Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Prenatal exposure to maternal obesity leads to significant increases in UCP1 levels and function in BAT in offspring with little impact on UCP1 levels and function in SAT and VAT.
|
29769150 |
2018 |
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, our results agree with the previously reported association between UCP1 -3826G allele and obesity and point to a gender-related effect.
|
15536594 |
2004 |
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Several obesity- and nutrient-related gene polymorphisms but not FTO and UCP variants modulate postabsorptive resting energy expenditure and fat-induced thermogenesis in obese individuals: the NUGENOB study.
|
19399022 |
2009 |
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Activation of thermogenesis in brown adipose tissue (BAT) and the ability to increase uncoupling protein 1 (UCP1) levels and mitochondrial biogenesis in white fat (termed 'browning'), has great therapeutic potential to treat obesity and its comorbidities because of the net increase in energy expenditure.
|
29396369 |
2018 |
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
As UCP1-enriched cells can consume lipids by generating heat, browning of white adipocytes is now highlighted as a promising approach for the prevention of obesity and obesity-associated metabolic diseases.
|
30132867 |
2019 |
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In mice, IFI202b overexpression caused obesity (Δ body weight at the age of 30 weeks: 10.2 ± 1.9 g vs wild-type mice) marked by hypertrophic fat mass expansion, increased expression of Zfp423 (encoding the transcription factor zinc finger protein [ZFP] 423) and white-selective genes (Tcf21, Tle3), and decreased expression of thermogenic genes (e.g.Cidea, Ucp1).
|
29478099 |
2018 |
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our data are consistent with FTO rs9939609 and UCP-1 rs6536991 common variants as contributors to obesity in the Brazilian population.
|
23134754 |
2012 |
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in uncoupling protein (UCP) genes have been strongly associated with energy expenditure and obesity.
|
23101559 |
2013 |
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Therefore, several studies investigating the role of polymorphisms in the gene encoding UCP1 in susceptibility to obesity or metabolic syndrome have been performed.
|
28100847 |
2016 |
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Mice lacking UCP1 are cold sensitive, but surprisingly not obese at room temperature.
|
19187768 |
2009 |
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to test the predictive value of presence/absence of polymorphisms/ variants in β3-adrenergic receptor (ADRB3), uncoupling protein 1 (UCP1), peroxisome proliferator-activated receptor γ (PPARγ), and adiponectin (ADIPOQ) genes in diagnosing the IR in obesity.
|
22391136 |
2012 |
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
The role of the uncoupling protein 1 (UCP1) on the development of obesity and type 2 diabetes mellitus.
|
22790465 |
2012 |
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Uncoupling protein-1 (UCP-1), which plays a major role in thermogenesis and energy expenditure can increase the risk of obesity and can be related metabolic disorders.
|
23043591 |
2012 |
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
UCP1 expression is positively correlated with metabolic inefficiency, being increased by cold acclimation (in adults or perinatally) and overfeeding, and reduced in fasting and genetic obesity.
|
11239487 |
2001 |
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The effects of UCP-1 polymorphisms on obesity phenotypes among Korean female subjects.
|
16084837 |
2005 |
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
We examined the expression of PGC-1, PPAR gamma, insulin receptor substrate-1 (IRS-1), glucose transporter isoform-4 (GLUT-4), and mitochondrial uncoupling protein-1 (UCP-1) in adipose tissue and skeletal muscle from non-obese, non-diabetic insulin-resistant, and insulin-sensitive individuals.
|
12565902 |
2003 |
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
UCP1 is only expressed during brown fat cell differentiation and is a candidate target for treating obesity.
|
29796650 |
2018 |
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our results identify MKK6 in adipocytes as a potential therapeutic target to reduce obesity.Brown and beige adipose tissues dissipate heat via uncoupling protein 1 (UCP1).
|
29021624 |
2017 |
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
The induction of brown-like adipocytes in white adipose tissue (WAT) is a potential therapeutic target for the treatment of obesity and metabolic disorders via the ability of these cells to release excess energy as heat in association with uncoupling protein 1.
|
29334590 |
2018 |
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We conclude that ambient temperature is qualitatively determinative for the outcome of metabolic studies, that no other protein and no other mechanism can substitute for UCP1 in mediating diet-induced adrenergic thermogenesis, and that UCP1 activity can be determinative for obesity development in mice and possibly in humans.
|
19187776 |
2009 |
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Expression of UCP1 from the adipose-specific promoter in the aP2-Ucp1 transgenic mice mitigated obesity induced by genetic or dietary factors.
|
12079839 |
2002 |
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thus, our results demonstrate that the development of glucocorticoid-induced obesity is not caused by a decreased UCP1-dependent thermogenic capacity.
|
31067456 |
2019 |
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
These processes were correlated with the increased gene expression of Dio2 and Ucp-1, which represents brown adipose tissue (BAT) activation, in both WD-induced atherosclerosis and high-fat-induced obesity models.
|
31570705 |
2019 |
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Abbreviations: ALT, Alanine aminotransferase; AMPK, AMP-activated protein kinase; ATMs, Adipose tissue macrophages; BAT, Brown adipose tissue; CDDO-Im, 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid-imidazolide; CDDO-Me, CDDO-methyl ester; DIO, High-fat-diet-induced obese; FFA, Free fatty acid; FGF, Fibroblast growth factor; GTP, Glutamyl transpeptidase; HFD, High-fat diet; IKKβ, Inhibitor of κB-kinase β; IL, Interleukin; JNK, C-Jun N-terminal kinase; KD, Knockdown; Keap1, Kelch-like ECH-associated protein 1; KO, Knockout; LPS, Lipopolysaccharide; NADPH, Nicotinamide adenine dinucleotide phosphate; NAFLD, Non-alcoholic fatty liver disease; NF-κB, Nuclear factor-κB; Nrf2, Nuclear factor E2-related factor 2; ROS, Reactive oxygen species; T2D, Type 2 diabetes; TLR, Toll-like receptor; TNF, tumor necrosis factor; UCP, Uncoupling protein; WAT, White adipose tissue.
|
29898626 |
2018 |
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
JZ expression of thyroid hormone signaling components Trh, Dio2, Trα, and Ucp2 were negatively associated with maternal leptin. mRNA expression of TRH, TRβ and UCP1 were also decreased in term placenta from OB women.
|
25449029 |
2014 |