|
3-Methylglutaconic aciduria type 2
|
0.010 |
Biomarker
|
disease |
BEFREE |
We also show, by extensive flow cytometry analysis, that the type II apoptosis pathway was blocked at the mitochondrial level and that the mitochondria of patients with Barth syndrome cannot bind active caspase-8.
|
23523468 |
2013 |
|
Acoustic Neuroma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The CT haplotype of the two CASP8 polymorphisms was associated with significantly increased risk of meningioma (OR, 1.7; 95% CI, 1.1-2.6), but was not associated with risk of glioma or acoustic neuroma.
|
17684142 |
2007 |
|
Acute glaucoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Kaempferol attenuated retinal ganglion cell death by suppressing NLRP1/NLRP3 inflammasomes and caspase-8 via inhibiting NF-κB and JNK pathways in acute glaucoma.
|
30560913 |
2019 |
|
Acute glaucoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
These findings demonstrate collectively a critical role of caspase-8 in transducing TLR4-mediated IL-1β production and RGC death and highlight signal transduction in a caspase-1-dependent NLRP1/NLRP3 inflammasome pathway and a caspase-1-independent pathway in acute glaucoma.
|
25024200 |
2014 |
|
Acute heart failure
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We observed significant upregulation of apoptosis in monocytes exposed to CRS type 1 plasma compared to AHF, with increased levels of caspase-3 (p < 0.01), caspase-9 (p < 0.01), and caspase-8 (p < 0.03) showing activation of both intrinsic and extrinsic pathways.
|
29847820 |
2018 |
|
Acute Lung Injury
|
0.200 |
Therapeutic
|
disease |
RGD |
Ischemic preconditioning attenuates acute lung injury after partial liver transplantation.
|
29755641 |
2018 |
|
Acute lymphocytic leukemia
|
0.030 |
Biomarker
|
disease |
BEFREE |
Our results showed that low Taxol concentrations triggered caspase-8- and caspase-10-dependent apoptosis in the CCRF-HSB-2 human lymphoblastic leukemia cell line, and induced the down-regulation of c-FLIP(S) and c-FLIP(L).
|
16579975 |
2006 |
|
Acute lymphocytic leukemia
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
We demonstrate that the Smac mimetic BV6 and Dexa cooperate to trigger necroptotic cell death in acute lymphoblastic leukemia (ALL) cells that are deficient in caspase activation due to absent caspase-8 expression or pharmacological inhibition by the caspase inhibitor zVAD.fmk, since genetic silencing or pharmacological inhibition of RIP3 or MLKL significantly rescue BV6/Dexa-induced necroptosis.
|
27834956 |
2017 |
|
Acute lymphocytic leukemia
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Primary tumor cells from children with ALL were evaluated for expression levels of the caspase-8 protein, were amplified in nonobese diabetic/severe combined immunodeficient mice, transfected with siRNA, and evaluated for their chemosensitivity in vitro.
|
22010212 |
2011 |
|
Acute periodontitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The mitochondrial-centered intrinsic pathway involving caspase-9 and AIF, and the extrinsic pathway involving caspase-8 are significant for aggressive periodontitis.
|
30311940 |
2019 |
|
Acute Promyelocytic Leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, these findings indicate that 23-HUA induces apoptosis in HL-60 human promyelocytic leukemia cells through formation of DISC and caspase-8 activation leading to loss of <i>ΔΨ<sub>m</sub></i> and caspase-3 activation.
|
30551620 |
2018 |
|
Acute viral hepatitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In addition, it is of particular interest that caspase 8 siRNA treatment was successful not only in acute liver failure mediated by specific Fas agonistic agents (Jo2 and AdFasL) but also in acute liver failure mediated by Adwt, which is an animal model reflecting multiple molecular mechanisms involved in human acute viral hepatitis.
|
12810955 |
2003 |
|
Adenocarcinoma
|
0.320 |
Biomarker
|
group |
CTD_human |
Association between polymorphisms in cancer-related genes and early onset of esophageal adenocarcinoma.
|
21472143 |
2011 |
|
Adenocarcinoma
|
0.320 |
Biomarker
|
group |
BEFREE |
These results suggest that Adv-caspase-8 may be a good combination partner of TRAIL and enables TRAIL to be a more potent anticancer agent in a wide range of adenocarcinoma cells which demonstrate low expression of caspase-8.
|
15645141 |
2005 |
|
Adenocarcinoma
|
0.320 |
AlteredExpression
|
group |
BEFREE |
Adenocarcinomas derived from the lung in addition to high caspase-8 expression are characterized by increased expression of DR4 compared with adjacent non-neoplastic tissues.
|
23470529 |
2013 |
|
Adenocarcinoma Of Esophagus
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In Kaplan-Meier analyses, rs2070744 of NOS3, rs720321 of BCL2, and rs1035142 of CASP8 were also significantly associated with early onset of EA.
|
21472143 |
2011 |
|
Adenocarcinoma of lung (disorder)
|
0.040 |
Biomarker
|
disease |
BEFREE |
Microarray analysis explored the GMDS-mediated molecular network and revealed that the CASP8-CDKN1A axis might be critical for lung adenocarcinoma development.
|
29843634 |
2018 |
|
Adenocarcinoma of lung (disorder)
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Blocking DR4 or lowering caspase-8 expression significantly reduced apoptosis in NSCLC cell lines, indicating the importance of DR4 and signifying that higher levels of caspase-8 in lung adenocarcinomas make them more susceptible to TRAIL treatment.
|
23470529 |
2013 |
|
Adenocarcinoma of lung (disorder)
|
0.040 |
PosttranslationalModification
|
disease |
BEFREE |
Dasatinib promotes paclitaxel-induced necroptosis in lung adenocarcinoma with phosphorylated caspase-8 by c-Src.
|
27195913 |
2016 |
|
Adenocarcinoma of lung (disorder)
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
To explore the relationship between tagSNPs or haplotypes of CASP8 and the efficacy of platinum-based chemotherapy in advanced lung adenocarcinoma patients of China, we recruited 555 advanced adenocarcinoma patients.
|
28278082 |
2017 |
|
Adenocarcinoma, Basal Cell
|
0.300 |
Biomarker
|
disease |
CTD_human |
Association between polymorphisms in cancer-related genes and early onset of esophageal adenocarcinoma.
|
21472143 |
2011 |
|
Adenocarcinoma, Oxyphilic
|
0.300 |
Biomarker
|
disease |
CTD_human |
Association between polymorphisms in cancer-related genes and early onset of esophageal adenocarcinoma.
|
21472143 |
2011 |
|
Adenocarcinoma, Tubular
|
0.300 |
Biomarker
|
disease |
CTD_human |
Association between polymorphisms in cancer-related genes and early onset of esophageal adenocarcinoma.
|
21472143 |
2011 |
|
Adenoma
|
0.020 |
AlteredExpression
|
group |
LHGDN |
Caspase-8 expression was up-regulated in rectal adenomas.
|
18716417 |
2008 |
|
Adenoma
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Immunohistochemical results showed caspase-8 up-regulation in adenomas (p = 0.014), and caspase-10 down-regulation in adenomas (p = 0.034) and cancers (p < 0.001) compared with normal mucosa samples.
|
18716417 |
2008 |