|
Retinal Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Vascular endothelial growth factor (VEGF) plays a pivotal role in the development of neovascularization in both physiological and pathological processes, e.g., developmental and reproductive angiogenesis, proliferative retinopathies, and cancers.
|
9815760 |
1997 |
|
Retinal Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Furthermore, the concentrations of VEGF are elevated in the aqueous and vitreous humors of patients with proliferative retinopathies such as the diabetic retinopathy.
|
10469350 |
1999 |
|
Retinal Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Furthermore, the concentrations of VEGF are elevated in the aqueous and vitreous humors of patients with proliferative retinopathies such as the diabetic retinopathy.
|
10494799 |
1999 |
|
Retinal Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Retinal VEGF mRNA levels were measured in a murine model of oxygen-induced retinopathy during vaso-obliterative and hypoxic phases.
|
11023552 |
2000 |
|
Retinal Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Vitreal macrophages express vascular endothelial growth factor in oxygen-induced retinopathy.
|
11345346 |
2000 |
|
Retinal Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Among seven common polymorphisms in the promoter region, 5'-untranslated region (UTR) and 3'UTR of the VEGF gene, genotype distribution of the C(-634)G polymorphism differed significantly (P = 0.011) between patients with (n = 150) and without (n = 118) retinopathy, and the C allele was significantly increased in patients with retinopathy compared with those without retinopathy (P = 0.0037).
|
11978667 |
2002 |
|
Retinal Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Pharmacologic intervention that inhibits the signals elicited by atRA may be effective in treating VEGF-mediated retinopathies.
|
11980848 |
2002 |
|
Retinal Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
The process of retinal neovascularization in ROP and in animal models of oxygen-induced retinopathy is complex, and involves angiogenic factors, such as vascular endothelial growth factor, and basement membrane components.
|
12930159 |
2003 |
|
Retinal Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The VEGF -460 genotype was predictive of retinopathy, even after controlling for blood pressure, glycemic control, duration of diabetes, and obesity (P = 0.02).
|
14988276 |
2004 |
|
Retinal Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The peroxisome proliferator-activated receptor-gamma (PPARgamma) gene has been recently associated with type 2 diabetes, obesity and traits depending on VEGF expression (e.g. retinopathy).
|
15782399 |
2005 |
|
Retinal Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We examined the possible association of the VEGF gene polymorphisms with diabetic nephropathy and retinopathy in type 2 diabetes patients.
|
17121786 |
2007 |
|
Retinal Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
These data demonstrate that multiple VEGFA variants are associated with the development of severe retinopathy in type 1 diabetes.
|
17513698 |
2007 |
|
Retinal Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
RNAi of VEGF and HIF-1alpha may have therapeutic potential in ischemic retinal diseases like diabetic retinopathy.
|
17869204 |
2007 |
|
Retinal Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Our results suggest that HIF-1 may be involved in angiogenesis by controlling the expression of VEGF in vivo and provide a possible strategy for the treatment of angiogenesis by targeting the HIF-1 alpha in ischemic retinopathies.
|
17947829 |
2007 |
|
Retinal Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
To investigate whether vector-based HIF-1alpha -targeted shRNA expression system (pSUPER(siHIF-1alpha)) can inhibit HIF-1alpha and VEGF expression in vitro and suppress retinal neovascularization in the murine model of oxygen-induced retinopathy.
|
18853324 |
2008 |
|
Retinal Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
In an ischemic retinopathy model or a transgenic model in which the rhodopsin promoter drives expression of vascular endothelial growth factor (VEGF) in photoreceptor there was significantly more NV in Sod1(-/-) compared to Sod1(+/+) mice.
|
19142872 |
2009 |
|
Retinal Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Certain SNPs in intron 2 of the VEGF gene are associated with early progression of retinopathy in Japanese patients with type 1 diabetes, though their contributions were weakened by glycemic exposure.
|
19263526 |
2009 |
|
Retinal Diseases
|
0.400 |
Biomarker
|
group |
CTD_human |
Further, SERPINA3K blocked the overexpression of proinflammatory factors, such as VEGF, TNF-alpha, and ICAM-1, in the retina of the OIR model and in cultured retinal cells exposed to hypoxia.
|
19324842 |
2009 |
|
Retinal Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
CNV in PXE-associated retinopathy is believed to be mediated by the action of vascular endothelial growth factor (VEGF).
|
19483196 |
2009 |
|
Retinal Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Ischaemia-induced retinal neovascularization and vascular leakage in the conditional VEGF knockout mice were analysed with fluorescein angiography, quantification of proliferative neovascular cells, immunohistochemistry, and immunoblotting using an oxygen-induced retinopathy model.
|
19768732 |
2009 |
|
Retinal Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Administration of recombinant VEGF(165)b inhibits ocular angiogenesis in mouse models of retinopathy and age-related macular degeneration, and colorectal carcinoma and metastatic melanoma.
|
19909248 |
2009 |
|
Retinal Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Association between the -634C/G polymorphisms of the vascular endothelial growth factor and retinopathy in type 2 diabetes: a meta-analysis.
|
20591524 |
2010 |
|
Retinal Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Previous studies using a candidate gene approach have uncovered a number of genetic loci that may shape this risk, such as the VEGF gene for retinopathy, the ELMO1 gene for nephropathy, and the ADIPOQ gene for coronary artery disease.
|
20835900 |
2010 |
|
Retinal Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The extended retinopathy is concomitant with prolonged overexpression of retinal vascular endothelial growth factor in PWG pups.
|
21056995 |
2010 |
|
Retinal Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
We suggest that "early worsening" of retinopathy results when diabetic patients with minimal to moderate retinopathy, whose retinal circulation and, hence, retinal oxygen supply is compromised, are placed on a "tight" glucose control regimen and their major remaining retinal energy source is reduced, with VEGF up-regulation as a compensatory mechanism.
|
21158590 |
2011 |