Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Our results verified that certain CLPTM1L polymorphisms are protective factors against lung cancer in a southern Chinese Han population and may be potential diagnostic and molecular markers for lung cancer patients.
|
26852039 |
2016 |
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
A common sequence variant, rs401681, located in an intronic region of CLPTM1L, has been reported to be associated with lung cancer risk based on genome-wide association study.
|
24386361 |
2013 |
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Our results verified that genetic variants of CLPTM1L contribute to lung cancer susceptibility in the northwest Chinese Han population.
|
25526467 |
2014 |
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Genetic variants in TERT and CLPTM1L may affect the susceptibility of lung cancer, especially adenocarcinoma in Chinese women nonsmokers.
|
23738012 |
2013 |
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The differences in risk level between Israeli Jews and non-Jews could not be explained by lung cancer genetic risk variants which were identified in GWAS (genes in the CHRNA5, TERT and CLPTM1L regions).
|
25924736 |
2015 |
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Individuals, including the smoking population, who carry both the TERT rs2736098 and CLPTM1L rs401681 T alleles are more likely to develop lung cancer.
|
28789383 |
2017 |
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Genetic variant in CLPTM1L confers reduced risk of lung cancer: a replication study in Chinese and a meta-analysis.
|
25422207 |
2014 |
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The results of the present study suggest a potential association between CLPTM1L variants and lung cancer risk in the Chinese Han populations.
|
25155038 |
2014 |
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Chromosome 5p15.33, containing TERT and CLPTM1L genes, was recently identified as one of the susceptible regions for lung cancer in Caucasian populations.
|
19369581 |
2009 |
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The long TL genetic score was significantly associated with increased risk of lung adenocarcinoma (P = 6.3 × 10(-15)), even after exclusion of a SNP residing in a known lung cancer susceptibility region (TERT-CLPTM1L) P = 6.6 × 10(-6)).
|
26138067 |
2015 |
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that genetic variants in the TERT-CLPTM1L gene may predispose individuals to be susceptible to LC, particularly NSCLC, in the Chinese population.
|
23359026 |
2013 |
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Longer telomere length in peripheral white blood cells is associated with risk of lung cancer and the rs2736100 (CLPTM1L-TERT) polymorphism in a prospective cohort study among women in China.
|
23555636 |
2013 |
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Lung Cancer Risk in Never-Smokers of European Descent is Associated With Genetic Variation in the 5p15.33 TERT-CLPTM1Ll Region.
|
31009812 |
2019 |
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
All three mapped to Chromosome 5 CLPTM1L-TERT region, previously shown to be associated with lung cancer risk in smokers and in never-smoker Asian women, and risk of other cancers including breast, ovarian, colorectal, and prostate.
|
31009812 |
2019 |
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
However, the joint effect of TERT and CLPTM1L variants increased the risk of lung cancer, especially squamous cell carcinoma, with an adjusted OR of 3.274.
|
24861918 |
2014 |
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The combined analyses identified six well-replicated SNPs with independent effects and significant lung cancer associations (P < 5.0 × 10(-8)) located in TP63 (rs4488809 at 3q28, P = 7.2 × 10(-26)), TERT-CLPTM1L (rs465498 and rs2736100 at 5p15.33, P = 1.2 × 10(-20) and P = 1.0 × 10(-27), respectively), MIPEP-TNFRSF19 (rs753955 at 13q12.12, P = 1.5 × 10(-12)) and MTMR3-HORMAD2-LIF (rs17728461 and rs36600 at 22q12.2, P = 1.1 × 10(-11) and P = 6.2 × 10(-13), respectively).
|
21725308 |
2011 |
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Previous genome-wide association study observed that rs401681 within CLPTM1L (CLPTM1 like) was significantly associated with lung cancer.
|
29939218 |
2018 |
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In summary, our results show that genetic variation in the CLPTM1L-TERT locus of chromosome 5p15.33 is directly associated with the risk of lung cancer, most notably adenocarcinoma.
|
20700438 |
2010 |
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In the logistic regression analysis, TERT-rs2853669, rs2736108, and CLPTM1L-rs31490 were significant associated with increased risk of lung cancer (OR = 1.46, 95% CI = 1.22-1.75; OR = 1.22, 95% CI = 1.00-1.49 and OR = 1.74, 95% CI = 1.35-2.23 under additive model, respectively).
|
23908149 |
2013 |
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Common 5p15.33 and 6p21.33 variants influence lung cancer risk.
|
18978787 |
2008 |
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Several genome-wide association studies (GWAS) have identified TERT-CLPTM1L as plausible causative locus for lung cancer development.
|
27982019 |
2017 |
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
As a result, 15 SNPs on or near 12 genes and one miRNA with strong evidence of association with lung cancer risk were identified, including TERT (rs2736098), CHRNA3 (rs1051730), AGPHD1 (rs8034191), CLPTM1L (rs401681 and rs402710), BAT3 (rs3117582), TRNAA (rs4324798), ERCC2 (Lys751Gln), miR-146a2 (rs2910164), CYP1B1 (Arg48Gly), GSTM1 (null/present), SOD2 (C47T), IL-10 (-592C/A and -819C/T), and TP53 (intron 6).
|
29110844 |
2017 |
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Association between CLPTM1L polymorphisms (rs402710 and rs401681) and lung cancer susceptibility: evidence from 27 case-control studies.
|
24907075 |
2014 |
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
This analysis provides evidence that TERT-CLPTM1L variants may influence the risk of lung cancer outside the context of tobacco smoking.
|
19955392 |
2010 |
Carcinoma of lung
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, this meta-analysis suggested that CLPTM1L rs31489 was a potential biomarker for lung cancer risk in Caucasians.
|
24535780 |
2014 |