UCP1, uncoupling protein 1, 7350

N. diseases: 124; N. variants: 7
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0028754
Disease: Obesity
Obesity 		0.400 GeneticVariation disease BEFREE Single-strand conformation polymorphism and heteroduplex analysis of the coding region of the UCP1 gene was performed in 56 subjects randomly selected at the draft board examination from a cohort of 156 males with juvenile-onset obesity. 9398715 1997
CUI: C0028754
Disease: Obesity
Obesity 		0.400 Biomarker disease BEFREE We now report the discovery of a gene that codes for a novel uncoupling protein, designated UCP2, which has 59% amino-acid identity to UCP1, and describe properties consistent with a role in diabetes and obesity. 9054939 1997
CUI: C0028754
Disease: Obesity
Obesity 		0.400 AlteredExpression disease BEFREE To study associations of UCP gene expression with human obesity, we determined, by a competitive reverse transcription-polymerase chain reaction assay, UCP mRNA expression levels in intra- and extraperitoneal adipose tissues of 79 obese subjects and 17 lean controls. 9374134 1997
CUI: C0011847
Disease: Diabetes
Diabetes 		0.100 Biomarker disease BEFREE We now report the discovery of a gene that codes for a novel uncoupling protein, designated UCP2, which has 59% amino-acid identity to UCP1, and describe properties consistent with a role in diabetes and obesity. 9054939 1997
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus 		0.100 Biomarker group BEFREE We now report the discovery of a gene that codes for a novel uncoupling protein, designated UCP2, which has 59% amino-acid identity to UCP1, and describe properties consistent with a role in diabetes and obesity. 9054939 1997
CUI: C0024299
Disease: Lymphoma
Lymphoma 		0.020 Biomarker group BEFREE The immunophenotypic profiles of UCP-L were confirmed to correspond to the presumptive lymphoma cell population by use of a live gating procedure on the large cells, which eliminated interference by reactive cells or necrotic tissue fragments. 9369423 1997
CUI: C1332206
Disease: Adult Lymphoma
Adult Lymphoma 		0.020 Biomarker disease BEFREE The immunophenotypic profiles of UCP-L were confirmed to correspond to the presumptive lymphoma cell population by use of a live gating procedure on the large cells, which eliminated interference by reactive cells or necrotic tissue fragments. 9369423 1997
CUI: C1332979
Disease: Childhood Lymphoma
Childhood Lymphoma 		0.020 Biomarker disease BEFREE The immunophenotypic profiles of UCP-L were confirmed to correspond to the presumptive lymphoma cell population by use of a live gating procedure on the large cells, which eliminated interference by reactive cells or necrotic tissue fragments. 9369423 1997
CUI: C0019829
Disease: Hodgkin Disease
Hodgkin Disease 		0.010 GeneticVariation disease BEFREE Using this method, we identified UCP-L in 208 of 293 (71%) consecutive cases of non-Hodgkin's lymphomas, while no UCP-L were seen in 72 cases of non-specific hyperplasia of lymph nodes. 9369423 1997
CUI: C0024305
Disease: Lymphoma, Non-Hodgkin
Lymphoma, Non-Hodgkin 		0.010 GeneticVariation disease BEFREE When those cases were eliminated from the analysis, 80% of non-Hodgkin's lymphoma were found to contain UCP-L. 9369423 1997
CUI: C0079772
Disease: T-Cell Lymphoma
T-Cell Lymphoma 		0.010 Biomarker disease BEFREE The common morphology of UCP-L as defined by forward and side scatter grams was consistent with a 'lymphoid appearance' except in several cases of HTLV-I-positive T cell lymphoma and gammadelta T cell lymphoma. 9369423 1997
CUI: C0220597
Disease: Adult Hodgkin Lymphoma
Adult Hodgkin Lymphoma 		0.010 Biomarker disease BEFREE Only one of 21 cases of Hodgkin's lymphoma was found to have UCP-L. 9369423 1997
CUI: C0220605
Disease: Adult Non-Hodgkin Lymphoma
Adult Non-Hodgkin Lymphoma 		0.010 GeneticVariation disease BEFREE When those cases were eliminated from the analysis, 80% of non-Hodgkin's lymphoma were found to contain UCP-L. 9369423 1997
CUI: C0220612
Disease: Childhood Non-Hodgkin Lymphoma
Childhood Non-Hodgkin Lymphoma 		0.010 GeneticVariation disease BEFREE When those cases were eliminated from the analysis, 80% of non-Hodgkin's lymphoma were found to contain UCP-L. 9369423 1997
CUI: C0220644
Disease: Childhood Hodgkin Lymphoma
Childhood Hodgkin Lymphoma 		0.010 Biomarker disease BEFREE Only one of 21 cases of Hodgkin's lymphoma was found to have UCP-L. 9369423 1997
CUI: C0694571
Disease: extranodal lymphoma
extranodal lymphoma 		0.010 Biomarker disease BEFREE In B cell lymphoma, the incidence of UCP-L in nodal lymphomas (80%) was much higher than in extranodal lymphomas (47%). 9369423 1997
CUI: C4721532
Disease: Lymphoma, Non-Hodgkin, Familial
Lymphoma, Non-Hodgkin, Familial 		0.010 GeneticVariation disease BEFREE When those cases were eliminated from the analysis, 80% of non-Hodgkin's lymphoma were found to contain UCP-L. 9369423 1997
CUI: C0028754
Disease: Obesity
Obesity 		0.400 AlteredExpression disease BEFREE Human UCP3 is different from UCP1 and UCP2 by its high and preferential expression in skeletal muscle and consequently the UCP3 gene is an attractive candidate gene for obesity. 9498661 1998
CUI: C0028754
Disease: Obesity
Obesity 		0.400 AlteredExpression disease BEFREE Uncoupling protein-1 mRNA expression in obese human subjects: the role of sequence variations at the uncoupling protein-1 gene locus. 9555947 1998
CUI: C0020474
Disease: Hyperlipidemia, Familial Combined
Hyperlipidemia, Familial Combined 		0.010 Biomarker disease BEFREE The frequency of the polymorphisms of the beta3-AR and UCP1 genes did not differ between patients with FCHL and controls. 9826220 1998
CUI: C0028754
Disease: Obesity
Obesity 		0.400 GeneticVariation disease BEFREE It was the aim of this study to examine the allelic frequency and the prevalence of the three UCP-1 genotypes in a broad caucasian cohort and to investigate the significance of this polymorphism for obesity and diabetes. 10469165 1999
CUI: C0011847
Disease: Diabetes
Diabetes 		0.100 GeneticVariation disease BEFREE It was the aim of this study to examine the allelic frequency and the prevalence of the three UCP-1 genotypes in a broad caucasian cohort and to investigate the significance of this polymorphism for obesity and diabetes. 10469165 1999
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus 		0.100 GeneticVariation group BEFREE It was the aim of this study to examine the allelic frequency and the prevalence of the three UCP-1 genotypes in a broad caucasian cohort and to investigate the significance of this polymorphism for obesity and diabetes. 10469165 1999
CUI: C0025517
Disease: Metabolic Diseases
Metabolic Diseases 		0.100 Biomarker group BEFREE Very recently, the cloning of UCP2 and UCP3, two homologues of UCP1, has renewed the field of research on the importance of respiration control in metabolic processes and metabolic diseases. 10395193 1999
CUI: C0025517
Disease: Metabolic Diseases
Metabolic Diseases 		0.100 GeneticVariation group BEFREE The recently described A-->G (-3826) point mutation within the distal region of the UCP-1 promoter is possibly involved in the development of obesity, diabetes and related metabolic disorders. 10469165 1999