|
Lymphoma, Follicular
|
0.370 |
CausalMutation
|
disease |
CGI |
|
|
|
|
Atherosclerosis
|
0.010 |
Biomarker
|
disease |
LHGDN |
Tumor necrosis factor receptor and ligand superfamily family members TNFRSF14 and LIGHT: new players in human atherogenesis.
|
11742858 |
2001 |
|
Herpes Simplex Infections
|
0.100 |
Biomarker
|
group |
LHGDN |
Crystallization and preliminary diffraction studies of the ectodomain of the envelope glycoprotein D from herpes simplex virus 1 alone and in complex with the ectodomain of the human receptor HveA.
|
11976496 |
2002 |
|
Rheumatoid Arthritis
|
0.380 |
AlteredExpression
|
disease |
LHGDN |
High levels of soluble herpes virus entry mediator in sera of patients with allergic and autoimmune diseases.
|
14749527 |
2003 |
|
Herpes Simplex Infections
|
0.100 |
Biomarker
|
group |
LHGDN |
Herpes simplex virus (HSV) entry requires the interaction of glycoprotein D (gD) with a cellular receptor such as herpesvirus entry mediator (HVEM or HveA) or nectin-1 (HveC).
|
12915568 |
2003 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Overexpression of LIGHT (LIGHT: homologous to lymphotoxins, indicating inducible expression, and competes with herpes simplex virus glycoprotein D for herpes virus entry mediator [HVEM/TR2]) in MDA-MB-231 human breast cancer cells was observed to suppress tumor growth in vivo.
|
12651068 |
2003 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
HVEM is constitutively expressed on the surface of tumor B cells.
|
14562115 |
2003 |
|
Herpes NOS
|
0.090 |
Biomarker
|
disease |
BEFREE |
Overexpression of LIGHT (LIGHT: homologous to lymphotoxins, indicating inducible expression, and competes with herpes simplex virus glycoprotein D for herpes virus entry mediator [HVEM/TR2]) in MDA-MB-231 human breast cancer cells was observed to suppress tumor growth in vivo.
|
12651068 |
2003 |
|
Asthma
|
0.020 |
AlteredExpression
|
disease |
LHGDN |
High levels of soluble herpes virus entry mediator in sera of patients with allergic and autoimmune diseases.
|
14749527 |
2003 |
|
Dermatitis, Atopic
|
0.020 |
AlteredExpression
|
disease |
LHGDN |
High levels of soluble herpes virus entry mediator in sera of patients with allergic and autoimmune diseases.
|
14749527 |
2003 |
|
Lymphoma, Non-Hodgkin
|
0.010 |
Biomarker
|
disease |
BEFREE |
Stimulation of non-Hodgkin's lymphoma via HVEM: an alternate and safe way to increase Fas-induced apoptosis and improve tumor immunogenicity.
|
14562115 |
2003 |
|
Adult Non-Hodgkin Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Stimulation of non-Hodgkin's lymphoma via HVEM: an alternate and safe way to increase Fas-induced apoptosis and improve tumor immunogenicity.
|
14562115 |
2003 |
|
Childhood Non-Hodgkin Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Stimulation of non-Hodgkin's lymphoma via HVEM: an alternate and safe way to increase Fas-induced apoptosis and improve tumor immunogenicity.
|
14562115 |
2003 |
|
Lymphoma, Non-Hodgkin, Familial
|
0.010 |
Biomarker
|
disease |
BEFREE |
Stimulation of non-Hodgkin's lymphoma via HVEM: an alternate and safe way to increase Fas-induced apoptosis and improve tumor immunogenicity.
|
14562115 |
2003 |
|
Herpes Simplex Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Enhanced resistance to herpes simplex virus type 1 infection in transgenic mice expressing a soluble form of herpesvirus entry mediator.
|
15016549 |
2004 |
|
Herpes Simplex Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
The relative usage of HVEM and nectin-1 during HSV infection in vivo is not known.
|
15110526 |
2004 |
|
Pseudorabies
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Both human and mouse forms of HVEM can mediate entry of HSV-1 but have no entry activity for pseudorabies virus (PRV).
|
15016549 |
2004 |
|
Infection
|
0.010 |
Biomarker
|
group |
LHGDN |
Comparative usage of herpesvirus entry mediator A and nectin-1 by laboratory strains and clinical isolates of herpes simplex virus.
|
15110526 |
2004 |
|
Herpes Simplex Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
CIN85 also suppressed HSV-1 growth in Chinese hamster ovary (CHO) cells expressing the receptor for herpes simplex virus entry (herpes virus entry mediator A; HVEM).
|
16223483 |
2005 |
|
Herpes Simplex Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
A role for herpesvirus entry mediator as the receptor for herpes simplex virus 1 entry into primary human trabecular meshwork cells.
|
16189018 |
2005 |
|
Autoimmune Diseases
|
0.060 |
Biomarker
|
group |
BEFREE |
Taken together, our data revealed an unexpected regulatory role of HVEM in T cell-mediated immune responses and autoimmune diseases.
|
15696194 |
2005 |
|
Autoimmune Diseases
|
0.060 |
Biomarker
|
group |
BEFREE |
Previous studies showed that homologous to lymphotoxin, exhibits inducible expression, competes with herpesvirus glycoprotein D for HVEM on T cells (LIGHT) transgenic (Tg) mice develop autoimmunity including intestinal inflammation with a variable time course.
|
15944326 |
2005 |
|
Autoimmune Chronic Hepatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Consistent with these findings, HVEM-/- mice exhibited increased morbidity and mortality as compared with WT mice in a model of ConA-mediated T cell-dependent autoimmune hepatitis.
|
15696194 |
2005 |
|
Autoimmune hepatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Consistent with these findings, HVEM-/- mice exhibited increased morbidity and mortality as compared with WT mice in a model of ConA-mediated T cell-dependent autoimmune hepatitis.
|
15696194 |
2005 |
|
Lupus Erythematosus, Systemic
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
We also examined the association of SNPs and haplotypes in HVEM, CD30 and CD120B with SLE in European-Caucasians.
|
16306881 |
2006 |