PSCA, prostate stem cell antigen, 8000

N. diseases: 111; N. variants: 14
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms 		0.010 Biomarker group BEFREE The results suggest that PSCA may have a tumor-promoting function in brain tumors and is a potential target for their therapy. 29435040 2018
CUI: C0007133
Disease: Carcinoma, Papillary
Carcinoma, Papillary 		0.010 AlteredExpression disease BEFREE In brain tumors, PSCA was expressed in medulloblastoma and glioma, and its expression was also observed in papilloma and papillary carcinoma of the choroid plexus, ependymoma and meningioma. 29435040 2018
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.010 AlteredExpression disease BEFREE Correlation between prostate stem cell antigen gene expression and oral squamous cell carcinoma. 29844822 2018
CUI: C0014474
Disease: Ependymoma
Ependymoma 		0.010 AlteredExpression disease BEFREE In brain tumors, PSCA was expressed in medulloblastoma and glioma, and its expression was also observed in papilloma and papillary carcinoma of the choroid plexus, ependymoma and meningioma. 29435040 2018
CUI: C0017638
Disease: Glioma
Glioma 		0.010 AlteredExpression disease BEFREE In brain tumors, PSCA was expressed in medulloblastoma and glioma, and its expression was also observed in papilloma and papillary carcinoma of the choroid plexus, ependymoma and meningioma. 29435040 2018
CUI: C0025149
Disease: Medulloblastoma
Medulloblastoma 		0.010 AlteredExpression disease BEFREE In brain tumors, PSCA was expressed in medulloblastoma and glioma, and its expression was also observed in papilloma and papillary carcinoma of the choroid plexus, ependymoma and meningioma. 29435040 2018
CUI: C0025286
Disease: Meningioma
Meningioma 		0.010 AlteredExpression disease BEFREE In brain tumors, PSCA was expressed in medulloblastoma and glioma, and its expression was also observed in papilloma and papillary carcinoma of the choroid plexus, ependymoma and meningioma. 29435040 2018
CUI: C0278510
Disease: Childhood Medulloblastoma
Childhood Medulloblastoma 		0.010 AlteredExpression disease BEFREE In brain tumors, PSCA was expressed in medulloblastoma and glioma, and its expression was also observed in papilloma and papillary carcinoma of the choroid plexus, ependymoma and meningioma. 29435040 2018
CUI: C0278874
Disease: Adult Ependymoma
Adult Ependymoma 		0.010 AlteredExpression disease BEFREE In brain tumors, PSCA was expressed in medulloblastoma and glioma, and its expression was also observed in papilloma and papillary carcinoma of the choroid plexus, ependymoma and meningioma. 29435040 2018
CUI: C0278876
Disease: Adult Medulloblastoma
Adult Medulloblastoma 		0.010 AlteredExpression disease BEFREE In brain tumors, PSCA was expressed in medulloblastoma and glioma, and its expression was also observed in papilloma and papillary carcinoma of the choroid plexus, ependymoma and meningioma. 29435040 2018
CUI: C0278877
Disease: Adult Meningioma
Adult Meningioma 		0.010 AlteredExpression disease BEFREE In brain tumors, PSCA was expressed in medulloblastoma and glioma, and its expression was also observed in papilloma and papillary carcinoma of the choroid plexus, ependymoma and meningioma. 29435040 2018
CUI: C0796611
Disease: Newly Diagnosed Childhood Ependymoma
Newly Diagnosed Childhood Ependymoma 		0.010 AlteredExpression disease BEFREE In brain tumors, PSCA was expressed in medulloblastoma and glioma, and its expression was also observed in papilloma and papillary carcinoma of the choroid plexus, ependymoma and meningioma. 29435040 2018
CUI: C1335302
Disease: Pancreatic Ductal Adenocarcinoma
Pancreatic Ductal Adenocarcinoma 		0.010 AlteredExpression disease BEFREE Patient-derived pancreatic ductal adenocarcinoma xenografts (PDX-PDACs) were grown subcutaneously in NSG mice and screened for PSCA expression by immuno-PET. 29602820 2018
CUI: C1762616
Disease: Meningioma, benign, no ICD-O subtype
Meningioma, benign, no ICD-O subtype 		0.010 AlteredExpression disease BEFREE In brain tumors, PSCA was expressed in medulloblastoma and glioma, and its expression was also observed in papilloma and papillary carcinoma of the choroid plexus, ependymoma and meningioma. 29435040 2018
CUI: C1851584
Disease: Childhood Ependymoma
Childhood Ependymoma 		0.010 AlteredExpression disease BEFREE In brain tumors, PSCA was expressed in medulloblastoma and glioma, and its expression was also observed in papilloma and papillary carcinoma of the choroid plexus, ependymoma and meningioma. 29435040 2018
CUI: C3266262
Disease: Multiple Chronic Conditions
Multiple Chronic Conditions 		0.010 Biomarker disease BEFREE PSCA measurement is a candidate for inclusion in multi-parametric prognostic prostate cancer tests. 29855276 2018
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.010 Biomarker disease BEFREE Taken together, our studies demonstrate that PSCA and MUC1 are both promising CAR T cell targets in NSCLC and that the combinatorial targeting of these antigens could further enhance the antitumor efficacy of CAR T cells. 28405515 2017
CUI: C0279565
Disease: Invasive Lobular Breast Carcinoma
Invasive Lobular Breast Carcinoma 		0.010 AlteredExpression disease BEFREE PSCA protein expression was observed in 58.9% (33/56), 40.3% (29/72), and 3.6% (2/56) of IMPC, IDC-NST, and ILC samples, respectively. 28755148 2017
CUI: C3472608
Disease: Micropapillary carcinoma
Micropapillary carcinoma 		0.010 Biomarker disease BEFREE Detection of PSCA protein and gene amplification may help manage and predict the prognosis of IMPC patients. 28755148 2017
CUI: C3838947
Disease: Invasive micropapillary carcinoma of breast
Invasive micropapillary carcinoma of breast 		0.010 AlteredExpression disease BEFREE Amplification and overexpression of PSCA at 8q24 in invasive micropapillary carcinoma of breast. 28755148 2017
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix 		0.010 GeneticVariation disease BEFREE In summary, the PSCA rs2294008 polymorphism may serve as a biomarker of cervical cancer, particularly of early-stage cervical cancer. 27001215 2016
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma 		0.010 GeneticVariation disease BEFREE In summary, the PSCA rs2294008 polymorphism may serve as a biomarker of cervical cancer, particularly of early-stage cervical cancer. 27001215 2016
CUI: C0334037
Disease: Intestinal metaplasia
Intestinal metaplasia 		0.010 GeneticVariation phenotype BEFREE PSCA TT genotype is associated with a more than a threefold increase in the prevalence and the extent of gastric mucosal IM compared to C allele carriers among H. pylori-infected Bhutanese. 26706772 2016
CUI: C4048328
Disease: cervical cancer
cervical cancer 		0.010 GeneticVariation disease BEFREE In summary, the PSCA rs2294008 polymorphism may serve as a biomarker of cervical cancer, particularly of early-stage cervical cancer. 27001215 2016
CUI: C4733094
Disease: progesterone receptor-positive breast cancer
progesterone receptor-positive breast cancer 		0.010 GeneticVariation disease BEFREE Therefore, among Chinese Han women, the PSCA rs2294008, rs2978974, and rs2976392 minor alleles are associated with increased breast cancer risk especially in progesterone receptor positive breast cancer patients, with breast cancer risk in postmenopausal women, and with high lymph node metastasis risk, respectively. 27050280 2016