|
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Our results verified that certain CLPTM1L polymorphisms are protective factors against lung cancer in a southern Chinese Han population and may be potential diagnostic and molecular markers for lung cancer patients.
|
26852039 |
2016 |
|
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
A common sequence variant, rs401681, located in an intronic region of CLPTM1L, has been reported to be associated with lung cancer risk based on genome-wide association study.
|
24386361 |
2013 |
|
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Our results verified that genetic variants of CLPTM1L contribute to lung cancer susceptibility in the northwest Chinese Han population.
|
25526467 |
2014 |
|
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Genetic variants in TERT and CLPTM1L may affect the susceptibility of lung cancer, especially adenocarcinoma in Chinese women nonsmokers.
|
23738012 |
2013 |
|
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The differences in risk level between Israeli Jews and non-Jews could not be explained by lung cancer genetic risk variants which were identified in GWAS (genes in the CHRNA5, TERT and CLPTM1L regions).
|
25924736 |
2015 |
|
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Individuals, including the smoking population, who carry both the TERT rs2736098 and CLPTM1L rs401681 T alleles are more likely to develop lung cancer.
|
28789383 |
2017 |
|
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Genetic variant in CLPTM1L confers reduced risk of lung cancer: a replication study in Chinese and a meta-analysis.
|
25422207 |
2014 |
|
Carcinoma of lung
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Immunohistochemistry was used to examine CLPTM1L expression levels on a tissue microarray containing 73 sets of human lung cancer specimens with adjacent normal tissue.
|
27062701 |
2016 |
|
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The results of the present study suggest a potential association between CLPTM1L variants and lung cancer risk in the Chinese Han populations.
|
25155038 |
2014 |
|
Carcinoma of lung
|
0.200 |
Biomarker
|
disease |
BEFREE |
Functional characterization of CLPTM1L as a lung cancer risk candidate gene in the 5p15.33 locus.
|
22675468 |
2012 |
|
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Chromosome 5p15.33, containing TERT and CLPTM1L genes, was recently identified as one of the susceptible regions for lung cancer in Caucasian populations.
|
19369581 |
2009 |
|
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The long TL genetic score was significantly associated with increased risk of lung adenocarcinoma (P = 6.3 × 10(-15)), even after exclusion of a SNP residing in a known lung cancer susceptibility region (TERT-CLPTM1L) P = 6.6 × 10(-6)).
|
26138067 |
2015 |
|
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that genetic variants in the TERT-CLPTM1L gene may predispose individuals to be susceptible to LC, particularly NSCLC, in the Chinese population.
|
23359026 |
2013 |
|
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Longer telomere length in peripheral white blood cells is associated with risk of lung cancer and the rs2736100 (CLPTM1L-TERT) polymorphism in a prospective cohort study among women in China.
|
23555636 |
2013 |
|
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Lung Cancer Risk in Never-Smokers of European Descent is Associated With Genetic Variation in the 5p15.33 TERT-CLPTM1Ll Region.
|
31009812 |
2019 |
|
Carcinoma of lung
|
0.200 |
Biomarker
|
disease |
BEFREE |
CLPTM1L transferred lung cancer cell line 95-D showed no growth inhibition or cell apoptosis, but it did show inhibited sensitivity to cis-diamminedichloroplatinum(II) (cisplatin, CDDP).
|
23300716 |
2012 |
|
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
All three mapped to Chromosome 5 CLPTM1L-TERT region, previously shown to be associated with lung cancer risk in smokers and in never-smoker Asian women, and risk of other cancers including breast, ovarian, colorectal, and prostate.
|
31009812 |
2019 |
|
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
However, the joint effect of TERT and CLPTM1L variants increased the risk of lung cancer, especially squamous cell carcinoma, with an adjusted OR of 3.274.
|
24861918 |
2014 |
|
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The combined analyses identified six well-replicated SNPs with independent effects and significant lung cancer associations (P < 5.0 × 10(-8)) located in TP63 (rs4488809 at 3q28, P = 7.2 × 10(-26)), TERT-CLPTM1L (rs465498 and rs2736100 at 5p15.33, P = 1.2 × 10(-20) and P = 1.0 × 10(-27), respectively), MIPEP-TNFRSF19 (rs753955 at 13q12.12, P = 1.5 × 10(-12)) and MTMR3-HORMAD2-LIF (rs17728461 and rs36600 at 22q12.2, P = 1.1 × 10(-11) and P = 6.2 × 10(-13), respectively).
|
21725308 |
2011 |
|
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Previous genome-wide association study observed that rs401681 within CLPTM1L (CLPTM1 like) was significantly associated with lung cancer.
|
29939218 |
2018 |
|
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In summary, our results show that genetic variation in the CLPTM1L-TERT locus of chromosome 5p15.33 is directly associated with the risk of lung cancer, most notably adenocarcinoma.
|
20700438 |
2010 |
|
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In the logistic regression analysis, TERT-rs2853669, rs2736108, and CLPTM1L-rs31490 were significant associated with increased risk of lung cancer (OR = 1.46, 95% CI = 1.22-1.75; OR = 1.22, 95% CI = 1.00-1.49 and OR = 1.74, 95% CI = 1.35-2.23 under additive model, respectively).
|
23908149 |
2013 |
|
Carcinoma of lung
|
0.200 |
Biomarker
|
disease |
BEFREE |
The risk genotype at the CLPTM1L locus was associated with high expression of CLPTM1L in normal lung tissue, suggesting that cis-regulation of CLPTM1L may contribute to lung cancer risk.
|
24366883 |
2014 |
|
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Common 5p15.33 and 6p21.33 variants influence lung cancer risk.
|
18978787 |
2008 |
|
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Several genome-wide association studies (GWAS) have identified TERT-CLPTM1L as plausible causative locus for lung cancer development.
|
27982019 |
2017 |