|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This study links the GG homozygous form of UCP1 with obesity and blood pressure among females only.
|
22764640 |
2012 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Single-strand conformation polymorphism and heteroduplex analysis of the coding region of the UCP1 gene was performed in 56 subjects randomly selected at the draft board examination from a cohort of 156 males with juvenile-onset obesity.
|
9398715 |
1997 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A significant association of UCP1 polymorphisms rs3811791 was observed only in the moderate-obese cohort [OR = 2.89 (1.33-6.25); p = 0.007] but not in the extreme-obese cohort indicating an overlying genetic complexity between moderate-obesity and extreme-obesity.
|
30458724 |
2018 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The uncoupling protein (UCP) gene is one of the genes known to have a strong association with obesity and insulin resistance.
|
21584501 |
2011 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
It was the aim of this study to examine the allelic frequency and the prevalence of the three UCP-1 genotypes in a broad caucasian cohort and to investigate the significance of this polymorphism for obesity and diabetes.
|
10469165 |
1999 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Effect of Zingiber officinale Supplementation on Obesity Management with Respect to the Uncoupling Protein 1 -3826A>G and ß3-adrenergic Receptor Trp64Arg Polymorphism.
|
25899896 |
2015 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, our results agree with the previously reported association between UCP1 -3826G allele and obesity and point to a gender-related effect.
|
15536594 |
2004 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Several obesity- and nutrient-related gene polymorphisms but not FTO and UCP variants modulate postabsorptive resting energy expenditure and fat-induced thermogenesis in obese individuals: the NUGENOB study.
|
19399022 |
2009 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our data are consistent with FTO rs9939609 and UCP-1 rs6536991 common variants as contributors to obesity in the Brazilian population.
|
23134754 |
2012 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in uncoupling protein (UCP) genes have been strongly associated with energy expenditure and obesity.
|
23101559 |
2013 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Therefore, several studies investigating the role of polymorphisms in the gene encoding UCP1 in susceptibility to obesity or metabolic syndrome have been performed.
|
28100847 |
2016 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The effects of UCP-1 polymorphisms on obesity phenotypes among Korean female subjects.
|
16084837 |
2005 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We suggest a role for UCP-1 polymorphism in the pathogenesis of obesity and arteriosclerosis.
|
11341297 |
2001 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In our case-control study we were not able to demonstrate any association between UCP polymorphisms and obesity in T2DM patients; however, in the meta-analysis we detected a significant association of UCP2 -866G/A, Ins/Del, Ala55Val and UCP3 -55C/T polymorphisms with obesity.
|
24752406 |
2014 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We investigated whether or not the UCP1 -3826 A>G polymorphism is associated with obesity and related metabolic disorders in grade III obese patients.
|
26458326 |
2016 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Correlation of the -3826A >G polymorphism in the promoter of the uncoupling protein 1 gene with obesity and metabolic disorders in obese families from southern Poland.
|
12375583 |
2002 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
UCP1 -3826A/G and ADRB3 Trp64Arg polymorphisms may have a combined effect in the modulation of overweight/obesity and HDL-C levels in type 2 diabetes mellitus (T2DM) Caucasian-Brazilian patients.
|
24138564 |
2014 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This study examined the possible association of the β3-AR and UCP1 polymorphisms with overweight/obesity or lipid variation in a Southwest Chinese population.
|
25928572 |
2015 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the present study failed to demonstrate an additive or synergistic effect of the Trp/Arg64 variant of the BAR gene and the -3826 A-->G variant of the UCP1 gene on the development of obesity and insulin resistance among randomly recruited Danish Caucasian subjects.
|
10999801 |
2000 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Although each polymorphism of β3AR Trp64Arg, β2AR Arg16Gly and UCP1 -3826A>G is known to be associated with obesity, the interaction among these polymorphisms is not fully understood.
|
21959333 |
2011 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The GG genotype of UCP1, together with the del/del genotype of the UCP2 polymorphism, may increase the risk of obesity with synergistic effects.
|
28704105 |
2017 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A-3826G polymorphism within the promoter region of the uncoupling protein-1 (UCP-1) gene is possibly involved in the pathophysiology of obesity and metabolic disorders.
|
18068010 |
2008 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, central obesity in whites as reflected by an increased waist-to-hip ratio is associated with the UCP-1 Ala64Thr and UCP-3 C-55T polymorphisms.
|
12756473 |
2003 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Both the A-->C polymorphism and the Met229-->Leu polymorphism of UCP1 are in linkage disequilibrium and could be one of the diabetes associated single nucleotide polymorphisms (SNPs).
|
11317671 |
2001 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
It was the aim of this study to examine the allelic frequency and the prevalence of the three UCP-1 genotypes in a broad caucasian cohort and to investigate the significance of this polymorphism for obesity and diabetes.
|
10469165 |
1999 |