|
Obesity
|
0.400 |
Therapeutic
|
disease |
CTD_human |
Ectopic expression of mitochondrial uncoupling protein 1 (UCP1) in the white adipose tissue of the aP2-Ucp1 transgenic mice reduced obesity induced by genetic or dietary manipulations.
|
15592485 |
2004 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Effect of Zingiber officinale Supplementation on Obesity Management with Respect to the Uncoupling Protein 1 -3826A>G and ß3-adrenergic Receptor Trp64Arg Polymorphism.
|
25899896 |
2015 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Expression of UCP1 from the adipose-specific promoter in the aP2-Ucp1 transgenic mice mitigated obesity induced by genetic or dietary factors.
|
12079839 |
2002 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, our results agree with the previously reported association between UCP1 -3826G allele and obesity and point to a gender-related effect.
|
15536594 |
2004 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, we provide evidence that the role of Cidea in regulating thermogenesis, lipolysis and obesity may be mediated in part through its direct suppression of Ucp1 activity.
|
12910269 |
2003 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Genetic or pharmacological inactivation of the integrin α<sub>4</sub> in mice resulted in elevated expression of UCP1 and beige adipogenesis of subcutaneous AT in obesity.
|
28414311 |
2017 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
High concentrations of both visfatin and leptin led to a dramatic decrease in UCP-1 protein levels, supporting the notion that visfatin levels are raised in obesity and that obese people have reduced BAT activity, plausibly through a reduction in UCP-1 levels.
|
30060995 |
2019 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
However, relying on UCP1-based thermogenesis alone may not be sufficient to control obesity in humans.
|
29086530 |
2017 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Human UCP3 is different from UCP1 and UCP2 by its high and preferential expression in skeletal muscle and consequently the UCP3 gene is an attractive candidate gene for obesity.
|
9498661 |
1998 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In addition to sympathetic nerve-derived NE, the intestinal microbiota was involved in the increase in NE.Infection with <i>H. polygyrus</i> altered the composition of intestinal bacteria, and antibiotic treatment to reduce intestinal bacteria reversed the higher NE concentration, UCP1 expression, and prevention of the weight gain observed after <i>H. polygyrus</i> infection.Our data indicate that <i>H. polygyrus</i> exerts suppressive roles on obesity through modulation of microbiota that produce NE.
|
30962398 |
2019 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, central obesity in whites as reflected by an increased waist-to-hip ratio is associated with the UCP-1 Ala64Thr and UCP-3 C-55T polymorphisms.
|
12756473 |
2003 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, DBT could stimulate phosphorylation of AMPK to raise expression of UCP1 and PGC-1α, and activate thermogenesis to prevent obesity.
|
30258363 |
2018 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the present study failed to demonstrate an additive or synergistic effect of the Trp/Arg64 variant of the BAR gene and the -3826 A-->G variant of the UCP1 gene on the development of obesity and insulin resistance among randomly recruited Danish Caucasian subjects.
|
10999801 |
2000 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
In each case, indices of BAT activity and capacity (mitochondrial content, GDP binding, amount of UCP1) indicated that the tissue plays a role in DIT and that obesity is characterised by reduced thermogenesis.
|
27621146 |
2017 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In mice, IFI202b overexpression caused obesity (Δ body weight at the age of 30 weeks: 10.2 ± 1.9 g vs wild-type mice) marked by hypertrophic fat mass expansion, increased expression of Zfp423 (encoding the transcription factor zinc finger protein [ZFP] 423) and white-selective genes (Tcf21, Tle3), and decreased expression of thermogenic genes (e.g.Cidea, Ucp1).
|
29478099 |
2018 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In our case-control study we were not able to demonstrate any association between UCP polymorphisms and obesity in T2DM patients; however, in the meta-analysis we detected a significant association of UCP2 -866G/A, Ins/Del, Ala55Val and UCP3 -55C/T polymorphisms with obesity.
|
24752406 |
2014 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
In overweight Australian women the -3826 G variant of UCP-1 increased the susceptibility to obesity indicating that UCP-1 could be involved in weight regulation.
|
10753048 |
2000 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In summary, our data suggest that allicin potentially prevents obesity and associated metabolic disorders such as type 2 diabetes mellitus by enhancing the expression of brown adipocyte-specific genes, including UCP-1, through KLF15 signal cascade.
|
30423518 |
2019 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
In three experiments of similar setup, uncoupling protein 1-ablated mice fed a high‑fat diet had either reduced or similar body mass gain, food intake and metabolic efficiency compared to wildtype mice, challenging the hypothesized role of this protein in the development of diet-induced obesity.
|
31714796 |
2020 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Intake of a high-fat diet rich in omega-3 fatty acids protects both wild-type and UCP1-deficient mice from obesity and insulin resistance by increasing energy expenditure through unknown mechanisms.
|
30632684 |
2019 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
It was the aim of this study to examine the allelic frequency and the prevalence of the three UCP-1 genotypes in a broad caucasian cohort and to investigate the significance of this polymorphism for obesity and diabetes.
|
10469165 |
1999 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
JZ expression of thyroid hormone signaling components Trh, Dio2, Trα, and Ucp2 were negatively associated with maternal leptin. mRNA expression of TRH, TRβ and UCP1 were also decreased in term placenta from OB women.
|
25449029 |
2014 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Like its close relatives UCP1 and UCP3, UCP2 uncouples proton entry in the mitochondrial matrix from ATP synthesis and is therefore a candidate gene for obesity.
|
11381268 |
2001 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Mechanistically, we found that mulberry leaves could alleviate obesity by enhancing brown adipose tissue (BAT) activity partly indicated by elevated thermogenesis and overexpression of uncoupling protein 1 in BAT.
|
31312821 |
2019 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Melinjo (Gnetum gnemon L.) seed extract induces uncoupling protein 1 expression in brown fat and protects mice against diet-induced obesity, inflammation, and insulin resistance.
|
30340811 |
2018 |