|
Active tuberculosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
the study of CD27 expression using different approaches, whether it involves evaluation of CD45RA expression or not, is a robust biomarker for discriminating TB stages.
|
26253021 |
2015 |
|
Acute lymphocytic leukemia
|
0.040 |
Biomarker
|
disease |
BEFREE |
Modulation of the CD70/CD27 pathway may thus represent a novel therapeutic approach for augmenting magnitude and quality of the antileukemic response in B cell precursor acute lymphoblastic leukemia.
|
19109206 |
2009 |
|
Acute lymphocytic leukemia
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
ETV6/RUNX1-like acute lymphoblastic leukemia: A novel B-cell precursor leukemia subtype associated with the CD27/CD44 immunophenotype.
|
28395118 |
2017 |
|
Acute lymphocytic leukemia
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
CD44 and CD27 expression pattern in B cell precursor acute lymphoblastic leukemia and its clinical significance.
|
23263849 |
2013 |
|
Acute lymphocytic leukemia
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
The expression of CD27 and CD44 correlate with the genotype of B-precursor acute lymphoblastic leukemia (ALL).
|
18005092 |
2008 |
|
Acute myocardial infarction
|
0.010 |
Biomarker
|
disease |
BEFREE |
Although signaling through the CD27-CD70 co-stimulatory pathway are known to be important in CD4<sup>+</sup> T cell activation and proliferation in certain contexts, the role of the CD27-CD70 pathway in AMI remains unclear.
|
30527529 |
2019 |
|
Adult Acute Lymphocytic Leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The expression of CD27 and CD44 correlate with the genotype of B-precursor acute lymphoblastic leukemia (ALL).
|
18005092 |
2008 |
|
Adult Diffuse Large B-Cell Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Follicular lymphoma and diffuse large B cell lymphoma were also immunoreactive for CD148 and CD27 with some variation and discordance in expression.
|
12685844 |
2002 |
|
Adult Hodgkin Lymphoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Interestingly, the T cell transcription factor GATA-3 that is aberrantly expressed in HL was induced in most GC-LCLs and the memory B cell marker CD27 was activated in N-LCLs.
|
18430472 |
2008 |
|
Adult Hodgkin Lymphoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Flow cytometric analysis revealed that a large proportion of T cells expanded from patients with HL were CD62L(high) and CD27(high), and CCR7(low), consistent with early to mid effector T cells.
|
16982932 |
2006 |
|
Adult Lymphoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
On one hand, the defective expansion of EBV-specific CD8 T cells results from mutations in genes involved in T-cell activation (such as RASGRP1, MAGT1, and ITK), DNA metabolism (CTPS1) or co-stimulatory pathways (CD70, CD27, and TNFSFR9 (also known as CD137/4-1BB)) leads to impaired elimination of proliferating EBV-infected B cells and the occurrence of lymphoma.
|
31402499 |
2019 |
|
Adult Lymphoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
Finally, we show that a clinically relevant anti-human CD27 mAb, varlilumab, similarly synergizes with PD-L1 blockade for protection against lymphoma in human-CD27 transgenic mice.<b>Conclusions:</b> Our findings suggest that suboptimal T-cell invigoration in cancer patients undergoing treatment with PD-1 checkpoint blockers will be improved by dual PD-1 blockade and CD27 agonism and provide mechanistic insight into how these approaches cooperate for CD8<sup>+</sup> T-cell activation.<i></i>.
|
29514845 |
2018 |
|
Adult Lymphoma
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
The improved immune control by activated NK cells prolonged survival of CD27-trunc-expressing lymphoma-bearing mice.
|
28495792 |
2017 |
|
Adult Lymphoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
Development of a human monoclonal antibody for potential therapy of CD27-expressing lymphoma and leukemia.
|
22589397 |
2012 |
|
Adult Lymphoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
Blockade of CD27-CD70 or CD28-CD80/86 interactions by anti-CD70 or anti-CD80/86 antibodies restored LPS-mediated induction of IL-17 expression in CD4(+) T cells cocultured with lymphoma B cells.
|
19509224 |
2009 |
|
Adult Lymphoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
Functional CD70-CD27 interactions could contribute to lymphoma and leukemia progression.
|
16272354 |
2005 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
These data demonstrate the important role of the CD70/CD27 axis in immune responses in HTLV-1 carriers and ATL patients.
|
26077361 |
2016 |
|
Advanced lung cancer
|
0.010 |
Biomarker
|
disease |
BEFREE |
High Serum Soluble CD27 Level Correlates with Poor Performance Status and Reduced Survival in Patients with Advanced Lung Cancer.
|
31533124 |
2019 |
|
Alcoholic Liver Diseases
|
0.200 |
Biomarker
|
group |
RGD |
Effect of tea polyphenol on cytokine gene expression in rats with alcoholic liver disease.
|
16698589 |
2006 |
|
Allergic asthma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our results suggest that CD27 costimulation is dispensable for a Th2 cell mediated allergic asthma response and respiratory tolerance induction in murine models.
|
20600327 |
2010 |
|
Anaplastic thyroid carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
These data suggest that targeted immunotherapy for CD70/CD27 and PD-L1/PD-1 might be promising in anaplastic thyroid cancer.
|
28383817 |
2017 |
|
Aplastic Anemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Elevated proportion of CD27 in T cells may contribute to distinct immune pathogenesis for different severities of AA.
|
30953940 |
2019 |
|
Arteriosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, the role of CD27 in atherosclerosis remains unexplored.
|
29045618 |
2017 |
|
Arthritis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
PB, SF and ST of 14 autoantibody (AB)-positive (rheumatoid factor [RF]-IgM, RF-IgA, anti-citrullinated peptide [CCP]), 13 negative RA and 13 no-RA chronic arthritides were examined for B-cell subsets (Bm1-Bm5 and IgD-CD27 classifications), zeta-associated protein kinase-70 (ZAP70) expression on B cells and cytokine levels (interleukin [IL]-1β, tumor necrosis factor [TNF]-α, IL-6, IL-8 and monocyte chemotactic protein [MCP]-1).
|
21607290 |
2012 |
|
Arthritis, Psoriatic
|
0.010 |
Biomarker
|
disease |
BEFREE |
CD19(+)CD27(+)CD24(high) and CD19(+)CD24(high)CD38(high) Breg cells were decreased in PsA and Ps.
|
28461105 |
2017 |