|
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Adiponectin values did not differ among these two genotypes even when categorized based on their diabetes status (normal glucose tolerance Pro12Pro 7.9 vs. Pro12Ala 7.7 microg/ml, P = 0.994; diabetes Pro12Pro 4.7 vs. Pro12Ala 5.4 microg/ml, P = 0.622).
|
17335469 |
2007 |
|
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
Adiponectin has been associated with low diabetes risk.
|
17416799 |
2007 |
|
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
In a subset of hyperglycemic L1 mice, we observed decreased mRNA expression of AdipoR2 in liver and muscle, as well as decreased peroxisome proliferator-activated receptor (PPAR)alpha target gene expression in liver, raising the possibility that deterioration of adiponectin/AdipoR2 signaling via PPARalpha activation contributes to the progression from compensated insulin resistance to diabetes.
|
17475934 |
2007 |
|
Diabetes Mellitus
|
0.400 |
AlteredExpression
|
group |
BEFREE |
In SAT, APM1 and AdipoR1 expression tended to be lower - by 0.38+/-0.22 and 0.35+/-0.22, respectively - and AdipoR2 expression was markedly depressed - by 4.82+/-1.93 - in association with obesity, whereas presence of diabetes had no additional effect.
|
17607322 |
2007 |
|
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
Adiponectin has demonstrated insulin-sensitizing, antiatherogenic, and anti-inflammatory properties, and may be an important risk factor for coronary heart disease and diabetes.
|
17618943 |
2007 |
|
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Genetic variation of the adiponectin gene is associated with obesity, MetS, and diabetes mellitus in the elderly.
|
17684226 |
2007 |
|
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
LHGDN |
Genetic variation of the adiponectin gene is associated with obesity, MetS, and diabetes mellitus in the elderly.
|
17684226 |
2007 |
|
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
Adiponectin (Adipo), an adipocyte hormone involved in the regulation of glucose and lipid metabolism, has already been identified as a potential therapeutic target for the treatment of diabetes.
|
17868184 |
2007 |
|
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
The release of adiponectin was also reduced by one-third in explants from morbidly obese diabetic women while that of IL-8 was unaffected by diabetes.
|
17895880 |
2008 |
|
Diabetes Mellitus
|
0.400 |
AlteredExpression
|
group |
BEFREE |
This study establishes that low levels of adiponectin associated with obesity, the metabolic syndrome, and diabetes favor T-lymphocyte recruitment and contribute to adaptive immune response during atherogenesis.
|
17991878 |
2008 |
|
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Two common single nucleotide polymorphisms (SNPs) at the adiponectin locus (45T>G and 276G>T) have been reported to be associated with diabetes and cardiovascular diseases.
|
18191060 |
2008 |
|
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
Adiponectin modulates lipid metabolism and liver injury in nonalcoholic fatty liver disease (NAFLD) even in the absence of obesity, dyslipidemia, and diabetes.
|
18311774 |
2008 |
|
Diabetes Mellitus
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Plasma adiponectin and skeletal muscle AdipoR2 mRNA expression are reduced in subjects with diabetes; both are likely to contribute to the observed insulin resistance.
|
18363889 |
2008 |
|
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
To determine whether adiponectin, an adipocyte-derived hormone, is a communication signal between adipocytes and the kidney, we performed studies in a cohort of patients at high risk for diabetes and kidney disease as well as in adiponectin-knockout (Ad(-/-)) mice.
|
18431508 |
2008 |
|
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The Chi-square test, multivariable logistic regression analysis with adjustment for age, sex, body mass index, and the prevalence of hypertension, hypercholesterolemia, and diabetes mellitus, as well as a stepwise forward selection procedure revealed that the 2445G-->A (Ala54Thr) polymorphism (rs1799883) of FABP2, the -108/3G-->4G polymorphism of IPF1 (S82168), the A-->G (rs2241883" genes_norm="2168">Thr94Ala) polymorphism (rs2241883) of FABP1, the G-->A (rs529038" genes_norm="6098">Asp2213Asn) polymorphism (rs529038) of ROS1, the -11377C-->G polymorphism (rs266729) of ADIPOQ, the 162A-->C polymorphism (rs4769055) of ALOX5AP, the -786T-->C polymorphism (rs2070744) of NOS3, and the 3279C-->T polymorphism (rs7291467) of LGALS2 were associated (P<0.05) with the prevalence of atherothrombotic cerebral infarction.
|
18506375 |
2008 |
|
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
Adiponectin is an abundant circulating adipocyte-derived cytokine that has beneficial effects on disorders accompanying diabetes.
|
18639522 |
2008 |
|
Diabetes Mellitus
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Participants in the Framingham Offspring Study (n = 2,543, 53% women) were measured for glycemic phenotypes and incident diabetes over 28 years of follow-up; adiponectin levels were quantified at exam 7.
|
18776141 |
2008 |
|
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
LHGDN |
The adiponectin rs17300539 G>A variant and nephropathy risk.
|
18974768 |
2008 |
|
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
We provide novel evidence that upregulation of AdipoRs in ECs potentiates the antiinflammatory effect of adiponectin; modulating adiponectin receptors may have potential therapeutic applications for cardiovascular complications associated with metabolic syndrome and diabetes.
|
18988888 |
2009 |
|
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
Serum adiponectin is associated with family history of diabetes independently of obesity and insulin resistance in healthy Korean men and women.
|
19088327 |
2009 |
|
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
Evaluation of the compound in vivo confirmed the reduced adiponectin response in animal models of obesity and diabetes while revealing strong beneficial effects on glucose, triglycerides, cholesterol, body weight, and other metabolic parameters.
|
19116277 |
2009 |
|
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
A novel heterozygous T deletion at position 186 in exon 2 of ADIPOQ, causing a frameshift at codon 62 and leading to a premature termination at codon 168 (p.Gly63ValfsX106), was found in two individuals with diabetes.
|
19178518 |
2009 |
|
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
Combined association of maternal and paternal family history of diabetes with plasma leptin and adiponectin in overweight Hispanic children.
|
19183309 |
2008 |
|
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Association between the adiponectin promoter rs266729 gene variant and oxidative stress in patients with diabetes mellitus.
|
19324915 |
2009 |
|
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Adiponectin SNP sites were investigated at +45 of exon 2 and at +276 of intron 2; these sites have been thought to be associated with diabetes or insulin resistance.
|
19484180 |
2009 |