|
LYMPHOPROLIFERATIVE SYNDROME 2
|
0.720 |
GeneticVariation
|
disease |
UNIPROT |
Combined immunodeficiency with life-threatening EBV-associated lymphoproliferative disorder in patients lacking functional CD27.
|
22801960 |
2013 |
|
LYMPHOPROLIFERATIVE SYNDROME 2
|
0.720 |
GeneticVariation
|
disease |
UNIPROT |
CD27 deficiency is associated with combined immunodeficiency and persistent symptomatic EBV viremia.
|
22197273 |
2012 |
|
Malignant Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We therefore generated a cytoplasmic deletion mutant of CD27 (CD27-trunc) to study the role of CD70 reverse signaling in the immunosurveillance of B-cell malignancies in vivo.
|
28495792 |
2017 |
|
leukemia
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
ETV6/RUNX1-like acute lymphoblastic leukemia: A novel B-cell precursor leukemia subtype associated with the CD27/CD44 immunophenotype.
|
28395118 |
2017 |
|
Childhood Leukemia
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
ETV6/RUNX1-like acute lymphoblastic leukemia: A novel B-cell precursor leukemia subtype associated with the CD27/CD44 immunophenotype.
|
28395118 |
2017 |
|
Acute lymphocytic leukemia
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
ETV6/RUNX1-like acute lymphoblastic leukemia: A novel B-cell precursor leukemia subtype associated with the CD27/CD44 immunophenotype.
|
28395118 |
2017 |
|
Epstein-Barr Virus Infections
|
0.040 |
GeneticVariation
|
group |
BEFREE |
We have analyzed EBV infection in nine cases of X-linked hyper-immunoglobulin M (hyper-IgM) syndrome who, due to a mutation in CD40 ligand gene, do not have a classical, class-switched memory B-cell population (IgD(-) CD27(+)).
|
16103163 |
2005 |
|
Waldenstrom Macroglobulinemia
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Among WM and IgM-MGUS, MYD88 L265P mutation was associated with some differences in clinical and biological characteristics, although usually minor; wild-type MYD88 cases had smaller M-component (1.77 vs 2.72 g/dl, P=0.022), more lymphocytosis (24 vs 5%, P=0.006), higher lactate dehydrogenase level (371 vs 265 UI/L, P=0.002), atypical immunophenotype (CD23-CD27+ +FMC7+ +), less Immunoglobulin Heavy Chain Variable gene (IGHV) somatic hypermutation (57 vs 97%, P=0.012) and less IGHV3-23 gene selection (9 vs 27%, P=0.014).
|
23446312 |
2013 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
ETV6/RUNX1-like acute lymphoblastic leukemia: A novel B-cell precursor leukemia subtype associated with the CD27/CD44 immunophenotype.
|
28395118 |
2017 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Further phenotyping of these subsets revealed that the blunting was most evident in CD8+ EMRA that expressed adhesion (CD11b: T1D 37.70%, Control 91.48%) and activation markers (CD69: T1D 29.87%, Control 161.43%), and appeared to be the most differentiated (CD27-CD28-: T1D 7.12%, Control 113.76%).
|
30753130 |
2019 |
|
Malaria
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Many chronic infections, including malaria and HIV, are associated with a large expansion of CD21-CD27- 'atypical' memory B cells (MBCs) that exhibit reduced B cell receptor (BCR) signaling and effector functions.
|
28953967 |
2017 |
|
Arthritis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
PB, SF and ST of 14 autoantibody (AB)-positive (rheumatoid factor [RF]-IgM, RF-IgA, anti-citrullinated peptide [CCP]), 13 negative RA and 13 no-RA chronic arthritides were examined for B-cell subsets (Bm1-Bm5 and IgD-CD27 classifications), zeta-associated protein kinase-70 (ZAP70) expression on B cells and cytokine levels (interleukin [IL]-1β, tumor necrosis factor [TNF]-α, IL-6, IL-8 and monocyte chemotactic protein [MCP]-1).
