|
leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
In addition, vaccination of C57BL/6 mice with Ad-tWT1 generated WT1-specific cell-mediated and humoral immune responses and conferred protection against challenge with the leukemia cell line, mWT1-C1498.
|
19351755 |
2009 |
|
leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
WT1 gene expression has been proposed as a useful marker of minimal residual disease in leukaemia.
|
19650884 |
2009 |
|
leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The Wilms' tumor 1 (WT1) gene is overexpressed in leukemia and various types of solid tumor, such as lung and colorectal cancer, and plays an oncogenic role in their tumorigenesis.
|
20180815 |
2010 |
|
leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The WT1 gene is highly expressed in leukemia and various types of solid tumors, whereas WT1 is a tumor marker convenient for the detection of minimal residual disease of leukemia.
|
20395243 |
2010 |
|
leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
This review examines evidence from preclinical experiments and initial clinical trials to critically assess both the potential and current limitations of adoptive transfer of donor T-cells sensitized to selected minor alloantigens of the host or to peptide epitopes of proteins, differentially expressed by clonogenic leukemia cells, such as the Wilms tumor protein, WT-1, as a strategy to treat or prevent recurrence of leukemia in the post-transplant period.
|
20537908 |
2010 |
|
leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Most cases of leukemia show hTERT and WT1 gene overexpression.
|
21314483 |
2011 |
|
leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Wilms' tumor (WT1) protein is one of the potent tumor antigens inducing immunological response in mouse and human, because WT1 is over expressed in many types of leukemia and various kinds of solid tumors.
|
21963635 |
2011 |
|
leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The expression of WT1 gene was measured according to the European Leukaemia Net recommendations.
|
23231003 |
2013 |
|
leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Of these, 230 were monitored concurrently for minimal residual disease (MRD) by flow cytometry (FCM) for leukemia-associated aberrant immune phenotypes and by RQ-PCR for the expression of the Wilms tumor (WT1) gene.
|
24631740 |
2014 |
|
leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Subsequent research has shown that the WT1 gene in many other cases acts as an oncogene, most prominently in leukaemia and lung cancer (even though these cancer forms can emerge as a result of many other aetiological factors).
|
25189877 |
2015 |
|
leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Due to its immunogenicity and overexpression concomitant with leukemia progression, Wilms tumor protein 1 (WT1) is of particular interest for immunotherapy of AML relapse after allogeneic hematopoietic stem cell transplantation (allo-HSCT).
|
27896368 |
2017 |
|
leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The molecular basis of diseases such as Wilms tumor, WAGR, Denys-Drash or Frasier syndromes are congenital WT1 mutations, while somatic mutations of this gene occur in acute and chronic myeloid leukemia, myelodysplastic syndrome and also in some other blood neoplasms, as acute lymphoblood leukemia.
|
28791954 |
2017 |
|
leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Recently, we developed a WT1 oral cancer vaccine using a recombinant Bifidobacterium displaying WT1 protein, which can efficiently deliver WT1 protein to the gut immune system, and we demonstrated that this oral cancer vaccine had a significant anti-tumor effect in a C1498-WT1 murine leukemia syngeneic tumor model.
|
29048978 |
2018 |
|
leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The Wilms tumor 1 (WT1) is an intracellular oncogenic transcription factor that is an attractive target for cancer immunotherapy because of its overexpression in a wide range of leukemias and solid tumors, and a low level of expression in normal adult tissues.
|
30045840 |
2018 |
|
leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Wilms tumor 1 (WT1) oncoprotein is an intracellular oncogenic transcription factor which is barely expressed in normal adult tissues but over expressed in a variety of leukemias and solid cancers.
|
31408937 |
2019 |