|
Carcinogenesis
|
0.060 |
AlteredExpression
|
phenotype |
BEFREE |
We used TKTL1 siRNA to observe the effect of reduced TKTL1 expression on gastric cancer tumorigenesis in a nude mice xenograft model and on proliferation in vitro.
|
20200485 |
2010 |
|
Carcinogenesis
|
0.060 |
AlteredExpression
|
phenotype |
BEFREE |
TKTL1 is activated by promoter hypomethylation and contributes to head and neck squamous cell carcinoma carcinogenesis through increased aerobic glycolysis and HIF1alpha stabilization.
|
20103683 |
2010 |
|
Carcinogenesis
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
TKTL1 is reported to play a pivotal role in carcinogenesis and may have important implications in the nutrition and future treatment of patients with cancer.
|
19290028 |
2009 |
|
Neoplasm Metastasis
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
TKTL1 plays a major role in anaerobic glycolysis of tumor cells, leading to destruction of the basal membrane and metastasis as well as in controlling cell cycle.
|
31771043 |
2020 |
|
Malignant neoplasm of colon and/or rectum
|
0.050 |
Biomarker
|
disease |
BEFREE |
We show that high TKTL1 in tumor tissue can lead to poor survival in colorectal cancer.
|
26650256 |
2016 |
|
Malignant neoplasm of colon and/or rectum
|
0.050 |
PosttranslationalModification
|
disease |
BEFREE |
Subsequently, we screened four genes (ALOX15, GHRHR, TFPI2 and TKTL1) with aberrant methylation and aberrant hydroxymethylation at some genome position by functional enrichment analysis as candidate genes associated with colorectal cancer.
|
27546520 |
2016 |
|
Neoplasm Metastasis
|
0.050 |
AlteredExpression
|
phenotype |
BEFREE |
No correlation was observed between cytoplasmatic or nuclear TKTL1 expression and tumor stage, grade or the presence of metastases.
|
25572961 |
2015 |
|
Neoplasm Metastasis
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
TKTL1 promotes cell proliferation and metastasis in esophageal squamous cell carcinoma.
|
26349965 |
2015 |
|
Malignant neoplasm of colon and/or rectum
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Dysregulation of TKTL1 expression also leads to poor prognosis in patients with urothelial and colorectal cancer.
|
26349965 |
2015 |
|
Malignant neoplasm of colon and/or rectum
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Hypoxia induces the expression of transketolase-like 1 in human colorectal cancer.
|
24193262 |
2013 |
|
Neoplasm Metastasis
|
0.050 |
AlteredExpression
|
phenotype |
BEFREE |
To our knowledge, few studies have explored the association between variations in TKTL1 expression in the primary tumor and metastasis formation.
|
21980427 |
2011 |
|
Malignant neoplasm of colon and/or rectum
|
0.050 |
Biomarker
|
disease |
BEFREE |
METHODOLODY/PRINCIPAL FINDINGS: Tumor tissues from 63 patients diagnosed with colorectal cancer at different stages of progression were analyzed for TKTL1 by immunohistochemistry.
|
21980427 |
2011 |
|
Neoplasm Metastasis
|
0.050 |
AlteredExpression
|
phenotype |
BEFREE |
Significant differences in TKTL1 transcript levels were found between cases of PTC with and without LN metastases.
|
18615628 |
2008 |
|
Degenerative polyarthritis
|
0.040 |
Biomarker
|
disease |
BEFREE |
After adjustment for other covariates, including statin therapy, this association was significant for both hand OA in men and women [OR 1.10(1.03-1.17), p < 0.01] (per unit standard deviation decrease in CRAE) and TKR prevalence [OR 1.15 (1.01-1.32), p = 0.04], especially for men [OR 1.22 (1.00-1.51) p = 0.04] and also for incident TKRs in men [OR 1.50 (1.07-2.10), p = 0.04].
|
30671597 |
2019 |
|
Malignant neoplasm of stomach
|
0.040 |
Biomarker
|
disease |
BEFREE |
Our study aimed to perform a molecular characterization of HER2-positive AGC and investigate the role of PI3K/Akt/mTOR signaling pathway activation and TKR gene copy number (GCN) gains as predictive biomarkers in HER2-positive AGC treated with trastuzumab.
|
29700210 |
2018 |
|
Degenerative polyarthritis
|
0.040 |
Biomarker
|
disease |
BEFREE |
Baseline subject demographics, risk factors, KL score, cartilage WORMS score, presence of meniscus tear, and cartilage T<sub>2</sub> were used to predict the development of moderate/severe OA (KL = 3-4 or WOMAC pain ≥5 or total knee replacement [TKR]) over 8 years.
|
29143404 |
2018 |
|
Stomach Carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Our study aimed to perform a molecular characterization of HER2-positive AGC and investigate the role of PI3K/Akt/mTOR signaling pathway activation and TKR gene copy number (GCN) gains as predictive biomarkers in HER2-positive AGC treated with trastuzumab.
|
29700210 |
2018 |
|
Degenerative polyarthritis
|
0.040 |
Biomarker
|
disease |
BEFREE |
Preoperative and 6-month postoperative data on function (Short Form-36 Physical Component Summary [PCS] score), joint pain (Hip disability and Osteoarthritis Outcome Score and Knee injury and Osteoarthritis Outcome Score), and body mass index (BMI) were collected from a national sample of 2,040 patients who had undergone THR and 2,964 who had undergone TKR from May 2011 to March 2013.
|
28719557 |
2017 |
|
Degenerative polyarthritis
|
0.040 |
Biomarker
|
disease |
BEFREE |
Background and purpose - Little is know about patterns of sick leave in connection with total hip and knee joint replacement (THR and TKR) in patients with osteoarthritis (OA).
|
27996342 |
2017 |
|
Malignant neoplasm of stomach
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
This study investigated the expression of TKTL1 and p63 in gastric cancer and their clinical significance.
|
26406948 |
2015 |
|
Stomach Carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
This study investigated the expression of TKTL1 and p63 in gastric cancer and their clinical significance.
|
26406948 |
2015 |
|
Malignant neoplasm of stomach
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
We used TKTL1 siRNA to observe the effect of reduced TKTL1 expression on gastric cancer tumorigenesis in a nude mice xenograft model and on proliferation in vitro.
|
20200485 |
2010 |
|
Stomach Carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
We used TKTL1 siRNA to observe the effect of reduced TKTL1 expression on gastric cancer tumorigenesis in a nude mice xenograft model and on proliferation in vitro.
|
20200485 |
2010 |
|
Malignant neoplasm of stomach
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
We propose that TKTL1 upregulation is a common phenomenon in GC and cancer of the GEJ leading to an enhanced, oxygen-independent glucose usage which might contribute to a more aggressive tumor growth.
|
16969476 |
2006 |
|
Stomach Carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
We propose that TKTL1 upregulation is a common phenomenon in GC and cancer of the GEJ leading to an enhanced, oxygen-independent glucose usage which might contribute to a more aggressive tumor growth.
|
16969476 |
2006 |