|
Carpal Tunnel Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
It was found that the AA genotype of CASP8 rs13113 (T/A) was independently associated with increased risk for CTS.
|
31692049 |
2020 |
|
Ileitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Accordingly, depending on the microbial environment, isogenic Casp8ΔIEC mice either exclusively developed ileitis or suffered from pathologies in several parts of the gastrointestinal tract.
|
31276162 |
2020 |
|
Marijuana Abuse
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, combined administration of Can and Nan increased oxidative stress (significantly increased malondialdehyde and nitric oxide levels and reduced glutathione content), elevated brain pro-inflammatory cytokines (tumour necrosis factor alpha and interleukin 1 beta), and upregulated caspase-3, caspase-8, and caspase-9 mRNA expression and cytochrome c levels.
|
31704101 |
2020 |
|
Acute periodontitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The mitochondrial-centered intrinsic pathway involving caspase-9 and AIF, and the extrinsic pathway involving caspase-8 are significant for aggressive periodontitis.
|
30311940 |
2019 |
|
Bacterial Infections
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Macrophages lacking caspase-8 or the adaptor FADD have defective inflammatory cytokine expression and inflammasome priming in response to bacterial infection or TLR stimulation.
|
31147458 |
2019 |
|
Cachexia
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Protein levels of phosphorylated p53 (Ser46), activated caspase 8 (Asp384) and 9 (Asp315) were also increased in the skeletal muscle of CC.
|
31466311 |
2019 |
|
Cystitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We conclude that decreased AChE activities associated with diabetes and likely cystitis provide complementary factor to the described in literature altered expression of mACh receptor subtypes linked to diabetes as well as to cystitis to produce dramatic modification of cholinergic NMT.
|
31299187 |
2019 |
|
Cytomegalovirus Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
Caspase-8-dependent control of NK- and T cell responses during cytomegalovirus infection.
|
31098689 |
2019 |
|
Dermatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Previous studies have reported that cellular FLICE (FADD-like ICE)-inhibitory protein plays a crucial role in prevention of keratinocytes from TNF-α-dependent apoptosis and blocking of dermatitis.
|
29596938 |
2019 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.010 |
Biomarker
|
disease |
BEFREE |
Compared to the control, increased reactive oxygen species (ROS), protein levels of cytochrome C, cleaved caspase-8 and caspase-3, myocardial damage and impeded left ventricular (LV) function were observed in the hearts of all treated groups and maximally in T1DM + CO-HFD-treated rats. mRNA of all NFAT members (NFAT1-4) were not affected by any treatment.
|
31030170 |
2019 |
|
Diabetic Retinopathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
To evaluate the effects of etanercept on the expression of Fas, tumor necrosis factor-alpha (TNF-α) and caspase-8 in the early stage of the apoptotic pathway in diabetic rats, and to explore the therapeutic effect of etanercept on diabetic retinopathy.
|
31341796 |
2019 |
|
Epilepsy
|
0.010 |
Biomarker
|
disease |
BEFREE |
An important correlation between TNF-α vs caspase-8, and Cholesterol vs. Triglycerides was observed in the epilepsy group with VV genotype.
|
31212050 |
2019 |
|
Molluscum Contagiosum
|
0.010 |
Biomarker
|
disease |
BEFREE |
MC159 is a viral FLIP (FLICE inhibitory protein) encoded by the molluscum contagiosum virus (MCV) enabling MCV to evade antiviral immunity and to establish persistent infections in humans.
|
30842330 |
2019 |
|
Periodontal Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Because apoptosis is involved in periodontal disease, this study evaluated caspase-8, -9, and AIF in periodontal disease.
|
30311940 |
2019 |
|
Periodontitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Elevated levels of receptor-interacting protein serine-threonine kinases -1 (RIPK1), phosphorylated RIPK3, mixed lineage kinase domain-like protein (MLKL), phosphorylated MLKL and FLIP<sub>L</sub> were observed in gingival tissues collected from patients with untreated chronic periodontitis; whereas no difference in caspase 8 was observed between the periodontitis and healthy control group.
|
30814594 |
2019 |
|
Aggressive Periodontitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The mitochondrial-centered intrinsic pathway involving caspase-9 and AIF, and the extrinsic pathway involving caspase-8 are significant for aggressive periodontitis.
|
30311940 |
2019 |
|
Retinopathy of Prematurity
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taking these data together, we show that Casp-8 acts in a cell death-independent manner in ECs to regulate the formation of the retina vasculature and that Casp-8 in ECs is mechanistically involved in the pathophysiology of ROP.
|
31454332 |
2019 |
|
Stomatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Their data have shown that Gag-CASP8-VLPs, pseudotyped by the stomatitis virus G protein (VSV-G), can efficiently enter and deliver active CASP8 into breast cancer cells, leading to massive cell apoptosis and death.
|
30620218 |
2019 |
|
Yersinia infections
|
0.010 |
Biomarker
|
group |
BEFREE |
In particular, GSDMD is activated by inflammasome-activated caspases-1/-4/-5/-11 as well as a caspase-8-mediated pathway during Yersinia infection.
|
31455540 |
2019 |
|
Malignant neoplasm of oropharynx
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
CASP8 (rs3834129) and CASP3 (rs4647601) polymorphisms in oropharynx cancer risk, tumor cell differentiation, and prognosis in a cohort of the Brazilian population.
|
31587185 |
2019 |
|
Malignant neoplasm of penis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our in vitro experiments suggested CASP8 was involved in mediating TRAIL-induced apoptosis of penile cancer cell lines.
|
31034097 |
2019 |
|
Secondary malignant neoplasm of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
On the other hand, KLK6 re-expression at physiological levels leads to inhibition of lung metastases associated with suppression of S100 proteins (S100A4, S100A10, S100A13, S100A16) and induced CASP7 and CASP8 expression.
|
30980596 |
2019 |
|
Aortic Aneurysm, Abdominal
|
0.010 |
Biomarker
|
disease |
BEFREE |
In the present study, we sought to determine the role of CD95L and its downstream target, caspase 8, in AAA progression.
|
30428004 |
2019 |
|
Congenital contractural arachnodactyly
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our data demonstrated that RAE decreased cell viability and induced apoptosis by activation of Caspase 3, Caspase 8, and Poly (ADP-ribose) polymerase (PARP) in two CCA cell lines.
|
30633583 |
2019 |
|
Cervical Squamous Cell Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Here, we report the association of Polo-like kinase (PLK) 3 expression and Caspase 8 T273 phosphorylation levels with survival among patients with cervical squamous cell carcinoma (CSCC) treated with CRT plus BT.
|
31475104 |
2019 |