VEGFA, vascular endothelial growth factor A, 7422

N. diseases: 1899; N. variants: 59
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0004096
Disease: Asthma
Asthma
0.400 Biomarker disease BEFREE Increased VEGF serum concentration is characteristic of patients with asthma, especially those with irreversible bronchoconstriction. 30740942 2019
CUI: C0004096
Disease: Asthma
Asthma
0.400 Biomarker disease BEFREE Insights into the importance of vascular endothelial growth factor and angiogenesis in asthma pathogenesis now lead to potential new therapeutic possibilities and elucidate why recent advances in asthma therapeutics have been so successful. 18188016 2008
CUI: C0004096
Disease: Asthma
Asthma
0.400 Biomarker disease LHGDN Vascular endothelial growth factor-induced secretion of fibronectin is ERK dependent. 14633511 2004
CUI: C0004096
Disease: Asthma
Asthma
0.400 Biomarker disease BEFREE Vascular endothelial growth factor (VEGF) has been implicated in inflammatory and airway blood vessel remodeling in asthmatics. 27579513 2016
CUI: C0004096
Disease: Asthma
Asthma
0.400 Biomarker disease LHGDN Acute and chronic changes of vascular endothelial growth factor (VEGF) in induced sputum of toluene diisocyanate (TDI)-induced asthma patients. 15201500 2004
CUI: C0004096
Disease: Asthma
Asthma
0.400 Biomarker disease BEFREE Abnormal histone methylation is responsible for increased vascular endothelial growth factor 165a secretion from airway smooth muscle cells in asthma. 22689881 2012
CUI: C0004096
Disease: Asthma
Asthma
0.400 Biomarker disease BEFREE Importantly, MFG-E8 apparently alleviated OVA-driven airway remodeling, which were evidenced by declined secretion of important mediators of airway remodeling, including transforming growth factor-β1, matrix metalloproteinase 9, ADAM8, and vascular endothelial growth factor, and reduced airway collagen deposition and inhibited goblet cell hyperplasia in OVA-induced asthma in mice. 30076648 2018
CUI: C0004096
Disease: Asthma
Asthma
0.400 Biomarker disease CTD_human One of the histological hallmarks of inflammation is angiogenesis, but the possible role of vascular endothelial growth factor (VEGF), a potent angiogenic cytokine, in TDI-induced asthma is unknown. 11907124 2002
CUI: C0004096
Disease: Asthma
Asthma
0.400 Biomarker disease BEFREE These findings provide evidence that VEGF may play an important role in angiogenesis and subsequent airway remodeling in bronchial asthma. 11398081 2001
CUI: C0004096
Disease: Asthma
Asthma
0.400 GeneticVariation disease BEFREE We sought to examine the relevance of VEGF gene polymorphisms to asthma in the Chinese Han population. 27173321 2016
CUI: C0004096
Disease: Asthma
Asthma
0.400 GeneticVariation disease BEFREE The ADAM33 rs528557/S2 and the VEGFA rs833069 SNPs were associated with Thai asthmatics, as well as with other populations worldwide. 31586488 2019
CUI: C0004096
Disease: Asthma
Asthma
0.400 GeneticVariation disease BEFREE The objective of the present study was to determine whether VEGF single nucleotide polymorphisms (SNPs) are associated with asthma, lung function and airway responsiveness. 19196819 2009
CUI: C0004096
Disease: Asthma
Asthma
0.400 GeneticVariation disease BEFREE We sought to evaluate the effects of variations in the gene coding VEGF receptor (VEGFR) 2 on intermediate phenotypes of asthma in the Korean population. 16630933 2006
CUI: C0004096
Disease: Asthma
Asthma
0.400 GeneticVariation disease BEFREE We studied VEGFA gene variants and plasma levels and the development of lung function, bronchial hyperresponsiveness and asthma in childhood. 24152156 2013
CUI: C0004096
Disease: Asthma
Asthma
0.400 GeneticVariation disease BEFREE The -2549 -2567 del18 Polymorphism in VEGF and Irreversible Bronchoconstriction in Asthmatics. 30574871 2019