|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Adiponectin is one of the key molecules in the metabolic syndrome, and its concentration is decreased in obesity, type-2 diabetes, and coronary artery disease.
|
15123570 |
2004 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Adiponectin is an adipocyte-specific protein suggested to play a role in mediating the metabolic effects of obesity.
|
15149722 |
2004 |
|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The objective of this study was to examine the role of the adiponectin gene T45G polymorphism, located in exon 2, in PCOS, since this polymorphism has been shown to be associated with obesity and insulin resistance.
|
15178661 |
2004 |
|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Adiponectin gene variations showed an association with obesity and insulin sensitivity, and adiponectin genotypes may predict the increasing risk for type 2 diabetes in non-diabetic subjects.
|
15583845 |
2005 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Recent advances that have shed light on the pathophysiology of obesity are the recognition that 1) excess fat is deposited in liver, muscle, and pancreatic islets; 2) fat tissue secretes a large number of active signaling molecules including leptin, adiponectin, and resistin, as well as free fatty acids; and 3) activated macrophages colonize the adipose tissue.
|
15601956 |
2004 |
|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggest that these common ACDC polymorphisms do not play a major role in susceptibility to obesity or type 2 diabetes in this population.
|
15616040 |
2005 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
These data show adiponectin to be an important factor in the issue of obesity and its associated disorders, and indicate a potential future utilization of adiponectin as a drug in the treatment of metabolic syndrome.
|
15682645 |
2004 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Adiponectin was decreased in obesity and lipoatrophy, and replenishment of adiponectin ameliorated insulin resistance.
|
15725703 |
2005 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In the present study, we examined the mRNA expression of adiponectin receptors and the effects of gAD on AMPK activity and fatty acid oxidation in skeletal muscle myotubes from lean, obese, and obese type 2 diabetic subjects.
|
15769985 |
2005 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Genetic analysis of adiponectin and obesity in Hispanic families: the IRAS Family Study.
|
15843989 |
2005 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Adiponectin, acylation stimulating protein and complement C3 are altered in obesity in very young children.
|
15853826 |
2005 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The data suggest that reduced adiponectin synthesis in subcutaneous adipocytes contributes to lower serum adiponectin levels in obesity and that glucocorticoids regulate adiponectin gene expression in human adipocytes.
|
15897474 |
2005 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Circulating level of adiponectin, an adipocyte-derived protein, is reduced in states of insulin resistance such as obesity and type 2 diabetes.
|
16025741 |
2005 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Adiponectin is an adipocytokine with lowered blood levels in obesity and Type 2 diabetes mellitus.
|
16028335 |
2005 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
RGD |
Adiponectin mRNA expression levels in RT WAT were lower in obese (fa/fa) Zucker rats than in lean Zucker rats, but those in BAT were higher.
|
16092047 |
2005 |
|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Here, we investigated the expression of APM1 in adipose tissue and studied the relationship between variation in APM1 expression, the APM1 G276T polymorphism, the common PPARG Pro12Ala polymorphism and clinical features of 36 morbidly obese (body mass index (BMI) 41.5 +/- 4.9 kg/m2) nondiabetic subjects.
|
16231017 |
2006 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Low concentrations of adiponectin, the protein product of the APM1 gene, have been reported to be associated with obesity and insulin resistance.
|
16418740 |
2006 |
|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
ACDC/adiponectin and PPAR-gamma gene polymorphisms: implications for features of obesity.
|
16421345 |
2005 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Family-based analysis in 400 trios from the general population indicated association between obesity haplotype and higher adiponectin levels, suggesting a role of hyperadiponectinemia in weight gain.
|
16443793 |
2006 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Circulating adiponectin was negatively associated, whereas AdipoR1/R2 mRNA levels were positively associated with obesity, glucose and lipid levels, and insulin resistance.
|
16551730 |
2006 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
The evidence that suggests adiponectin plays a role in the relationship between obesity and insulin resistance, and also insulin resistance and cardiovascular disease, is examined.
|
16581078 |
2006 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Within MZ twin pairs, acquired obesity was significantly related to increased adipocyte size and increased adipose tissue mRNA expressions of leptin, TNFalpha and the macrophage marker CD68, and decreased mRNA expressions of adiponectin and peroxisome proliferator-activated receptor-gamma.
|
16608891 |
2006 |
|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
APM1/ACDC +276 G>T single nucleotide polymorphism, echocardiographic indexed LVM (LVM/body surface area and LVM/height(2.7)), insulin sensitivity by euglycemic clamp, and plasma adiponectin levels were analyzed in 62 obese subjects without complications (51 women and 11 men; mean age, 34.2 +/- 10.2 years; BMI, 38.6 +/- 9.1 kg/m2).
|
16648605 |
2006 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Serum adiponectin concentrations were reduced in PCOS patients compared with controls (P = 0.038) irrespective of the degree of obesity, whereas serum resistin levels were increased in overweight and obese women compared with lean subjects (P = 0.016), irrespective of their PCOS or controls status.
|
16675483 |
2006 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
We investigated the presence of adiponectin receptors in intra-abdominal adipose tissue (IAAT) in obesity and diabetes and their association with adiponectin expression and components of the metabolic syndrome and/or other metabolic factors associated with atherosclerotic cardiovascular disease (ASCVD).
|
16756736 |
2006 |