|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
UCP1 expression is positively correlated with metabolic inefficiency, being increased by cold acclimation (in adults or perinatally) and overfeeding, and reduced in fasting and genetic obesity.
|
11239487 |
2001 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Uncoupling protein-1 (UCP-1) plays a major role in thermogenesis, and has been implicated in the pathogenesis of obesity and metabolic disorders.
|
15281018 |
2004 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Uncoupling protein-1 (UCP-1), which plays a major role in thermogenesis and energy expenditure can increase the risk of obesity and can be related metabolic disorders.
|
23043591 |
2012 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
UCP1 -3826A/G and ADRB3 Trp64Arg polymorphisms may have a combined effect in the modulation of overweight/obesity and HDL-C levels in type 2 diabetes mellitus (T2DM) Caucasian-Brazilian patients.
|
24138564 |
2014 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
UCP1 has re-gained researchers' attention in the context of obesity following the realization that BAT is present and can be activated in adult humans and of inducible UCP1-expressing cells in white fat depots.
|
28057582 |
2017 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
UCP1 is only expressed during brown fat cell differentiation and is a candidate target for treating obesity.
|
29796650 |
2018 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Ucp1 induction by stimuli including cold, exercise, and diet increases nonshivering thermogenesis, leading to increased energy expenditure and prevention of obesity.
|
30450758 |
2019 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Uncoupling protein 1 (UCP1) plays a key role in nonshivering thermogenesis and is involved in the pathogenesis of obesity.
|
31271850 |
2019 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Uncoupling protein-1 mRNA expression in obese human subjects: the role of sequence variations at the uncoupling protein-1 gene locus.
|
9555947 |
1998 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A-3826G polymorphism within the promoter region of the uncoupling protein-1 (UCP-1) gene is possibly involved in the pathophysiology of obesity and metabolic disorders.
|
18068010 |
2008 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
A common Bcl I polymorphism in the promoter region of the UCP-1 gene is associated with reduced UCP-1 adipose tissue mRNA and obesity.
|
12029453 |
2002 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A significant association of UCP1 polymorphisms rs3811791 was observed only in the moderate-obese cohort [OR = 2.89 (1.33-6.25); p = 0.007] but not in the extreme-obese cohort indicating an overlying genetic complexity between moderate-obesity and extreme-obesity.
|
30458724 |
2018 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Abbreviations: ALT, Alanine aminotransferase; AMPK, AMP-activated protein kinase; ATMs, Adipose tissue macrophages; BAT, Brown adipose tissue; CDDO-Im, 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid-imidazolide; CDDO-Me, CDDO-methyl ester; DIO, High-fat-diet-induced obese; FFA, Free fatty acid; FGF, Fibroblast growth factor; GTP, Glutamyl transpeptidase; HFD, High-fat diet; IKKβ, Inhibitor of κB-kinase β; IL, Interleukin; JNK, C-Jun N-terminal kinase; KD, Knockdown; Keap1, Kelch-like ECH-associated protein 1; KO, Knockout; LPS, Lipopolysaccharide; NADPH, Nicotinamide adenine dinucleotide phosphate; NAFLD, Non-alcoholic fatty liver disease; NF-κB, Nuclear factor-κB; Nrf2, Nuclear factor E2-related factor 2; ROS, Reactive oxygen species; T2D, Type 2 diabetes; TLR, Toll-like receptor; TNF, tumor necrosis factor; UCP, Uncoupling protein; WAT, White adipose tissue.
|
29898626 |
2018 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Activation of the cold-sensing TRPM8 channel triggers UCP1-dependent thermogenesis and prevents obesity.
|
22241835 |
2012 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Activation of thermogenesis in brown adipose tissue (BAT) and the ability to increase uncoupling protein 1 (UCP1) levels and mitochondrial biogenesis in white fat (termed 'browning'), has great therapeutic potential to treat obesity and its comorbidities because of the net increase in energy expenditure.
|
29396369 |
2018 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
All of these will guide us to design new UCP1 activators for the treatment of obesity and diabetes.
|
31264791 |
2019 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Although each polymorphism of β3AR Trp64Arg, β2AR Arg16Gly and UCP1 -3826A>G is known to be associated with obesity, the interaction among these polymorphisms is not fully understood.
|
21959333 |
2011 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
As UCP1-enriched cells can consume lipids by generating heat, browning of white adipocytes is now highlighted as a promising approach for the prevention of obesity and obesity-associated metabolic diseases.
|
30132867 |
2019 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Both, BAT Ucp1 and Pgc1α mRNA decreased significantly in response to obesity and physical activity.
|
30201103 |
2018 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Brown adipocytes dissipate energy through non-shivering thermogenesis mediated by UCP1 protein, hence representing a powerful target to overcome obesity due to energy surplus.
|
30367407 |
2019 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Brown adipose tissue (BAT) dissipates energy through Ucp1-mediated uncoupled respiration and its activation may represent a therapeutic strategy to combat obesity.
|
27461402 |
2016 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Brown adipose tissue (BAT) with its thermogenic function due to the presence of the mitochondrial uncoupling protein 1 (UCP1), has been positively associated with improved resistance to obesity and metabolic diseases.
|
30687113 |
2018 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Ccr7 null mice are protected against diet-induced obesity via Ucp1 upregulation and enhanced energy expenditure.
|
31312229 |
2019 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Consequently, targeted mitochondrial uncoupling in adipose tissue and skeletal muscle of UCP1-transgenic mice increased substrate metabolism and ameliorates obesity, hypertriglyceridemia and insulin resistance.
|
27916644 |
2017 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Correlation of the -3826A >G polymorphism in the promoter of the uncoupling protein 1 gene with obesity and metabolic disorders in obese families from southern Poland.
|
12375583 |
2002 |