|
Herpes NOS
|
0.090 |
Biomarker
|
disease |
BEFREE |
We observed spontaneous osteoclastogenesis with a significant increase in OC formation and bone resorbing activity in late-stage CKD and HD patients when compared with early-stage CKD patients and healthy donors, likely due to an increased expression of RANKL and LIGHT (homologous to Lymphotoxins exhibiting Inducible expression and competing with herpes simplex virus Glycoprotein D for herpes virus entry mediator [HVEM], a receptor expressed by T lymphocytes) in PBMCs.
|
28992140 |
2018 |
|
Herpes NOS
|
0.090 |
Biomarker
|
disease |
BEFREE |
Using respiratory virus infection, we show that herpes virus entry mediator (HVEM; TNFRSF14), a member of the TNF receptor superfamily, provides key signals for MPEC persistence.
|
28864473 |
2017 |
|
Malignant Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
HVEM gene silencing significantly inhibited cancer cell proliferation in vitro and cancer growth in vivo.
|
24249528 |
2014 |
|
Malignant Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
The BTLA-HVEM checkpoint axis plays extensive roles in immunomodulation and diseases, including cancer and autoimmune disorders.
|
31562209 |
2019 |
|
Malignant Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
Tumor necrosis factor receptor superfamily member 14 (TNFRSF14) is dysregulated in certain types of cancer; however, limited data are available on the expression and function of TNFRSF14 in bladder cancer.
|
30066919 |
2018 |
|
Malignant Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
Herpesvirus entry mediator (HVEM) has been suggested to play various roles in cancer biology.
|
31313042 |
2019 |
|
Malignant Neoplasms
|
0.070 |
AlteredExpression
|
group |
BEFREE |
Abnormal HVEM expression has been described in various malignancies, but the role in AML is unknown.
|
26377688 |
2015 |
|
Malignant Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
HVEM network signaling in cancer.
|
30885361 |
2019 |
|
Malignant Neoplasms
|
0.070 |
AlteredExpression
|
group |
BEFREE |
Here we summarize the recent advances made on PD1/PD1 ligands expression in cancer and we discuss about another couple of inhibitory molecules, BTLA and its ligand HVEM and their potential role in immune escape.
|
23439006 |
2013 |
|
Autoimmune Diseases
|
0.060 |
Biomarker
|
group |
BEFREE |
The BTLA-HVEM checkpoint axis plays extensive roles in immunomodulation and diseases, including cancer and autoimmune disorders.
|
31562209 |
2019 |
|
Autoimmune Diseases
|
0.060 |
Biomarker
|
group |
BEFREE |
Accumulating evidence in recent years indicates that costimulatory signals via the subset of the TNFR superfamily molecules, OX40 (TNFRSF4), 4-1BB (TNFRSF9), CD27, DR3 (TNFRSF25), CD30 (TNFRSF8), GITR (TNFRSF18), TNFR2 (TNFRSF1B), and HVEM (TNFRSF14), which are constitutive or inducible on T cells, play important roles in protective immunity, inflammatory and autoimmune diseases, and tumor immunotherapy.
|
31758531 |
2019 |
|
Autoimmune Diseases
|
0.060 |
Biomarker
|
group |
BEFREE |
Taken together, our data revealed an unexpected regulatory role of HVEM in T cell-mediated immune responses and autoimmune diseases.
|
15696194 |
2005 |
|
Autoimmune Diseases
|
0.060 |
AlteredExpression
|
group |
BEFREE |
HVEM is broadly expressed; intersects two important immunologic signaling networks; and impacts autoimmunity, infection, and inflammation.
|
28404853 |
2017 |
|
Autoimmune Diseases
|
0.060 |
Biomarker
|
group |
BEFREE |
In conclusion, HVEM-Ig aggravates autoimmunity in collagen-induced arthritis, which is possibly mediated by interaction with B and T lymphocyte attenuator (BTLA) or CD160, despite the blockade of LIGHT.
|
19234211 |
2009 |
|
Autoimmune Diseases
|
0.060 |
Biomarker
|
group |
BEFREE |
Previous studies showed that homologous to lymphotoxin, exhibits inducible expression, competes with herpesvirus glycoprotein D for HVEM on T cells (LIGHT) transgenic (Tg) mice develop autoimmunity including intestinal inflammation with a variable time course.
|
15944326 |
2005 |
|
Primary malignant neoplasm
|
0.060 |
Biomarker
|
group |
BEFREE |
Tumor necrosis factor receptor superfamily member 14 (TNFRSF14) is dysregulated in certain types of cancer; however, limited data are available on the expression and function of TNFRSF14 in bladder cancer.
|
30066919 |
2018 |
|
Primary malignant neoplasm
|
0.060 |
Biomarker
|
group |
BEFREE |
The BTLA-HVEM checkpoint axis plays extensive roles in immunomodulation and diseases, including cancer and autoimmune disorders.
|
31562209 |
2019 |
|
Primary malignant neoplasm
|
0.060 |
Biomarker
|
group |
BEFREE |
Herpesvirus entry mediator (HVEM) has been suggested to play various roles in cancer biology.
|
31313042 |
2019 |
|
Primary malignant neoplasm
|
0.060 |
AlteredExpression
|
group |
BEFREE |
Here we summarize the recent advances made on PD1/PD1 ligands expression in cancer and we discuss about another couple of inhibitory molecules, BTLA and its ligand HVEM and their potential role in immune escape.
|
23439006 |
2013 |
|
Primary malignant neoplasm
|
0.060 |
Biomarker
|
group |
BEFREE |
HVEM network signaling in cancer.
|
30885361 |
2019 |
|
Primary malignant neoplasm
|
0.060 |
Biomarker
|
group |
BEFREE |
HVEM gene silencing significantly inhibited cancer cell proliferation in vitro and cancer growth in vivo.
|
24249528 |
2014 |
|
Secondary malignant neoplasm of lymph node
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Similarly, the high expression of HVEM was also significantly correlated with lymph node metastasis (<i>P</i>=0.007) and depth of invasion (<i>P</i>=0.011).
|
28243127 |
2017 |
|
Secondary malignant neoplasm of lymph node
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
HVEM expression was found to be significantly correlated with depth of tumor invasion and lymph node metastasis.
|
24249528 |
2014 |
|
Secondary malignant neoplasm of lymph node
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
HVEM is highly expressed in ovarian serous adenocarcinoma tissues and correlated with the patient clinicopathological features, such as TNM staging, lymph node metastasis and recurrence.
|
28365939 |
2017 |
|
Secondary malignant neoplasm of lymph node
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Our research also indicated an association between polymorphisms of HVEM and clinicopathologic features, including lymph node metastasis, estrogen receptor, progesterone receptor and P53.
|
23976978 |
2013 |