|
Retinal Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Among seven common polymorphisms in the promoter region, 5'-untranslated region (UTR) and 3'UTR of the VEGF gene, genotype distribution of the C(-634)G polymorphism differed significantly (P = 0.011) between patients with (n = 150) and without (n = 118) retinopathy, and the C allele was significantly increased in patients with retinopathy compared with those without retinopathy (P = 0.0037).
|
11978667 |
2002 |
|
Retinal Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Vascular endothelial growth factor (VEGF) plays a pivotal role in the development of neovascularization in both physiological and pathological processes, e.g., developmental and reproductive angiogenesis, proliferative retinopathies, and cancers.
|
9815760 |
1997 |
|
Retinal Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Transcription factors regulate GPR91-mediated expression of VEGF in hypoxia-induced retinopathy.
|
28374767 |
2017 |
|
Retinal Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Melatonin attenuated retinal neovascularization and neuroglial dysfunction by inhibition of HIF-1α-VEGF pathway in oxygen-induced retinopathy mice.
|
29411894 |
2018 |
|
Retinal Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Certain SNPs in intron 2 of the VEGF gene are associated with early progression of retinopathy in Japanese patients with type 1 diabetes, though their contributions were weakened by glycemic exposure.
|
19263526 |
2009 |
|
Retinal Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
RNAi of VEGF and HIF-1alpha may have therapeutic potential in ischemic retinal diseases like diabetic retinopathy.
|
17869204 |
2007 |
|
Retinal Diseases
|
0.400 |
Biomarker
|
group |
CTD_human |
Further, SERPINA3K blocked the overexpression of proinflammatory factors, such as VEGF, TNF-alpha, and ICAM-1, in the retina of the OIR model and in cultured retinal cells exposed to hypoxia.
|
19324842 |
2009 |
|
Retinal Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
VEGF mRNA and protein expression was higher in the OIR and OIR control groups, compared with the normoxia and OIR‑treated groups.
|
30664207 |
2019 |
|
Retinal Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Here, however, we show by cell-specific depletion of Vhl in a mouse model of retinal ischemia (oxygen-induced retinopathy, OIR) that myeloid-derived HIFs promote VEGF and bFGF expression and enhance vascular regeneration in association with improved density and organization of the astrocytic network.
|
31583505 |
2019 |
|
Retinal Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
In this study, we addressed the potential relationship between prominin-1 (prom1) and vascular endothelial growth factor (VEGFA) in diabetes-induced retinopathy.
|
29076766 |
2018 |
|
Retinal Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Moreover, the expressions of HB-EGF and VEGF were increased after laser-induced CNV and oxygen-induced retinopathy, and their expression sites were located around the neovascular areas.
|
29191924 |
2018 |
|
Retinal Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
To investigate whether vector-based HIF-1alpha -targeted shRNA expression system (pSUPER(siHIF-1alpha)) can inhibit HIF-1alpha and VEGF expression in vitro and suppress retinal neovascularization in the murine model of oxygen-induced retinopathy.
|
18853324 |
2008 |
|
Retinal Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
For the investigation of sevoflurane's effect on angiogenesis, the angiogenesis and VEGF expression in the retina were measured after administering sevoflurane in an oxygen-induced retinopathy mice model.
|
29464332 |
2018 |
|
Retinal Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Pharmacologic intervention that inhibits the signals elicited by atRA may be effective in treating VEGF-mediated retinopathies.
|
11980848 |
2002 |
|
Retinal Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
This study suggests that melatonin may have potential value in the prevention and treatment of various retinal diseases associated with increase of VEGF, vascular leakage and angiogenesis.
|
27409056 |
2017 |
|
Retinal Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Meta-analysis of association between the -2578C/A polymorphism of the vascular endothelial growth factor and retinopathy in type 2 diabetes in Asians and Caucasians.
|
24751925 |
2014 |
|
Retinal Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Significantly elevated levels of serum VEGF and highest VEGF expression were found among PDR subjects compared to DNR or NPDR subjects.
|
25956512 |
2015 |
|
Retinal Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Vascular endothelial growth factor (VEGF) is a key regulator of angiogenesis and thus contributes to many vasoproliferative retinopathies including retinopathy of prematurity.
|
25605522 |
2015 |
|
Retinal Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Previous studies using a candidate gene approach have uncovered a number of genetic loci that may shape this risk, such as the VEGF gene for retinopathy, the ELMO1 gene for nephropathy, and the ADIPOQ gene for coronary artery disease.
|
20835900 |
2010 |
|
Retinal Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We examined the possible association of the VEGF gene polymorphisms with diabetic nephropathy and retinopathy in type 2 diabetes patients.
|
17121786 |
2007 |
|
Retinal Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Using RNA interference for targeted inhibition of VEGF isoforms in conjunction with IGF-I may be preferable for suppression of HREC overgrowth in vasoproliferative retinopathies such as ROP.
|
30093937 |
2018 |
|
Retinal Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
The newly developed anti-Tspan12 antibody has therapeutic effects in vasoproliferative retinopathy and can enhance the potency of existing anti- vascular endothelial growth factor agents.
|
28356444 |
2017 |
|
Retinal Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The peroxisome proliferator-activated receptor-gamma (PPARgamma) gene has been recently associated with type 2 diabetes, obesity and traits depending on VEGF expression (e.g. retinopathy).
|
15782399 |
2005 |
|
Retinal Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
However, until now only a handful number of genetic variants were reported to be associated with either nephropathy (ACE, ELMO1, FRMD3, and AKR1B1) or retinopathy (VEGF, AKR1B1, and EPO), and only a few studies were carried out for genetic susceptibility to cardiovascular diseases (ADIPOQ, GLUL) in patients with diabetes.
|
25169573 |
2014 |
|
Retinal Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
CCR7 and VEGF mRNA were expressed at higher levels in the OIR and OIR control groups than in the normoxia and OIR treated groups.
|
28730075 |
2017 |