|
21607290 |
2012 |
|
Malignant neoplasm of breast
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In haplotype analysis, CCGAG haplotype in CD27 and TAA haplotype in CD70 conferred an increased risk of breast cancer (P = 5.60 × 10(-3); P = 7.75 × 10(-5), respectively), but TGC, TAC and TGA haplotypes in CD70 were associated with a decreased risk of breast cancer (P = 0.01; P = 5.2 × 10(-3); P = 2.00 × 10(-3), respectively).
|
22399187 |
2012 |
|
Lymphocytosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Among WM and IgM-MGUS, MYD88 L265P mutation was associated with some differences in clinical and biological characteristics, although usually minor; wild-type MYD88 cases had smaller M-component (1.77 vs 2.72 g/dl, P=0.022), more lymphocytosis (24 vs 5%, P=0.006), higher lactate dehydrogenase level (371 vs 265 UI/L, P=0.002), atypical immunophenotype (CD23-CD27+ +FMC7+ +), less Immunoglobulin Heavy Chain Variable gene (IGHV) somatic hypermutation (57 vs 97%, P=0.012) and less IGHV3-23 gene selection (9 vs 27%, P=0.014).
|
23446312 |
2013 |
|
Breast Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In haplotype analysis, CCGAG haplotype in CD27 and TAA haplotype in CD70 conferred an increased risk of breast cancer (P = 5.60 × 10(-3); P = 7.75 × 10(-5), respectively), but TGC, TAC and TGA haplotypes in CD70 were associated with a decreased risk of breast cancer (P = 0.01; P = 5.2 × 10(-3); P = 2.00 × 10(-3), respectively).
|
22399187 |
2012 |
|
Sporadic Breast Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Association of CD27 and CD70 gene polymorphisms with risk of sporadic breast cancer in Chinese women in Heilongjiang Province.
|
22399187 |
2012 |
|
LYMPHOPROLIFERATIVE SYNDROME 2
|
0.720 |
Biomarker
|
disease |
BEFREE |
We sought to identify novel mutations in TNFRSF7/CD27 and to provide an overview of clinical, immunologic, and laboratory phenotypes in patients with CD27 deficiency.
|
25843314 |
2015 |
|
LYMPHOPROLIFERATIVE SYNDROME 2
|
0.720 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
LYMPHOPROLIFERATIVE SYNDROME 2
|
0.720 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
We sought to identify novel mutations in TNFRSF7/CD27 and to provide an overview of clinical, immunologic, and laboratory phenotypes in patients with CD27 deficiency.
|
25843314 |
2015 |
|
LYMPHOPROLIFERATIVE SYNDROME 2
|
0.720 |
Biomarker
|
disease |
BEFREE |
CD27 is a co-stimulatory molecule of T cells, and inherited CD27 deficiency is characterized by high susceptibility to EBV infection, though the underlying pathological mechanisms have not yet been identified.
|
28011863 |
2017 |
|
Combined immunodeficiency
|
0.310 |
Biomarker
|
disease |
BEFREE |
Since homozygosity mapping and exome sequencing did not reveal additional modifying factors, our findings suggest that lack of functional CD27 predisposes towards a combined immunodeficiency associated with potentially fatal EBV-driven hemo-phagocytosis, lymphoproliferation, and lymphoma development.
|
22801960 |
2013 |
|
Combined immunodeficiency
|
0.310 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Novel mutations in TNFRSF7/CD27: Clinical, immunologic, and genetic characterization of human CD27 deficiency.
|
25843314 |
2015 |
|
Cachexia
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Molecular analysis of xenograft models of human cancer cachexia--possibilities for therapeutic intervention.
|
17878525 |
2007 |
|
Alcoholic Liver Diseases
|
0.200 |
Biomarker
|
group |
RGD |
Effect of tea polyphenol on cytokine gene expression in rats with alcoholic liver disease.
|
16698589 |
2006 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Finally, we review key literature describing progress in elucidating the efficacy and mode of action of OX40- and CD27-targeting mAbs in preclinical models and provide an overview of current clinical trials targeting these promising receptor/ligand pairings in cancer.
|
29118006 |
2018 |