|
Rheumatoid Arthritis
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
However, we did not find significant association between neither BANK1 rs3733197 polymorphism nor MMEL1/TNFRSF14 rs3890745 polymorphism and RA.
|
28925718 |
2017 |
|
Rheumatoid Arthritis
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
TNFRSF6B and TNFRSF14 genes were recently associated with Crohn's disease and rheumatoid arthritis.
|
20962851 |
2011 |
|
Rheumatoid Arthritis
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
A series of bioinformatic analyses identified TNFRSF14-MMEL1 at the 1p36 locus and IKZF3-ORMDL3-GSDMB at the 17q12 locus as the genes most likely associated with RA.
|
22365150 |
2012 |
|
Rheumatoid Arthritis
|
0.380 |
Biomarker
|
disease |
BEFREE |
To study the expression of LIGHT (tumor necrosis factor superfamily 14) and herpesvirus entry mediator (HVEM; tumor necrosis factor receptor superfamily 14) in rheumatoid arthritis (RA) and to determine the regulatory role of LIGHT on the effector functions of fibroblast-like synoviocytes (FLS).
|
17393389 |
2007 |
|
Rheumatoid Arthritis
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to investigate the combined effect of the TNFRSF14 rs6684865 and TNFRSF6B rs4809330 polymorphisms in RA predisposition.
|
20187130 |
2010 |
|
Rheumatoid Arthritis
|
0.380 |
Biomarker
|
disease |
BEFREE |
Herpesvirus entry mediator-Ig treatment during immunization aggravates rheumatoid arthritis in the collagen-induced arthritis model.
|
19234211 |
2009 |
|
Rheumatoid Arthritis
|
0.380 |
AlteredExpression
|
disease |
BEFREE |
Correction: The Expression of LIGHT Was Increased and the Expression of HVEM and BTLA Were Decreased in the T Cells of Patients with Rheumatoid Arthritis.
|
28253339 |
2017 |
|
Lymphoma, Follicular
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
In the BCL-u group, TNFRSF14 mutations clustered with a FL immunophenotype.
|
27297871 |
2017 |
|
Lymphoma, Follicular
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
Acquired TNFRSF14 mutations in follicular lymphoma are associated with worse prognosis.
|
20884631 |
2010 |
|
Lymphoma, Follicular
|
0.370 |
AlteredExpression
|
disease |
BEFREE |
As lymphoma B cells can act as antigen-presenting cells, we hypothesized that TNFRSF14 aberrations that reduce HVEM expression could alter the capacity of FL B cells to stimulate allogeneic T-cell responses and impact the outcome of AHSCT.
|
27103745 |
2016 |
|
Lymphoma, Follicular
|
0.370 |
Biomarker
|
disease |
BEFREE |
Of the six cases lacking 1p36 deletion, TNFRSF14 mutations were identified in three, highlighting the strong association of 1p36/TNFRSF14 abnormalities with this follicular lymphoma variant.
|
26965583 |
2016 |
|
Lymphoma, Follicular
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
The second most commonly mutated gene in PTNFL was TNFRSF14, with a mutation frequency of 29%, similar to that seen in limited-stage typical FL (P = .35).
|
27325104 |
2016 |
|
Lymphoma, Follicular
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
Among the most notable alterations, we observed and validated deletions of 1p36 and gains of the 7p and 12q chromosomes and related oncogenes, which include some of the most recurrent oncogenic alterations in overt follicular lymphoma (TNFRSF14, EZH2, MLL2).
|
24162788 |
2014 |
|
Lymphoma, Follicular
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
Recurrent loss of heterozygosity in 1p36 associated with TNFRSF14 mutations in IRF4 translocation negative pediatric follicular lymphomas.
|
23445872 |
2013 |
|
Ulcerative Colitis
|
0.110 |
GeneticVariation
|
disease |
BEFREE |
We confirmed the associations of 10 known UC risk loci in Koreans: rs76418789 in IL23R (combined P = 1.25 × 10), rs4728142 in IRF5 (combined P = 3.17 × 10), rs1830610 near JAK2 (combined P = 2.28 × 10), rs1555791 near TNFRSF14 (combined P = 1.62 × 10), rs880790 between IL10-IL19 (combined P = 3.73 × 10), rs10185424 between IL1R2-IL1R1 (combined P = 1.54 × 10), rs6478108 in TNFSF15 (combined P = 9.28 × 10), rs861857 between UBE2L3-YDJC (combined P = 3.05 × 10), rs1801274 in FCGR2A (discovery P = 1.54 × 10), and rs17085007 between GPR12-USP12 (discovery P = 3.64 × 10).
|
26398853 |
2016 |
|
Crohn Disease
|
0.110 |
GeneticVariation
|
disease |
BEFREE |
TNFRSF6B and TNFRSF14 genes were recently associated with Crohn's disease and rheumatoid arthritis.
|
20962851 |
2011 |
|
Herpes Simplex Infections
|
0.100 |
AlteredExpression
|
group |
BEFREE |
HVEM acts as both a receptor for the canonical TNF-related ligands, LIGHT [lymphotoxin-like, exhibits inducible expression, and competes with herpes simplex virus glycoprotein D for HVEM, a receptor expressed on T lymphocytes] and lymphotoxin-α, and as a ligand for the immunoglobulin superfamily proteins BTLA (B and T lymphocyte attenuator) and CD160, a feature distinguishing HVEM from other immune regulatory molecules.
|
22017438 |
2011 |
|
Herpes Simplex Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Either herpesvirus entry mediator (HVEM, TNFRSF14) or nectin-1 (PVRL1) is sufficient for herpes simplex virus (HSV) infection of cultured cells.
|
18005714 |
2007 |
|
Herpes Simplex Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Enhanced resistance to herpes simplex virus type 1 infection in transgenic mice expressing a soluble form of herpesvirus entry mediator.
|
15016549 |
2004 |
|
Herpes Simplex Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
The cellular proteins nectin-1 and herpesvirus entry mediator (HVEM) can both mediate the entry of herpes simplex virus 1 (HSV-1).
|
26136572 |
2015 |
|
Herpes Simplex Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Herpes simplex virus glycoprotein D interferes with binding of herpesvirus entry mediator to its ligands through downregulation and direct competition.
|
20826693 |
2010 |
|
Herpes Simplex Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
The relative usage of HVEM and nectin-1 during HSV infection in vivo is not known.
|
15110526 |
2004 |
|
Herpes Simplex Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Induction of conformational changes at the N-terminus of herpes simplex virus glycoprotein D upon binding to HVEM and nectin-1.
|
24314649 |
2014 |
|
Herpes Simplex Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
CIN85 also suppressed HSV-1 growth in Chinese hamster ovary (CHO) cells expressing the receptor for herpes simplex virus entry (herpes virus entry mediator A; HVEM).
|
16223483 |
2005 |
|
Herpes Simplex Infections
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In this study, we have shown that adenovirus-expressing TNFSF14 [LIGHT (name derived from homologous to lymphotoxins, shows inducible expression, and competes with herpes simplex virus glycoprotein D for herpes virus entry mediator, a receptor expressed by T lymphocytes); Ad-LIGHT] inoculated directly into primary 4T1 tumor, a highly aggressive, spontaneously metastasizing mammary carcinoma, followed by surgical removal of the primary tumor can eradicate established and disseminated metastatic tumor cells in the peripheral tissues.
|
17641063 |
2007 |