|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Validation analysis by immunohistochemistry showed that HSP47 expression in patients with CRC and the number of HSP47-positive spindle cells in the tumor stroma were significantly higher compared with those in adjacent normal colonic mucosa, and the number of the latter cells increased with tumor progression.
|
27925182 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Hsp47 silencing reprogrammed human breast cancer cells to form growth-arrested and/or noninvasive structures in 3D cultures, and to limit tumor growth in xenograft assays by reducing deposition of collagen and fibronectin.
|
25744716 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Expression studies confirmed that Hsp47 is silenced in a subset of NB cell lines and tumors.
|
15231663 |
2004 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We found that overexpression of HSP47 promotes primary glioma cell tumor formation, invasion, angiogenesis, and stemlike properties.
|
27696866 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Here, we examined the expression of HSP47 in a group of glioma tumors and matched non-tumor brain tissues using qRT-PCR.
|
24595468 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Here, we construct a tumour microenvironment-responsive nanosystem, based on PEGylated polyethylenimine-coated gold nanoparticles, and utilise it to co-deliver all-trans retinoic acid (ATRA, an inducer of PSC quiescence) and siRNA targeting heat shock protein 47 (HSP47, a collagen-specific molecular chaperone) to re-educate PSCs.
|
30139933 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In this review, we highlight the fundamental aspects of the interaction between HSP47 and collagen and the recent discoveries of the role of this chaperone in different types of malignant neoplasias.
|
30128672 |
2018 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.070 |
Biomarker
|
disease |
BEFREE |
Lysate virus particles on Western blot analysis revealed p19,p24, and p53 gag protein similar to those detected in C91/PL virus particles from an adult T-cell leukemia (ATL) patient. gp46 and gp61 were also weakly detected.
|
1520534 |
1992 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.070 |
Biomarker
|
disease |
BEFREE |
Sequence analysis of an immunogenic and neutralizing domain of the human T-cell lymphoma/leukemia virus type I gp46 surface membrane protein among various primate T-cell lymphoma/leukemia virus isolates including those from a patient with both HTLV-I-associated myelopathy and adult T-cell leukemia.
|
8261424 |
1993 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.070 |
Biomarker
|
disease |
BEFREE |
The envelope of human T-cell leukemia virus type I (HTLV-I) consists of two glycoproteins gp46 and p20E.
|
2078412 |
1990 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.070 |
Biomarker
|
disease |
BEFREE |
The surface envelope glycoprotein gp46 of the human T cell leukemia virus type 1 elicits a strong immune response.
|
11242520 |
2001 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.070 |
Biomarker
|
disease |
BEFREE |
A positive correlation between the appearance of an antibody recognizing the central region (Asp197 to Leu216) on Gp46, gp46-197, and the severity of ATL has been demonstrated.
|
19134004 |
2009 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.070 |
Biomarker
|
disease |
BEFREE |
The primary protein product of the human T-cell leukemia virus type 1 (HTLV-1) env gene, gp61, is cleaved to produce both the exterior (gp46) and the transmembrane (gp21) portions of the HTLV-1 envelope protein.
|
2677406 |
1989 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.070 |
Biomarker
|
disease |
BEFREE |
Chimeric synthetic peptides from the envelope (gp46) and the transmembrane (gp21) glycoproteins for the detection of antibodies to human T-cell leukemia virus type II.
|
11708768 |
2001 |
|
Malignant Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
We also discuss recent treatments using HSP47 as a therapeutic target, and present evidences that HSP47 is an essential protein for cancer biology and a potential molecular target for chemotherapy.
|
30128672 |
2018 |
|
Malignant Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Chaperone Hsp47 Drives Malignant Growth and Invasion by Modulating an ECM Gene Network.
|
25744716 |
2015 |
|
Malignant Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
These data indicate that CBP2 product may provide a molecular target for chemotherapy and/or imaging of malignancies.
|
10842320 |
2000 |
|
Malignant Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
These findings will assist in the evaluation of roles of HSP47 in collagen misfolding and human diseases such as cancer and bone disorders.
|
30986427 |
2020 |
|
Malignant Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
These results suggest that binding of HSP47 to DDR2 increases DDR2 stability and regulates its membrane dynamics and thereby enhances cancer cell migration and invasion.
|
31570520 |
2019 |
|
Tumor Cell Invasion
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
Chaperone Hsp47 Drives Malignant Growth and Invasion by Modulating an ECM Gene Network.
|
25744716 |
2015 |
|
Tumor Cell Invasion
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
Moreover, silencing of the HSP47 gene significantly inhibited cell migration and invasion in cancer cells and the expression of HSP47 was upregulated in cancer tissues and cervical intraepithelial neoplasia (CIN), as demonstrated by immunostaining.
|
24141696 |
2013 |
|
Tumor Cell Invasion
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
HSP47 is associated with the prognosis of laryngeal squamous cell carcinoma by inhibiting cell viability and invasion and promoting apoptosis.
|
28849239 |
2017 |
|
Tumor Cell Invasion
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
HSP47 silencing reduced DDR2 protein stability, accompanied by suppressed cell migration and invasion.
|
31570520 |
2019 |
|
Tumor Cell Invasion
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
The result showed that knockdown of HSP47 inhibits glioma cell growth, migration and invasion in vitro.
|
24595468 |
2014 |
|
Tumor Progression
|
0.040 |
AlteredExpression
|
phenotype |
BEFREE |
Validation analysis by immunohistochemistry showed that HSP47 expression in patients with CRC and the number of HSP47-positive spindle cells in the tumor stroma were significantly higher compared with those in adjacent normal colonic mucosa, and the number of the latter cells increased with tumor progression.
|
27925182 |
2017 |