
dbSNP: rs1131691014
rs1131691014
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C4721610
Disease:
Carcinoma, Ovarian Epithelial 		0.020 GeneticVariation BEFREE Cumulative risk analysis revealed 3 unfavorable variants that increased significantly the risk of developing ovarian cancer (p.Ile1145 = ABCB1+ p.Asp1853Asn ATM+ p.Ser406Ala ATP7B- OR 7,47; p = 0,002) and significantly modified the progression free survival (PFS) of the patients, and also two favorable genotypes which protected against ovarian cancer (p.Arg952Lys ATP7B+ p.Arg72Pro TP53- OR 0,50; p = 0,008). 25591549 2015
dbSNP: rs878854066
rs878854066
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C4721610
Disease:
Carcinoma, Ovarian Epithelial 		0.020 GeneticVariation BEFREE Cumulative risk analysis revealed 3 unfavorable variants that increased significantly the risk of developing ovarian cancer (p.Ile1145 = ABCB1+ p.Asp1853Asn ATM+ p.Ser406Ala ATP7B- OR 7,47; p = 0,002) and significantly modified the progression free survival (PFS) of the patients, and also two favorable genotypes which protected against ovarian cancer (p.Arg952Lys ATP7B+ p.Arg72Pro TP53- OR 0,50; p = 0,008). 25591549 2015
dbSNP: rs1131691014
rs1131691014
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C4721610
Disease:
Carcinoma, Ovarian Epithelial 		0.020 GeneticVariation BEFREE Meta-analysis shows significant association of the TP53 Arg72Pro with ovarian cancer risk. 21952824 2012
dbSNP: rs878854066
rs878854066
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C4721610
Disease:
Carcinoma, Ovarian Epithelial 		0.020 GeneticVariation BEFREE Meta-analysis shows significant association of the TP53 Arg72Pro with ovarian cancer risk. 21952824 2012
dbSNP: rs876660754
rs876660754
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C4721610
Disease:
Carcinoma, Ovarian Epithelial 		0.010 GeneticVariation BEFREE A direct sequencing analysis of p53 revealed a p.V173M mutation in exon 5 in both the breast tumor and the ovarian cancer. 28662703 2017
dbSNP: rs2287497
rs2287497
Entrez Id: 7157;55135
Gene Symbol: TP53;WRAP53
TP53;WRAP53
CUI: C4721610
Disease:
Carcinoma, Ovarian Epithelial 		0.010 GeneticVariation BEFREE In conclusion SNPs in WRAP53 (rs2287497 and rs2287498) have stronger association with an ovarian cancer risk than rs1042522 in TP53. 23192612 2013
dbSNP: rs2287498
rs2287498
Entrez Id: 7157;55135
Gene Symbol: TP53;WRAP53
TP53;WRAP53
CUI: C4721610
Disease:
Carcinoma, Ovarian Epithelial 		0.010 GeneticVariation BEFREE In conclusion SNPs in WRAP53 (rs2287497 and rs2287498) have stronger association with an ovarian cancer risk than rs1042522 in TP53. 23192612 2013
dbSNP: rs121913343
rs121913343
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C4721610
Disease:
Carcinoma, Ovarian Epithelial 		0.010 GeneticVariation BEFREE We present the apparent BRCA1-related, although mutation negative, breast and ovarian cancer patient who subsequently was confirmed to be TP53 c.817C>T (p.R273C) mutation carrier and discuss the importance of peri-diagnostic oncogenetic TP53 testing in early breast cancer cases. 21535297 2011
dbSNP: rs397516436
rs397516436
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C4721610
Disease:
Carcinoma, Ovarian Epithelial 		0.010 GeneticVariation BEFREE High prevalence of codon 213Arg-->Stop mutations of the TP53 gene in human ovarian cancer in the southwestern part of The Netherlands. 9579562 1998