|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Single-strand conformation polymorphism and heteroduplex analysis of the coding region of the UCP1 gene was performed in 56 subjects randomly selected at the draft board examination from a cohort of 156 males with juvenile-onset obesity.
|
9398715 |
1997 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
We now report the discovery of a gene that codes for a novel uncoupling protein, designated UCP2, which has 59% amino-acid identity to UCP1, and describe properties consistent with a role in diabetes and obesity.
|
9054939 |
1997 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
To study associations of UCP gene expression with human obesity, we determined, by a competitive reverse transcription-polymerase chain reaction assay, UCP mRNA expression levels in intra- and extraperitoneal adipose tissues of 79 obese subjects and 17 lean controls.
|
9374134 |
1997 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Human UCP3 is different from UCP1 and UCP2 by its high and preferential expression in skeletal muscle and consequently the UCP3 gene is an attractive candidate gene for obesity.
|
9498661 |
1998 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Uncoupling protein-1 mRNA expression in obese human subjects: the role of sequence variations at the uncoupling protein-1 gene locus.
|
9555947 |
1998 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
It was the aim of this study to examine the allelic frequency and the prevalence of the three UCP-1 genotypes in a broad caucasian cohort and to investigate the significance of this polymorphism for obesity and diabetes.
|
10469165 |
1999 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Some of these genes may promote obesity by gene-gene interactions (for example beta 3-adrenoceptors and uncoupling protein-1) or gene-environment interactions (for example beta 2-adrenoceptors and physical activity).
|
10889786 |
2000 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
The human uncoupling protein-1 gene (UCP1): present status and perspectives in obesity research.
|
12119988 |
2000 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the present study failed to demonstrate an additive or synergistic effect of the Trp/Arg64 variant of the BAR gene and the -3826 A-->G variant of the UCP1 gene on the development of obesity and insulin resistance among randomly recruited Danish Caucasian subjects.
|
10999801 |
2000 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
In overweight Australian women the -3826 G variant of UCP-1 increased the susceptibility to obesity indicating that UCP-1 could be involved in weight regulation.
|
10753048 |
2000 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
UCP1 expression is positively correlated with metabolic inefficiency, being increased by cold acclimation (in adults or perinatally) and overfeeding, and reduced in fasting and genetic obesity.
|
11239487 |
2001 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We suggest a role for UCP-1 polymorphism in the pathogenesis of obesity and arteriosclerosis.
|
11341297 |
2001 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Like its close relatives UCP1 and UCP3, UCP2 uncouples proton entry in the mitochondrial matrix from ATP synthesis and is therefore a candidate gene for obesity.
|
11381268 |
2001 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
The contribution of UCP genes towards polygenic obesity and Type II diabetes is evaluated and discussed.
|
11484071 |
2001 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Expression of UCP1 from the adipose-specific promoter in the aP2-Ucp1 transgenic mice mitigated obesity induced by genetic or dietary factors.
|
12079839 |
2002 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
A common Bcl I polymorphism in the promoter region of the UCP-1 gene is associated with reduced UCP-1 adipose tissue mRNA and obesity.
|
12029453 |
2002 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Correlation of the -3826A >G polymorphism in the promoter of the uncoupling protein 1 gene with obesity and metabolic disorders in obese families from southern Poland.
|
12375583 |
2002 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
We examined the expression of PGC-1, PPAR gamma, insulin receptor substrate-1 (IRS-1), glucose transporter isoform-4 (GLUT-4), and mitochondrial uncoupling protein-1 (UCP-1) in adipose tissue and skeletal muscle from non-obese, non-diabetic insulin-resistant, and insulin-sensitive individuals.
|
12565902 |
2003 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, we provide evidence that the role of Cidea in regulating thermogenesis, lipolysis and obesity may be mediated in part through its direct suppression of Ucp1 activity.
|
12910269 |
2003 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, central obesity in whites as reflected by an increased waist-to-hip ratio is associated with the UCP-1 Ala64Thr and UCP-3 C-55T polymorphisms.
|
12756473 |
2003 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, our results agree with the previously reported association between UCP1 -3826G allele and obesity and point to a gender-related effect.
|
15536594 |
2004 |
|
Obesity
|
0.400 |
Therapeutic
|
disease |
CTD_human |
Ectopic expression of mitochondrial uncoupling protein 1 (UCP1) in the white adipose tissue of the aP2-Ucp1 transgenic mice reduced obesity induced by genetic or dietary manipulations.
|
15592485 |
2004 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Uncoupling protein-1 (UCP-1) plays a major role in thermogenesis, and has been implicated in the pathogenesis of obesity and metabolic disorders.
|
15281018 |
2004 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The effects of UCP-1 polymorphisms on obesity phenotypes among Korean female subjects.
|
16084837 |
2005 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our findings provide evidence that UCP1 is neither essential for body weight regulation nor for longevity under conditions of standard diet and normal housing temperature, but deficiency increases susceptibility to obesity with age in combination with HF diet.
|
15924571 |
2005 |