|
IGA Glomerulonephritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The potential relationship between variants was analyzed.<b>Results</b>: In comparison with the HC, the frequency of CD3-CD19+ CD27+ IgD+IgM+ non-switched memory B cells (<i>P</i> = .0038) and CD3-CD19+ CD27hiCD38hi plasmablasts (<i>P</i> = .0467) and serum IL-6 (<i>P</i> = .0392) levels significantly increased in IgAN patients.
|
31670996 |
2020 |
|
Kidney Failure, Chronic
|
0.010 |
Biomarker
|
disease |
BEFREE |
Healthy volunteers and patients with ESRD had fewer unswitched memory (UM) B-cells (IgM + IgD + CD38<sup>low</sup>CD27+), and increased isotype switched memory (ISM) B-cells (IgM-IgD-CD38<sup>low</sup>CD27+).
|
31626945 |
2020 |
|
Degenerative polyarthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
CD3-CD19+IgD-IgM-CD27+CD38+ B cells were decreased in OA (p ≤ 0.001).
|
31624962 |
2020 |
|
Malignant Pleural Mesothelioma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Collectively, these findings suggest that the CD70-CD27 pathway enhances the malignant phenotypes of MPM and diminishes anti-tumor immune response in patients with these neoplasms.
|
31639216 |
2020 |
|
Chronic kidney disease stage 5
|
0.010 |
Biomarker
|
disease |
BEFREE |
Healthy volunteers and patients with ESRD had fewer unswitched memory (UM) B-cells (IgM + IgD + CD38<sup>low</sup>CD27+), and increased isotype switched memory (ISM) B-cells (IgM-IgD-CD38<sup>low</sup>CD27+).
|
31626945 |
2020 |
|
X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our analysis revealed that the abundance of 2 populations of naive B cells (CD20+CD27-CD22+IgM+HLA-DR+CXCR5+CXCR4++CD10+CD38+ and CD20+CD27-CD22+IgM+HLA-DR+CXCR5+CXCR4+CD10-CD38-) could differentially classify XMEN, ALPS, and healthy individuals.
|
31714901 |
2020 |
|
Aplastic Anemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Elevated proportion of CD27 in T cells may contribute to distinct immune pathogenesis for different severities of AA.
|
30953940 |
2019 |
|
Colorectal Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
CD70-CD27 pathway-modulating therapies may be applied to CRC patients regardless of their tumor MMR status.
|
30980190 |
2019 |
|
Dermatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Expression of CD27 on Ag-specific Teff cells resulted in enhanced skin inflammation when compared with CD27-deficient Teff cells.
|
31209102 |
2019 |
|
Fatigue
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
J Strength Cond Res 33(7S): S152-S158, 2019-This study was designed to investigate the impact of load (higher vs. lower) performed until or close to volitional fatigue on muscle strength (MS) and fat and bone-free lean mass (FBFM) in young women.
|
30640303 |
2019 |
|
Myocardial Infarction
|
0.010 |
Biomarker
|
disease |
BEFREE |
The role of CD27-CD70 signaling in myocardial infarction and cardiac remodeling.
|
30527529 |
2019 |
|
Periodontitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Memory B cells (CD27+CD38-) decreased their percentage in periodontitis.
|
30346027 |
2019 |
|
Acute myocardial infarction
|
0.010 |
Biomarker
|
disease |
BEFREE |
Although signaling through the CD27-CD70 co-stimulatory pathway are known to be important in CD4<sup>+</sup> T cell activation and proliferation in certain contexts, the role of the CD27-CD70 pathway in AMI remains unclear.
|
30527529 |
2019 |
|
Overweight and obesity
|
0.010 |
Biomarker
|
disease |
BEFREE |
We found fewer percentages of CD19+CD27+CD38High cells in the adipose tissue samples from individuals with overweight and obesity compared to individuals with normal-weight.
|
30115554 |
2019 |
|
Inflammatory dermatosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Expression of CD27 on Ag-specific Teff cells resulted in enhanced skin inflammation when compared with CD27-deficient Teff cells.
|
31209102 |
2019 |
|
Advanced lung cancer
|
0.010 |
Biomarker
|
disease |
BEFREE |
High Serum Soluble CD27 Level Correlates with Poor Performance Status and Reduced Survival in Patients with Advanced Lung Cancer.
|
31533124 |
2019 |
|
Septicemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
PD-L2 expression on CD27+ B cells was also higher in patients with sepsis (p = 0.0317).
|
29661225 |
2018 |
|
Hidradenitis Suppurativa
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Last, we found that CD27 expression was inversely correlated with T<sub>reg</sub> IL-17 production in skin of patients with psoriasis and hidradenitis suppurativa.
|
30578350 |
2018 |
|
Sepsis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
PD-L2 expression on CD27+ B cells was also higher in patients with sepsis (p = 0.0317).
|
29661225 |
2018 |
|
Skin carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Findings from this large epidemiologic study highlight the diversity of human Treg cell subpopulations associated with UVR, thus raising questions about the specific coordinated expression of CD45RA, CD27, CCR4, and cutaneous lymphocyte-associated Ag on Treg cells and the possibility that UVR contributes to nonmelanoma skin cancer carcinogenesis through Treg cell-mediated immune evasion.
|
30389774 |
2018 |
|
Sjogren's Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
The reactivity of antibodies expressed by CD19+CD10-CD27-IgM+CD21<sup>-/low</sup> cells isolated from the blood of patients with SS was tested using a polymerase chain reaction-based approach that allows us to clone and express, in vitro, recombinant antibodies produced by single B cells.
|
29073352 |
2018 |
|
Severe Sepsis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Higher frequency of CD28, CD27, OX40 on CD4+ T cells, OX40 on CD4+CD27-CD28- T cells and lower frequency of CD4+CD27-CD28- T cells in the SS group compared with the HC group and in the nonsurvived SS group compared with the survived SS subgroup were observed.
|
29028770 |
2018 |
|
Severe periodontitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
A significantly higher percentage of CD27+ memory B cells was observed in patients with SP.
|
29447240 |
2018 |
|
Arteriosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, the role of CD27 in atherosclerosis remains unexplored.
|
29045618 |
2017 |
|
Arthritis, Psoriatic
|
0.010 |
Biomarker
|
disease |
BEFREE |
CD19(+)CD27(+)CD24(high) and CD19(+)CD24(high)CD38(high) Breg cells were decreased in PsA and Ps.
|
28461105 |
2017 |