Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
In three experiments of similar setup, uncoupling protein 1-ablated mice fed a high‑fat diet had either reduced or similar body mass gain, food intake and metabolic efficiency compared to wildtype mice, challenging the hypothesized role of this protein in the development of diet-induced obesity.
|
31714796 |
2020 |
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In summary, our data suggest that allicin potentially prevents obesity and associated metabolic disorders such as type 2 diabetes mellitus by enhancing the expression of brown adipocyte-specific genes, including UCP-1, through KLF15 signal cascade.
|
30423518 |
2019 |
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
There were no significant differences in mRNA levels of uncoupling protein-1 or F4/80 in brown AT (BAT) or of several intestinal integrity markers in colon suggesting that the protection against obesity is not due to excessive BAT or to impaired intestinal absorption of fat.
|
30860940 |
2019 |
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Uncoupling protein 1 (UCP1) plays a key role in nonshivering thermogenesis and is involved in the pathogenesis of obesity.
|
31271850 |
2019 |
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
These results demonstrated that LFBE decreased obesity partly by increasing the BAT mass and the energy expenditure by activating BAT thermogenesis and WAT browning in a UCP1-dependent mechanism.
|
31488234 |
2019 |
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Brown adipocytes dissipate energy through non-shivering thermogenesis mediated by UCP1 protein, hence representing a powerful target to overcome obesity due to energy surplus.
|
30367407 |
2019 |
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
As UCP1-enriched cells can consume lipids by generating heat, browning of white adipocytes is now highlighted as a promising approach for the prevention of obesity and obesity-associated metabolic diseases.
|
30132867 |
2019 |
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thus, our results demonstrate that the development of glucocorticoid-induced obesity is not caused by a decreased UCP1-dependent thermogenic capacity.
|
31067456 |
2019 |
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
These processes were correlated with the increased gene expression of Dio2 and Ucp-1, which represents brown adipose tissue (BAT) activation, in both WD-induced atherosclerosis and high-fat-induced obesity models.
|
31570705 |
2019 |
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
To evaluate mitochondrial respiratory capacity, mitochondrial content, and UCP1 gene expression in white adipose tissue from women with obesity before and after the physical training program.
|
31282585 |
2019 |
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Ccr7 null mice are protected against diet-induced obesity via Ucp1 upregulation and enhanced energy expenditure.
|
31312229 |
2019 |
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
The absence of UCP1 augmented obesity (weight gain, body fat mass, %body fat, fat depot size) in high-fat diet- and cafeteria-fed mice, with a similar or lower food intake, indicating that, when present, UCP1 indeed decreases metabolic efficiency.
|
30807213 |
2019 |
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Intake of a high-fat diet rich in omega-3 fatty acids protects both wild-type and UCP1-deficient mice from obesity and insulin resistance by increasing energy expenditure through unknown mechanisms.
|
30632684 |
2019 |
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Ucp1 induction by stimuli including cold, exercise, and diet increases nonshivering thermogenesis, leading to increased energy expenditure and prevention of obesity.
|
30450758 |
2019 |
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In addition to sympathetic nerve-derived NE, the intestinal microbiota was involved in the increase in NE.Infection with <i>H. polygyrus</i> altered the composition of intestinal bacteria, and antibiotic treatment to reduce intestinal bacteria reversed the higher NE concentration, UCP1 expression, and prevention of the weight gain observed after <i>H. polygyrus</i> infection.Our data indicate that <i>H. polygyrus</i> exerts suppressive roles on obesity through modulation of microbiota that produce NE.
|
30962398 |
2019 |
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
All of these will guide us to design new UCP1 activators for the treatment of obesity and diabetes.
|
31264791 |
2019 |
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Our results clearly showed that <i>UCP1</i>-VAT expression was significantly increased in severe human obesity (BMI > 50 kg/m<sup>2</sup>) and that it behaved as an independent predictor of REE.
|
31440209 |
2019 |
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
This work provides evidences that BML-260 can also exert a JSP-1-independent effect in activating UCP1 and thermogenesis in adipocytes, and be potentially applied to treat obesity.
|
31281493 |
2019 |
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Mechanistically, we found that mulberry leaves could alleviate obesity by enhancing brown adipose tissue (BAT) activity partly indicated by elevated thermogenesis and overexpression of uncoupling protein 1 in BAT.
|
31312821 |
2019 |
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
High concentrations of both visfatin and leptin led to a dramatic decrease in UCP-1 protein levels, supporting the notion that visfatin levels are raised in obesity and that obese people have reduced BAT activity, plausibly through a reduction in UCP-1 levels.
|
30060995 |
2019 |
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Since UCP1 expends energy on thermogenesis, UCP1 activation has been considered an approach to ameliorate obesity.
|
31074834 |
2019 |
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
White adipose tissue (WAT) is the primary energy storage organ and its excess contributes to obesity, while brown adipose tissue (BAT) and inducible thermogenic (beige/brite) adipocytes in WAT dissipate energy via Ucp1 to maintain body temperature.
|
29704660 |
2019 |
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Oxyresveratrol Increases Energy Expenditure through Foxo3a-Mediated Ucp1 Induction in High-Fat-Diet-Induced Obese Mice.
|
30577593 |
2018 |
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A significant association of UCP1 polymorphisms rs3811791 was observed only in the moderate-obese cohort [OR = 2.89 (1.33-6.25); p = 0.007] but not in the extreme-obese cohort indicating an overlying genetic complexity between moderate-obesity and extreme-obesity.
|
30458724 |
2018 |
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Brown adipose tissue (BAT) with its thermogenic function due to the presence of the mitochondrial uncoupling protein 1 (UCP1), has been positively associated with improved resistance to obesity and metabolic diseases.
|
30687113 |
2018 |