Retinal Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Among seven common polymorphisms in the promoter region, 5'-untranslated region (UTR) and 3'UTR of the VEGF gene, genotype distribution of the C(-634)G polymorphism differed significantly (P = 0.011) between patients with (n = 150) and without (n = 118) retinopathy, and the C allele was significantly increased in patients with retinopathy compared with those without retinopathy (P = 0.0037).
|
11978667 |
2002 |
Retinal Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Vascular endothelial growth factor (VEGF) plays a pivotal role in the development of neovascularization in both physiological and pathological processes, e.g., developmental and reproductive angiogenesis, proliferative retinopathies, and cancers.
|
9815760 |
1997 |
Retinal Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Transcription factors regulate GPR91-mediated expression of VEGF in hypoxia-induced retinopathy.
|
28374767 |
2017 |
Retinal Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Melatonin attenuated retinal neovascularization and neuroglial dysfunction by inhibition of HIF-1α-VEGF pathway in oxygen-induced retinopathy mice.
|
29411894 |
2018 |
Retinal Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Certain SNPs in intron 2 of the VEGF gene are associated with early progression of retinopathy in Japanese patients with type 1 diabetes, though their contributions were weakened by glycemic exposure.
|
19263526 |
2009 |
Retinal Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
RNAi of VEGF and HIF-1alpha may have therapeutic potential in ischemic retinal diseases like diabetic retinopathy.
|
17869204 |
2007 |
Retinal Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
VEGF mRNA and protein expression was higher in the OIR and OIR control groups, compared with the normoxia and OIR‑treated groups.
|
30664207 |
2019 |
Retinal Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Here, however, we show by cell-specific depletion of Vhl in a mouse model of retinal ischemia (oxygen-induced retinopathy, OIR) that myeloid-derived HIFs promote VEGF and bFGF expression and enhance vascular regeneration in association with improved density and organization of the astrocytic network.
|
31583505 |
2019 |
Retinal Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
In this study, we addressed the potential relationship between prominin-1 (prom1) and vascular endothelial growth factor (VEGFA) in diabetes-induced retinopathy.
|
29076766 |
2018 |
Retinal Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Moreover, the expressions of HB-EGF and VEGF were increased after laser-induced CNV and oxygen-induced retinopathy, and their expression sites were located around the neovascular areas.
|
29191924 |
2018 |
Retinal Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
To investigate whether vector-based HIF-1alpha -targeted shRNA expression system (pSUPER(siHIF-1alpha)) can inhibit HIF-1alpha and VEGF expression in vitro and suppress retinal neovascularization in the murine model of oxygen-induced retinopathy.
|
18853324 |
2008 |
Retinal Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
For the investigation of sevoflurane's effect on angiogenesis, the angiogenesis and VEGF expression in the retina were measured after administering sevoflurane in an oxygen-induced retinopathy mice model.
|
29464332 |
2018 |
Retinal Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Pharmacologic intervention that inhibits the signals elicited by atRA may be effective in treating VEGF-mediated retinopathies.
|
11980848 |
2002 |
Retinal Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
This study suggests that melatonin may have potential value in the prevention and treatment of various retinal diseases associated with increase of VEGF, vascular leakage and angiogenesis.
|
27409056 |
2017 |
Retinal Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Meta-analysis of association between the -2578C/A polymorphism of the vascular endothelial growth factor and retinopathy in type 2 diabetes in Asians and Caucasians.
|
24751925 |
2014 |
Retinal Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Significantly elevated levels of serum VEGF and highest VEGF expression were found among PDR subjects compared to DNR or NPDR subjects.
|
25956512 |
2015 |
Retinal Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Vascular endothelial growth factor (VEGF) is a key regulator of angiogenesis and thus contributes to many vasoproliferative retinopathies including retinopathy of prematurity.
|
25605522 |
2015 |
Retinal Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Previous studies using a candidate gene approach have uncovered a number of genetic loci that may shape this risk, such as the VEGF gene for retinopathy, the ELMO1 gene for nephropathy, and the ADIPOQ gene for coronary artery disease.
|
20835900 |
2010 |
Retinal Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We examined the possible association of the VEGF gene polymorphisms with diabetic nephropathy and retinopathy in type 2 diabetes patients.
|
17121786 |
2007 |
Retinal Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Using RNA interference for targeted inhibition of VEGF isoforms in conjunction with IGF-I may be preferable for suppression of HREC overgrowth in vasoproliferative retinopathies such as ROP.
|
30093937 |
2018 |
Retinal Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
The newly developed anti-Tspan12 antibody has therapeutic effects in vasoproliferative retinopathy and can enhance the potency of existing anti- vascular endothelial growth factor agents.
|
28356444 |
2017 |
Retinal Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The peroxisome proliferator-activated receptor-gamma (PPARgamma) gene has been recently associated with type 2 diabetes, obesity and traits depending on VEGF expression (e.g. retinopathy).
|
15782399 |
2005 |
Retinal Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
However, until now only a handful number of genetic variants were reported to be associated with either nephropathy (ACE, ELMO1, FRMD3, and AKR1B1) or retinopathy (VEGF, AKR1B1, and EPO), and only a few studies were carried out for genetic susceptibility to cardiovascular diseases (ADIPOQ, GLUL) in patients with diabetes.
|
25169573 |
2014 |
Retinal Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
CCR7 and VEGF mRNA were expressed at higher levels in the OIR and OIR control groups than in the normoxia and OIR treated groups.
|
28730075 |
2017 |
Retinal Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
We hypothesised that the initial reduction of central macular thickness by ranibizumab should be maximum in severe diabetic retinopathy until the levels of VEGF decreases to the levels observed in eyes with mild retinopathy.MethodsConsecutive patients with centre-involving DMO (central subfield thickness (CSFT)>300 μm) who had three consecutive monthly ranibizumab injections followed by as needed therapy were included.
|
28452992 |
2017 |