|
Primary malignant neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
As TKTL1 appears to be a valid biomarker for cancer prognosis, the aim of the current study was to correlate its expression with tumor stage, probability of tumor recurrence and survival, in a series of colorectal cancer patients.
|
21980427 |
2011 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In this study it was demonstrated that a) JFC12T10 detects multiple unspecific bands in Western blots, b) a 75-kDa band hitherto referred to as TKTL-1 corresponds to a nuclear protein and c) immunohistochemical detection of TKTL-1 in benign leiomyomas yields an expression pattern identical to that found in a variety of malignant tumors.
|
20596653 |
2010 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Overexpression of TKTL1 in HNSCC cells promoted cellular proliferation and enhanced tumor growth in vitro and in vivo.
|
20103683 |
2010 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
TKTL1 is reported to play a pivotal role in carcinogenesis and may have important implications in the nutrition and future treatment of patients with cancer.
|
19290028 |
2009 |
|
Bilirubin measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia.
|
19419973 |
2009 |
|
Bilirubin measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia.
|
19419973 |
2009 |
|
Bilirubin level result
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia.
|
19419973 |
2009 |
|
Primary malignant neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
TKTL1 is reported to play a pivotal role in carcinogenesis and may have important implications in the nutrition and future treatment of patients with cancer.
|
19290028 |
2009 |
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
A mutated transketolase transcript (TKTL1) has been found up-regulated in different human malignancies, and strong TKTL1 protein expression has been associated with aggressiveness and poor patient survival in several epithelial cancers.
|
18615628 |
2008 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Increased levels of TKTL1 transcript were detected in 50 of 55 analyzed tumors compared with their corresponding normal tissues.
|
18615628 |
2008 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These results indicate that TKTL1 gene influences total transketolase activity and cell proliferation in human nasopharyngeal carcinoma cells, suggesting that TKTL1 gene plays an important role on glycometabolism in tumors and it might become a novel target for tumor gene therapy.
|
18296915 |
2008 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These results indicate that TKTL1 gene influences total transketolase activity and cell proliferation in human hepatoma cells, suggesting that TKTL1 gene plays an important role on glycometabolism in tumors and it might become a novel target for tumor gene therapy.
|
17321041 |
2007 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We have detected upregulation of a mutated transketolase transcript (TKTL1) in human malignancies, whereas transketolase (TKT) and transketolase-like-2 (TKTL2) transcripts were not upregulated.
|
16465194 |
2006 |
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We propose that TKTL1 upregulation is a common phenomenon in GC and cancer of the GEJ leading to an enhanced, oxygen-independent glucose usage which might contribute to a more aggressive tumor growth.
|
16969476 |
2006 |
|
Primary malignant neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We propose that TKTL1 upregulation is a common phenomenon in GC and cancer of the GEJ leading to an enhanced, oxygen-independent glucose usage which might contribute to a more aggressive tumor growth.
|
16969476 |
2006 |
|
Primary malignant neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Expression of transketolase TKTL1 predicts colon and urothelial cancer patient survival: Warburg effect reinterpreted.
|
16465194 |
2006 |
|
Colorectal Carcinoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
Biomarkers Apo10 and TKTL1: Epitope-detection in monocytes (EDIM) as a new diagnostic approach for cholangiocellular, pancreatic and colorectal carcinoma.
|
31771043 |
2020 |
|
Carcinogenesis
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
The results obtained in this study suggest that pentose phosphate pathway and its key enzyme TKTL1 is altered throughout the CaP tumorigenesis, and this pathway merits further investigation.
|
30119993 |
2018 |
|
Colorectal Carcinoma
|
0.060 |
PosttranslationalModification
|
disease |
BEFREE |
Subsequently, we screened four genes (ALOX15, GHRHR, TFPI2 and TKTL1) with aberrant methylation and aberrant hydroxymethylation at some genome position by functional enrichment analysis as candidate genes associated with colorectal cancer.
|
27546520 |
2016 |
|
Colorectal Carcinoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
We show that high TKTL1 in tumor tissue can lead to poor survival in colorectal cancer.
|
26650256 |
2016 |
|
Colorectal Carcinoma
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
Dysregulation of TKTL1 expression also leads to poor prognosis in patients with urothelial and colorectal cancer.
|
26349965 |
2015 |
|
Carcinogenesis
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
Transketolase-like-1 (TKTL1), which is a rate-limiting enzyme in the non-oxidative part of the pentose-phosphate pathway, has been demonstrated to promote carcinogenesis through enhanced aerobic glycolysis.
|
26349965 |
2015 |
|
Carcinogenesis
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
Expression of IGF-R1, glycolysis-related proteins (GLUT-1, HK 2, LDHA, TKTL1), and mitochondrial enzymes (SDHA, SDHB, ATP synthase) were significantly increased in the carcinogenesis of OSCC.
|
25048361 |
2014 |
|
Colorectal Carcinoma
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
We studied TKTL1 mRNA and protein expression in CRC cell lines and human CRC biopsies by quantitative real-time PCR, Western blotting and immunohistochemistry.
|
24193262 |
2013 |
|
Colorectal Carcinoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
METHODOLODY/PRINCIPAL FINDINGS: Tumor tissues from 63 patients diagnosed with colorectal cancer at different stages of progression were analyzed for TKTL1 by immunohistochemistry.
|
21980427 |
2011 |