Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Prenatal exposure to maternal obesity leads to significant increases in UCP1 levels and function in BAT in offspring with little impact on UCP1 levels and function in SAT and VAT.
|
29769150 |
2018 |
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, our results agree with the previously reported association between UCP1 -3826G allele and obesity and point to a gender-related effect.
|
15536594 |
2004 |
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Several obesity- and nutrient-related gene polymorphisms but not FTO and UCP variants modulate postabsorptive resting energy expenditure and fat-induced thermogenesis in obese individuals: the NUGENOB study.
|
19399022 |
2009 |
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Activation of thermogenesis in brown adipose tissue (BAT) and the ability to increase uncoupling protein 1 (UCP1) levels and mitochondrial biogenesis in white fat (termed 'browning'), has great therapeutic potential to treat obesity and its comorbidities because of the net increase in energy expenditure.
|
29396369 |
2018 |
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
As UCP1-enriched cells can consume lipids by generating heat, browning of white adipocytes is now highlighted as a promising approach for the prevention of obesity and obesity-associated metabolic diseases.
|
30132867 |
2019 |
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In mice, IFI202b overexpression caused obesity (Δ body weight at the age of 30 weeks: 10.2 ± 1.9 g vs wild-type mice) marked by hypertrophic fat mass expansion, increased expression of Zfp423 (encoding the transcription factor zinc finger protein [ZFP] 423) and white-selective genes (Tcf21, Tle3), and decreased expression of thermogenic genes (e.g.Cidea, Ucp1).
|
29478099 |
2018 |
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our data are consistent with FTO rs9939609 and UCP-1 rs6536991 common variants as contributors to obesity in the Brazilian population.
|
23134754 |
2012 |
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in uncoupling protein (UCP) genes have been strongly associated with energy expenditure and obesity.
|
23101559 |
2013 |
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Therefore, several studies investigating the role of polymorphisms in the gene encoding UCP1 in susceptibility to obesity or metabolic syndrome have been performed.
|
28100847 |
2016 |
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Mice lacking UCP1 are cold sensitive, but surprisingly not obese at room temperature.
|
19187768 |
2009 |
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to test the predictive value of presence/absence of polymorphisms/ variants in β3-adrenergic receptor (ADRB3), uncoupling protein 1 (UCP1), peroxisome proliferator-activated receptor γ (PPARγ), and adiponectin (ADIPOQ) genes in diagnosing the IR in obesity.
|
22391136 |
2012 |
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
The role of the uncoupling protein 1 (UCP1) on the development of obesity and type 2 diabetes mellitus.
|
22790465 |
2012 |
Obesity
|
0.400 |
Therapeutic
|
disease |
CTD_human |
Ectopic expression of mitochondrial uncoupling protein 1 (UCP1) in the white adipose tissue of the aP2-Ucp1 transgenic mice reduced obesity induced by genetic or dietary manipulations.
|
15592485 |
2004 |
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Uncoupling protein-1 (UCP-1), which plays a major role in thermogenesis and energy expenditure can increase the risk of obesity and can be related metabolic disorders.
|
23043591 |
2012 |
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
UCP1 expression is positively correlated with metabolic inefficiency, being increased by cold acclimation (in adults or perinatally) and overfeeding, and reduced in fasting and genetic obesity.
|
11239487 |
2001 |
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The effects of UCP-1 polymorphisms on obesity phenotypes among Korean female subjects.
|
16084837 |
2005 |
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
We examined the expression of PGC-1, PPAR gamma, insulin receptor substrate-1 (IRS-1), glucose transporter isoform-4 (GLUT-4), and mitochondrial uncoupling protein-1 (UCP-1) in adipose tissue and skeletal muscle from non-obese, non-diabetic insulin-resistant, and insulin-sensitive individuals.
|
12565902 |
2003 |
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
UCP1 is only expressed during brown fat cell differentiation and is a candidate target for treating obesity.
|
29796650 |
2018 |
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our results identify MKK6 in adipocytes as a potential therapeutic target to reduce obesity.Brown and beige adipose tissues dissipate heat via uncoupling protein 1 (UCP1).
|
29021624 |
2017 |
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
The induction of brown-like adipocytes in white adipose tissue (WAT) is a potential therapeutic target for the treatment of obesity and metabolic disorders via the ability of these cells to release excess energy as heat in association with uncoupling protein 1.
|
29334590 |
2018 |
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We conclude that ambient temperature is qualitatively determinative for the outcome of metabolic studies, that no other protein and no other mechanism can substitute for UCP1 in mediating diet-induced adrenergic thermogenesis, and that UCP1 activity can be determinative for obesity development in mice and possibly in humans.
|
19187776 |
2009 |
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Expression of UCP1 from the adipose-specific promoter in the aP2-Ucp1 transgenic mice mitigated obesity induced by genetic or dietary factors.
|
12079839 |
2002 |
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thus, our results demonstrate that the development of glucocorticoid-induced obesity is not caused by a decreased UCP1-dependent thermogenic capacity.
|
31067456 |
2019 |
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
These processes were correlated with the increased gene expression of Dio2 and Ucp-1, which represents brown adipose tissue (BAT) activation, in both WD-induced atherosclerosis and high-fat-induced obesity models.
|
31570705 |
2019 |
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Abbreviations: ALT, Alanine aminotransferase; AMPK, AMP-activated protein kinase; ATMs, Adipose tissue macrophages; BAT, Brown adipose tissue; CDDO-Im, 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid-imidazolide; CDDO-Me, CDDO-methyl ester; DIO, High-fat-diet-induced obese; FFA, Free fatty acid; FGF, Fibroblast growth factor; GTP, Glutamyl transpeptidase; HFD, High-fat diet; IKKβ, Inhibitor of κB-kinase β; IL, Interleukin; JNK, C-Jun N-terminal kinase; KD, Knockdown; Keap1, Kelch-like ECH-associated protein 1; KO, Knockout; LPS, Lipopolysaccharide; NADPH, Nicotinamide adenine dinucleotide phosphate; NAFLD, Non-alcoholic fatty liver disease; NF-κB, Nuclear factor-κB; Nrf2, Nuclear factor E2-related factor 2; ROS, Reactive oxygen species; T2D, Type 2 diabetes; TLR, Toll-like receptor; TNF, tumor necrosis factor; UCP, Uncoupling protein; WAT, White adipose tissue.
|
29898626 |
2018 |