|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The stimulation of NRF-1, TFam, UCP-1 and the enhanced activity of mitochondrial complex IV may be associated with remedying obesity.
|
17397829 |
2007 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A-3826G polymorphism within the promoter region of the uncoupling protein-1 (UCP-1) gene is possibly involved in the pathophysiology of obesity and metabolic disorders.
|
18068010 |
2008 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Several obesity- and nutrient-related gene polymorphisms but not FTO and UCP variants modulate postabsorptive resting energy expenditure and fat-induced thermogenesis in obese individuals: the NUGENOB study.
|
19399022 |
2009 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Mice lacking UCP1 are cold sensitive, but surprisingly not obese at room temperature.
|
19187768 |
2009 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We conclude that ambient temperature is qualitatively determinative for the outcome of metabolic studies, that no other protein and no other mechanism can substitute for UCP1 in mediating diet-induced adrenergic thermogenesis, and that UCP1 activity can be determinative for obesity development in mice and possibly in humans.
|
19187776 |
2009 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
This review summarizes data supporting the existence of brown adipocytes and the role of UCP1 in energy dissipation in adult humans, and the genetic variety association with the fat metabolism, obesity and diabetes.
|
19444646 |
2010 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The uncoupling protein (UCP) gene is one of the genes known to have a strong association with obesity and insulin resistance.
|
21584501 |
2011 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Although each polymorphism of β3AR Trp64Arg, β2AR Arg16Gly and UCP1 -3826A>G is known to be associated with obesity, the interaction among these polymorphisms is not fully understood.
|
21959333 |
2011 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This study links the GG homozygous form of UCP1 with obesity and blood pressure among females only.
|
22764640 |
2012 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our data are consistent with FTO rs9939609 and UCP-1 rs6536991 common variants as contributors to obesity in the Brazilian population.
|
23134754 |
2012 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to test the predictive value of presence/absence of polymorphisms/ variants in β3-adrenergic receptor (ADRB3), uncoupling protein 1 (UCP1), peroxisome proliferator-activated receptor γ (PPARγ), and adiponectin (ADIPOQ) genes in diagnosing the IR in obesity.
|
22391136 |
2012 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
The role of the uncoupling protein 1 (UCP1) on the development of obesity and type 2 diabetes mellitus.
|
22790465 |
2012 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Uncoupling protein-1 (UCP-1), which plays a major role in thermogenesis and energy expenditure can increase the risk of obesity and can be related metabolic disorders.
|
23043591 |
2012 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Activation of the cold-sensing TRPM8 channel triggers UCP1-dependent thermogenesis and prevents obesity.
|
22241835 |
2012 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Uncoupling protein (UCP) genes, which may contribute to energy metabolism in mitochondria, may be involved in the pathogenesis of obesity.
|
23412863 |
2013 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in uncoupling protein (UCP) genes have been strongly associated with energy expenditure and obesity.
|
23101559 |
2013 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Reduced UCP-1 content in in vitro differentiated beige/brite adipocytes derived from preadipocytes of human subcutaneous white adipose tissues in obesity.
|
24642703 |
2014 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The seasonal increase in abdominal SC WAT UCP1 mRNA was considerably diminished in subjects with a BMI > 30 kg/m(2), suggesting that dysfunctional WAT in obesity inhibits adipose thermogenesis.
|
25299843 |
2014 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
JZ expression of thyroid hormone signaling components Trh, Dio2, Trα, and Ucp2 were negatively associated with maternal leptin. mRNA expression of TRH, TRβ and UCP1 were also decreased in term placenta from OB women.
|
25449029 |
2014 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In our case-control study we were not able to demonstrate any association between UCP polymorphisms and obesity in T2DM patients; however, in the meta-analysis we detected a significant association of UCP2 -866G/A, Ins/Del, Ala55Val and UCP3 -55C/T polymorphisms with obesity.
|
24752406 |
2014 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
UCP1 -3826A/G and ADRB3 Trp64Arg polymorphisms may have a combined effect in the modulation of overweight/obesity and HDL-C levels in type 2 diabetes mellitus (T2DM) Caucasian-Brazilian patients.
|
24138564 |
2014 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Effect of Zingiber officinale Supplementation on Obesity Management with Respect to the Uncoupling Protein 1 -3826A>G and ß3-adrenergic Receptor Trp64Arg Polymorphism.
|
25899896 |
2015 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Post-transcriptional Stabilization of Ucp1 mRNA Protects Mice from Diet-Induced Obesity.
|
26711342 |
2015 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
The UCP1 or UCP3 SNPs were not associated with obesity/BMI and total body fat (TBF), but combinatory genotype analysis revealed that those having the AA and CC genotype for the former and latter SNPs had significantly highest BMI and TBF compared to other genotype combinations.
|
25812254 |
2015 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This study examined the possible association of the β3-AR and UCP1 polymorphisms with overweight/obesity or lipid variation in a Southwest Chinese population.
|
25928572 |
2015 |